RS18_PIG
ID RS18_PIG Reviewed; 152 AA.
AC P62272; P25232;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=40S ribosomal protein S18;
GN Name=RPS18;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kimura M., Kawakami K., Suzuki H., Hamasima N.;
RT "Cloning of the pig homolog of bacterial ribosomal protein S13.";
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Located at the top of the head of the 40S subunit, it
CC contacts several helices of the 18S rRNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS13 family.
CC {ECO:0000305}.
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DR EMBL; AB000911; BAA19211.1; -; mRNA.
DR RefSeq; NP_999105.1; NM_213940.1.
DR PDB; 3J7P; EM; 3.50 A; SS=1-152.
DR PDB; 3J7R; EM; 3.90 A; SS=1-152.
DR PDBsum; 3J7P; -.
DR PDBsum; 3J7R; -.
DR AlphaFoldDB; P62272; -.
DR SMR; P62272; -.
DR STRING; 9823.ENSSSCP00000001631; -.
DR PaxDb; P62272; -.
DR PeptideAtlas; P62272; -.
DR PRIDE; P62272; -.
DR Ensembl; ENSSSCT00000001675; ENSSSCP00000001631; ENSSSCG00000001502.
DR Ensembl; ENSSSCT00000084331; ENSSSCP00000067461; ENSSSCG00000001502.
DR Ensembl; ENSSSCT00005045123; ENSSSCP00005027626; ENSSSCG00005028347.
DR Ensembl; ENSSSCT00005045156; ENSSSCP00005027655; ENSSSCG00005028347.
DR Ensembl; ENSSSCT00015043258; ENSSSCP00015017091; ENSSSCG00015032681.
DR Ensembl; ENSSSCT00015043437; ENSSSCP00015017154; ENSSSCG00015032681.
DR Ensembl; ENSSSCT00040102981; ENSSSCP00040046583; ENSSSCG00040074457.
DR Ensembl; ENSSSCT00040103012; ENSSSCP00040046605; ENSSSCG00040074457.
DR Ensembl; ENSSSCT00045014585; ENSSSCP00045010117; ENSSSCG00045008633.
DR Ensembl; ENSSSCT00045014624; ENSSSCP00045010145; ENSSSCG00045008633.
DR Ensembl; ENSSSCT00065064713; ENSSSCP00065028044; ENSSSCG00065047309.
DR Ensembl; ENSSSCT00065064721; ENSSSCP00065028047; ENSSSCG00065047309.
DR Ensembl; ENSSSCT00070017106; ENSSSCP00070014159; ENSSSCG00070008759.
DR Ensembl; ENSSSCT00070017115; ENSSSCP00070014166; ENSSSCG00070008759.
DR GeneID; 396980; -.
DR KEGG; ssc:396980; -.
DR CTD; 6222; -.
DR VGNC; VGNC:109573; RPS18.
DR eggNOG; KOG3311; Eukaryota.
DR GeneTree; ENSGT00390000012691; -.
DR HOGENOM; CLU_103849_0_1_1; -.
DR InParanoid; P62272; -.
DR OMA; IRAYRGI; -.
DR OrthoDB; 1343043at2759; -.
DR TreeFam; TF317649; -.
DR Reactome; R-SSC-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SSC-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SSC-72649; Translation initiation complex formation.
DR Reactome; R-SSC-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-SSC-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-SSC-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SSC-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000008227; Chromosome 7.
DR Proteomes; UP000314985; Chromosome 7.
DR Bgee; ENSSSCG00000001502; Expressed in hindlimb bud and 45 other tissues.
DR Genevisible; P62272; SS.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0015935; C:small ribosomal subunit; ISS:AgBase.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:Ensembl.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 4.10.910.10; -; 1.
DR HAMAP; MF_01315; Ribosomal_S13_S18; 1.
DR InterPro; IPR027437; 30s_Rbsml_prot_S13_C.
DR InterPro; IPR001892; Ribosomal_S13.
DR InterPro; IPR010979; Ribosomal_S13-like_H2TH.
DR InterPro; IPR018269; Ribosomal_S13_CS.
DR Pfam; PF00416; Ribosomal_S13; 1.
DR PIRSF; PIRSF002134; Ribosomal_S13; 1.
DR SUPFAM; SSF46946; SSF46946; 1.
DR PROSITE; PS00646; RIBOSOMAL_S13_1; 1.
DR PROSITE; PS50159; RIBOSOMAL_S13_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Isopeptide bond; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding;
KW Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CHAIN 2..152
FT /note="40S ribosomal protein S18"
FT /id="PRO_0000132214"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT MOD_RES 94
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT MOD_RES 106
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CROSSLNK 91
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CROSSLNK 94
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CROSSLNK 106
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
SQ SEQUENCE 152 AA; 17719 MW; 4DAF0662C3F37F22 CRC64;
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT
EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA NGLDNKLRED LERLKKIRAH
RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK KK
