ID   143BA_DANRE             Reviewed;         244 AA.
AC   Q5PRD0; A3KNI9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=14-3-3 protein beta/alpha-A;
GN   Name=ywhaba; Synonyms=ywhab1; ORFNames=wu:fb80c08;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Testis;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein implicated in the regulation of a large
CC       spectrum of both general and specialized signaling pathways. Binds to a
CC       large number of partners, usually by recognition of a phosphoserine or
CC       phosphothreonine motif. Binding generally results in the modulation of
CC       the activity of the binding partner (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer, and heterodimer with other family members.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 14-3-3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH86710.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC086710; AAH86710.1; ALT_INIT; mRNA.
DR   EMBL; BC133863; AAI33864.1; -; mRNA.
DR   RefSeq; NP_001076267.1; NM_001082798.1.
DR   AlphaFoldDB; Q5PRD0; -.
DR   SMR; Q5PRD0; -.
DR   IntAct; Q5PRD0; 1.
DR   MINT; Q5PRD0; -.
DR   STRING; 7955.ENSDARP00000027118; -.
DR   PaxDb; Q5PRD0; -.
DR   PRIDE; Q5PRD0; -.
DR   Ensembl; ENSDART00000025940; ENSDARP00000027118; ENSDARG00000013078.
DR   GeneID; 323055; -.
DR   KEGG; dre:323055; -.
DR   CTD; 323055; -.
DR   ZFIN; ZDB-GENE-030131-6583; ywhaba.
DR   eggNOG; KOG0841; Eukaryota.
DR   GeneTree; ENSGT01050000244817; -.
DR   InParanoid; Q5PRD0; -.
DR   OrthoDB; 1176818at2759; -.
DR   PhylomeDB; Q5PRD0; -.
DR   TreeFam; TF102003; -.
DR   Reactome; R-DRE-111447; Activation of BAD and translocation to mitochondria.
DR   Reactome; R-DRE-165159; MTOR signalling.
DR   Reactome; R-DRE-166208; mTORC1-mediated signalling.
DR   Reactome; R-DRE-170968; Frs2-mediated activation.
DR   Reactome; R-DRE-2028269; Signaling by Hippo.
DR   Reactome; R-DRE-392517; Rap1 signalling.
DR   Reactome; R-DRE-450385; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
DR   Reactome; R-DRE-450513; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
DR   Reactome; R-DRE-5625740; RHO GTPases activate PKNs.
DR   Reactome; R-DRE-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-DRE-5673000; RAF activation.
DR   Reactome; R-DRE-5674135; MAP2K and MAPK activation.
DR   Reactome; R-DRE-5675221; Negative regulation of MAPK pathway.
DR   Reactome; R-DRE-75035; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
DR   Reactome; R-DRE-9614399; Regulation of localization of FOXO transcription factors.
DR   PRO; PR:Q5PRD0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000013078; Expressed in brain and 40 other tissues.
DR   ExpressionAtlas; Q5PRD0; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IMP:ZFIN.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 1.20.190.20; -; 1.
DR   InterPro; IPR000308; 14-3-3.
DR   InterPro; IPR023409; 14-3-3_CS.
DR   InterPro; IPR036815; 14-3-3_dom_sf.
DR   InterPro; IPR023410; 14-3-3_domain.
DR   PANTHER; PTHR18860; PTHR18860; 1.
DR   Pfam; PF00244; 14-3-3; 1.
DR   PIRSF; PIRSF000868; 14-3-3; 1.
DR   PRINTS; PR00305; 1433ZETA.
DR   SMART; SM00101; 14_3_3; 1.
DR   SUPFAM; SSF48445; SSF48445; 1.
DR   PROSITE; PS00796; 1433_1; 1.
DR   PROSITE; PS00797; 1433_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Reference proteome.
FT   CHAIN           1..244
FT                   /note="14-3-3 protein beta/alpha-A"
FT                   /id="PRO_0000058602"
FT   SITE            56
FT                   /note="Interaction with phosphoserine on interacting
FT                   protein"
FT                   /evidence="ECO:0000250"
FT   SITE            127
FT                   /note="Interaction with phosphoserine on interacting
FT                   protein"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   244 AA;  27647 MW;  D8421934B4BF17EA CRC64;
     MDKSDLVQKA KLAEQAERYD DMAASMKAVT EGGVELSNEE RNLLSVAYKN VVGARRSSWR
     VISSIEQKTE GNEKKQQMAR EYREKIEAEL QEICNDVLGL LEKYLIPNAS QAESKVFYLK
     MKGDYYRYLS EVASGDSKRT TVENSQKAYQ DAFEISKKEM QPTHPIRLGL ALNFSVFYYE
     ILNTPEQACS LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS ENQGDEGDAG
     EGEN