RS18_RAT
ID RS18_RAT Reviewed; 152 AA.
AC P62271; A0JN05; P25232;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=40S ribosomal protein S18;
GN Name=Rps18;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=1872840; DOI=10.1016/0006-291x(91)91022-5;
RA Chan Y.-L., Paz V., Wool I.G.;
RT "The primary structure of rat ribosomal protein S18.";
RL Biochem. Biophys. Res. Commun. 178:1212-1218(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15060004; DOI=10.1101/gr.1987704;
RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT "The genomic sequence and comparative analysis of the rat major
RT histocompatibility complex.";
RL Genome Res. 14:631-639(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 2-23; 26-34; 40-75; 79-86; 95-113 AND 125-130, CLEAVAGE
RP OF INITIATOR METHIONINE, ACETYLATION AT SER-2, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Pheochromocytoma;
RA Bienvenut W.V., von Kriegsheim A.F., Kolch W.;
RL Submitted (AUG-2006) to UniProtKB.
CC -!- FUNCTION: Located at the top of the head of the 40S subunit, it
CC contacts several helices of the 18S rRNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS13 family.
CC {ECO:0000305}.
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DR EMBL; X57529; CAA40750.1; -; mRNA.
DR EMBL; BX883042; CAE83925.1; -; Genomic_DNA.
DR EMBL; BC126072; AAI26073.1; -; mRNA.
DR PIR; JH0419; R3RT18.
DR RefSeq; NP_998722.1; NM_213557.1.
DR RefSeq; XP_002724624.1; XM_002724578.5.
DR RefSeq; XP_002727879.1; XM_002727833.5.
DR AlphaFoldDB; P62271; -.
DR SMR; P62271; -.
DR BioGRID; 1199814; 1.
DR BioGRID; 254650; 4.
DR IntAct; P62271; 6.
DR STRING; 10116.ENSRNOP00000047371; -.
DR iPTMnet; P62271; -.
DR PhosphoSitePlus; P62271; -.
DR jPOST; P62271; -.
DR PaxDb; P62271; -.
DR PRIDE; P62271; -.
DR Ensembl; ENSRNOT00000046010; ENSRNOP00000047371; ENSRNOG00000033152.
DR GeneID; 100360679; -.
DR GeneID; 294282; -.
DR KEGG; rno:100360679; -.
DR KEGG; rno:294282; -.
DR UCSC; RGD:3595; rat.
DR CTD; 100360679; -.
DR CTD; 6222; -.
DR RGD; 3595; Rps18.
DR VEuPathDB; HostDB:ENSRNOG00000000471; -.
DR eggNOG; KOG3311; Eukaryota.
DR GeneTree; ENSGT00390000012691; -.
DR HOGENOM; CLU_103849_0_1_1; -.
DR InParanoid; P62271; -.
DR OMA; IRAYRGI; -.
DR OrthoDB; 1343043at2759; -.
DR PhylomeDB; P62271; -.
DR TreeFam; TF317649; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62271; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000028505; Expressed in thymus and 19 other tissues.
DR ExpressionAtlas; P62271; baseline.
DR Genevisible; P62271; RN.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0014069; C:postsynaptic density; ISO:RGD.
DR GO; GO:0015935; C:small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0019901; F:protein kinase binding; IPI:RGD.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0008499; F:UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; IEA:Ensembl.
DR GO; GO:0001574; P:ganglioside biosynthetic process; IEA:Ensembl.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 4.10.910.10; -; 1.
DR HAMAP; MF_01315; Ribosomal_S13_S18; 1.
DR InterPro; IPR027437; 30s_Rbsml_prot_S13_C.
DR InterPro; IPR001892; Ribosomal_S13.
DR InterPro; IPR010979; Ribosomal_S13-like_H2TH.
DR InterPro; IPR018269; Ribosomal_S13_CS.
DR Pfam; PF00416; Ribosomal_S13; 1.
DR PIRSF; PIRSF002134; Ribosomal_S13; 1.
DR SUPFAM; SSF46946; SSF46946; 1.
DR PROSITE; PS00646; RIBOSOMAL_S13_1; 1.
DR PROSITE; PS50159; RIBOSOMAL_S13_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Direct protein sequencing; Isopeptide bond;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW rRNA-binding; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.4"
FT CHAIN 2..152
FT /note="40S ribosomal protein S18"
FT /id="PRO_0000132215"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000269|Ref.4"
FT MOD_RES 94
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT MOD_RES 106
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CROSSLNK 91
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CROSSLNK 94
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
FT CROSSLNK 106
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62269"
SQ SEQUENCE 152 AA; 17719 MW; 4DAF0662C3F37F22 CRC64;
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT
EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA NGLDNKLRED LERLKKIRAH
RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK KK
