B3A3_RABIT
ID B3A3_RABIT Reviewed; 1233 AA.
AC O18917;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Anion exchange protein 3;
DE Short=AE 3;
DE Short=Anion exchanger 3;
DE AltName: Full=Anion exchanger 3 brain isoform;
DE AltName: Full=Neuronal band 3-like protein;
DE AltName: Full=Solute carrier family 4 member 3;
GN Name=SLC4A3; Synonyms=AE3;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RA Abuladze N., Pushkin A., Kurtz I.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plasma membrane anion exchange protein.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Neuronal.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000305}.
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DR EMBL; AF031650; AAB86859.1; -; mRNA.
DR RefSeq; NP_001075499.1; NM_001082030.1.
DR AlphaFoldDB; O18917; -.
DR SMR; O18917; -.
DR STRING; 9986.ENSOCUP00000009785; -.
DR PRIDE; O18917; -.
DR GeneID; 100008675; -.
DR KEGG; ocu:100008675; -.
DR CTD; 6508; -.
DR eggNOG; KOG1172; Eukaryota.
DR InParanoid; O18917; -.
DR OrthoDB; 265068at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
DR Gene3D; 3.40.930.10; -; 1.
DR InterPro; IPR001717; Anion_exchange.
DR InterPro; IPR002979; Anion_exchange_3.
DR InterPro; IPR018241; Anion_exchange_CS.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; PTHR11453; 1.
DR PANTHER; PTHR11453:SF15; PTHR11453:SF15; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR00165; ANIONEXCHNGR.
DR PRINTS; PR01189; ANIONEXHNGR3.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; SSF55804; 1.
DR TIGRFAMs; TIGR00834; ae; 1.
DR PROSITE; PS00219; ANION_EXCHANGER_1; 1.
DR PROSITE; PS00220; ANION_EXCHANGER_2; 1.
PE 2: Evidence at transcript level;
KW Anion exchange; Antiport; Glycoprotein; Ion transport; Lipoprotein;
KW Membrane; Methylation; Palmitate; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1233
FT /note="Anion exchange protein 3"
FT /id="PRO_0000079221"
FT TOPO_DOM 1..709
FT /note="Cytoplasmic"
FT TRANSMEM 710..732
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 738..775
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 795..817
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 827..848
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 894..911
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 912..926
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 927..947
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 981..1003
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1029..1050
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1084..1129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1156..1192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..1233
FT /note="Membrane (anion exchange)"
FT COMPBIAS 9..23
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..90
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..113
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..152
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 168
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P16283"
FT MOD_RES 171
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P16283"
FT MOD_RES 176
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23348"
FT MOD_RES 199
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P16283"
FT MOD_RES 296
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P16283"
FT LIPID 1166
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 874
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1233 AA; 135760 MW; AE486423E9818583 CRC64;
MANGVIPPPG GASPLPQVRV PLEEPPLSPD TEEEDDDLGK TLAVSRFGDL ISKPPAWDPE
KPSRSFSERD FAFHRHISHH THHPLSARLP PPHKLRRLPP TFARHTRRKR KKEKTSAPPS
EGTPPIQEEG GAGAHEGEEE EEEEEEGESE TEAVEPPPSG SPQKAKFSIG SDEDDSPGLP
GKAAFTKPLP SVGPRSDKSP QRSVSSSSPR ARAPRVAGER SRPWSPSASY DLRERLCPGS
ALGNPGGPEQ QVPTDEAEAQ MLGSADLDDM KSHRLEDNPG VRRHLVKEPS RVQGGRGSRG
GLTPTLRRKK KKQQPDRRPH EVFVELNELM LDRSQEPHWR ETARWIKFEE DVEEETERWG
KPHVASLSFR SLLELRRTIA HGAALLDLEQ TTLPGIAHLV VETMIVSDQI RPEDRASVLR
TLLLKHCHPN DDKDCGSFPR NPSSSSVNSV LGNHHATPSH GPDGAVPTMA DDLGEPAPLW
PHDPDAKERP LHMPGGDGHR GKSLKLLEKI PEDAEATVVL VGCVPFLEQP AAAFVRLSEA
VLLESVLEVP VPVRFLFVML GPSHISTDYH ELGRSIATLM SDKLFHEAAY QADDRQDLLG
AISEFLDGSI VIPPSEVEGR DLLRSVAAFQ RELLRKRRER EQTKVEMTTR GGYLAPGKEL
ALELGGSDAA PEDDPLLRTG SVFGGLIRDV KRRYPHYPSD LRDALHSQCV AAVLFIYFAA
LSPAITFGGL LGEKTEGLMG VSELIVSTAV LGVLFSLLGA QPLLVVGFSG PLLVFEGAFF
KFCQAQDLEY LTGRVWVGLW LVVFVLALVG AEGTFLVRYI SPFTQEIFAF LISLIFIYET
FHKLYKVFTE HPLLPFYPRE GALEGAPEAR LELNGSAPPP TEGPPGPRNQ PNTALLSLIL
MLGTFLIAFF LRKFRNSRFL GGKARRIIGD FGIPISILLM VLVDYSITDT YTQKLTVPTG
LSVTSPHKRT WFIPPLGSAR PFPPWMMVAA AVPALLVLIL IFMETQITAL IVSQKARRLL
KGSGFHLDLL LIGSLGGLCG LFGLPWLTAA TVRSVTHVNA LTVMRTAIAP GDKPQIQEVR
EQRVTGVLIA SLVGLSIVMG AVLRRIPLAV LFGIFLYMGV TSLSGIQLSQ RLLLILMPAK
HHPEQPYVTK VKTWRMHLFT CIQLACIALL WVVKSTAASL AFPFLLLLTV PLRRCLLPRL
FQDRELQALD SEDAEPNFDE DGQDEYNELH MPV
