ID   RS18_DANRE              Reviewed;         152 AA.
AC   Q8JGS9; Q9IAC0;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=40S ribosomal protein S18;
GN   Name=rps18; Synonyms=ke3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   TISSUE=Embryo;
RX   PubMed=12006978; DOI=10.1038/ng896;
RA   Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W.,
RA   Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M.,
RA   Hopkins N.;
RT   "Insertional mutagenesis in zebrafish rapidly identifies genes essential
RT   for early vertebrate development.";
RL   Nat. Genet. 31:135-140(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 23-148.
RX   PubMed=11120825; DOI=10.4049/jimmunol.165.12.6984;
RA   Sueltmann H., Sato A., Murray B.W., Takezaki N., Geisler R., Rauch G.-J.,
RA   Klein J.;
RT   "Conservation of Mhc class III region synteny between zebrafish and human
RT   as determined by radiation hybrid mapping.";
RL   J. Immunol. 165:6984-6993(2000).
CC   -!- FUNCTION: Located at the top of the head of the 40S subunit, it
CC       contacts several helices of the 18S rRNA (By similarity). Plays an
CC       essential role in early embryonic development. {ECO:0000250,
CC       ECO:0000269|PubMed:12006978}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DISRUPTION PHENOTYPE: Embryos have a reduced forebrain, kinked tail and
CC       inflated hindbrain ventricle. {ECO:0000269|PubMed:12006978}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS13 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY099517; AAM28205.1; -; mRNA.
DR   EMBL; BC062289; AAH62289.1; -; mRNA.
DR   EMBL; AF210641; AAF70446.1; -; mRNA.
DR   RefSeq; NP_775341.1; NM_173234.1.
DR   AlphaFoldDB; Q8JGS9; -.
DR   SMR; Q8JGS9; -.
DR   STRING; 7955.ENSDARP00000005719; -.
DR   PaxDb; Q8JGS9; -.
DR   Ensembl; ENSDART00000167971; ENSDARP00000133054; ENSDARG00000100392.
DR   GeneID; 192300; -.
DR   KEGG; dre:192300; -.
DR   CTD; 6222; -.
DR   ZFIN; ZDB-GENE-020419-20; rps18.
DR   eggNOG; KOG3311; Eukaryota.
DR   GeneTree; ENSGT00390000012691; -.
DR   HOGENOM; CLU_103849_0_1_1; -.
DR   InParanoid; Q8JGS9; -.
DR   OMA; IRAYRGI; -.
DR   OrthoDB; 1343043at2759; -.
DR   PhylomeDB; Q8JGS9; -.
DR   TreeFam; TF317649; -.
DR   Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DRE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DRE-72649; Translation initiation complex formation.
DR   Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DRE-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-DRE-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DRE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q8JGS9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000100392; Expressed in spleen and 27 other tissues.
DR   ExpressionAtlas; Q8JGS9; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0015935; C:small ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0051726; P:regulation of cell cycle; IMP:ZFIN.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 4.10.910.10; -; 1.
DR   HAMAP; MF_01315; Ribosomal_S13_S18; 1.
DR   InterPro; IPR027437; 30s_Rbsml_prot_S13_C.
DR   InterPro; IPR001892; Ribosomal_S13.
DR   InterPro; IPR010979; Ribosomal_S13-like_H2TH.
DR   InterPro; IPR018269; Ribosomal_S13_CS.
DR   Pfam; PF00416; Ribosomal_S13; 1.
DR   PIRSF; PIRSF002134; Ribosomal_S13; 1.
DR   SUPFAM; SSF46946; SSF46946; 1.
DR   PROSITE; PS00646; RIBOSOMAL_S13_1; 1.
DR   PROSITE; PS50159; RIBOSOMAL_S13_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding.
FT   CHAIN           1..152
FT                   /note="40S ribosomal protein S18"
FT                   /id="PRO_0000132216"
SQ   SEQUENCE   152 AA;  17732 MW;  9D82B9E67E7D63B0 CRC64;
     MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLNKRAGELT
     EDEVERVVTI MQNPRQYKIP DWFLNRQKDI KDGKYSQVLA NGLDNKLRED LERLKKIRAH
     RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK KK