B3GL1_PIG
ID B3GL1_PIG Reviewed; 331 AA.
AC Q864U6;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1;
DE Short=Beta-1,3-GalNAc-T1;
DE EC=2.4.1.79 {ECO:0000250|UniProtKB:O75752};
DE AltName: Full=Beta-1,3-galactosyltransferase 3;
DE Short=Beta-1,3-GalTase 3;
DE Short=Beta3Gal-T3;
DE Short=Beta3GalT3;
DE Short=b3Gal-T3;
DE AltName: Full=Beta-3-Gx-T3;
DE AltName: Full=Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase;
DE AltName: Full=Globoside synthase;
DE AltName: Full=UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase;
GN Name=B3GALNT1; Synonyms=B3GALT3;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Small intestine;
RA Python P., Joerg H., Neuenschwander S., Stranzinger G., Voegeli P.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transfers N-acetylgalactosamine onto globotriaosylceramide.
CC Plays a critical role in preimplantation stage embryonic development.
CC {ECO:0000250|UniProtKB:O75752, ECO:0000250|UniProtKB:Q920V1}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-
CC galactosamine = globoside Gb4Cer (d18:1(4E)) + H(+) + UDP;
CC Xref=Rhea:RHEA:22252, ChEBI:CHEBI:15378, ChEBI:CHEBI:18259,
CC ChEBI:CHEBI:18313, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.79;
CC Evidence={ECO:0000250|UniProtKB:O75752};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22253;
CC Evidence={ECO:0000250|UniProtKB:O75752};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:O75752};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:O75752}; Single-pass type II membrane protein
CC {ECO:0000250|UniProtKB:O75752}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family.
CC {ECO:0000305}.
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DR EMBL; AY253340; AAO92025.1; -; mRNA.
DR RefSeq; NP_999516.1; NM_214351.1.
DR RefSeq; XP_005652470.1; XM_005652413.2.
DR RefSeq; XP_013848528.1; XM_013993074.1.
DR AlphaFoldDB; Q864U6; -.
DR SMR; Q864U6; -.
DR STRING; 9823.ENSSSCP00000023800; -.
DR CAZy; GT31; Glycosyltransferase Family 31.
DR PaxDb; Q864U6; -.
DR PRIDE; Q864U6; -.
DR Ensembl; ENSSSCT00000026210; ENSSSCP00000023800; ENSSSCG00000021774.
DR Ensembl; ENSSSCT00000037923; ENSSSCP00000056792; ENSSSCG00000021774.
DR Ensembl; ENSSSCT00000046695; ENSSSCP00000035844; ENSSSCG00000021774.
DR Ensembl; ENSSSCT00000051857; ENSSSCP00000039248; ENSSSCG00000021774.
DR Ensembl; ENSSSCT00000061956; ENSSSCP00000055915; ENSSSCG00000021774.
DR Ensembl; ENSSSCT00000075553; ENSSSCP00000061281; ENSSSCG00000021774.
DR Ensembl; ENSSSCT00000077726; ENSSSCP00000065176; ENSSSCG00000021774.
DR Ensembl; ENSSSCT00000080716; ENSSSCP00000064709; ENSSSCG00000021774.
DR Ensembl; ENSSSCT00005044305; ENSSSCP00005027130; ENSSSCG00005027963.
DR Ensembl; ENSSSCT00005044321; ENSSSCP00005027139; ENSSSCG00005027963.
DR Ensembl; ENSSSCT00005044329; ENSSSCP00005027144; ENSSSCG00005027963.
DR Ensembl; ENSSSCT00005044335; ENSSSCP00005027148; ENSSSCG00005027963.
DR Ensembl; ENSSSCT00005044343; ENSSSCP00005027152; ENSSSCG00005027963.
DR Ensembl; ENSSSCT00005044348; ENSSSCP00005027154; ENSSSCG00005027963.
DR Ensembl; ENSSSCT00005044359; ENSSSCP00005027160; ENSSSCG00005027963.
DR Ensembl; ENSSSCT00005044368; ENSSSCP00005027167; ENSSSCG00005027963.
DR Ensembl; ENSSSCT00015079526; ENSSSCP00015032105; ENSSSCG00015059568.
DR Ensembl; ENSSSCT00015079573; ENSSSCP00015032135; ENSSSCG00015059568.
DR Ensembl; ENSSSCT00015079623; ENSSSCP00015032154; ENSSSCG00015059568.
DR Ensembl; ENSSSCT00015079684; ENSSSCP00015032186; ENSSSCG00015059568.
DR Ensembl; ENSSSCT00015079732; ENSSSCP00015032208; ENSSSCG00015059568.
DR Ensembl; ENSSSCT00015079781; ENSSSCP00015032228; ENSSSCG00015059568.
DR Ensembl; ENSSSCT00015079847; ENSSSCP00015032250; ENSSSCG00015059568.
DR Ensembl; ENSSSCT00015079898; ENSSSCP00015032272; ENSSSCG00015059568.
DR Ensembl; ENSSSCT00040085150; ENSSSCP00040037212; ENSSSCG00040062493.
DR Ensembl; ENSSSCT00040085196; ENSSSCP00040037239; ENSSSCG00040062493.
DR Ensembl; ENSSSCT00040085249; ENSSSCP00040037268; ENSSSCG00040062493.
DR Ensembl; ENSSSCT00040085297; ENSSSCP00040037295; ENSSSCG00040062493.
DR Ensembl; ENSSSCT00040085360; ENSSSCP00040037331; ENSSSCG00040062493.
DR Ensembl; ENSSSCT00040085439; ENSSSCP00040037371; ENSSSCG00040062493.
DR Ensembl; ENSSSCT00040085494; ENSSSCP00040037405; ENSSSCG00040062493.
DR Ensembl; ENSSSCT00040085535; ENSSSCP00040037427; ENSSSCG00040062493.
DR Ensembl; ENSSSCT00045007033; ENSSSCP00045004822; ENSSSCG00045004222.
DR Ensembl; ENSSSCT00045007035; ENSSSCP00045004824; ENSSSCG00045004222.
DR Ensembl; ENSSSCT00045007036; ENSSSCP00045004825; ENSSSCG00045004222.
DR Ensembl; ENSSSCT00045007038; ENSSSCP00045004827; ENSSSCG00045004222.
DR Ensembl; ENSSSCT00045007041; ENSSSCP00045004830; ENSSSCG00045004222.
DR Ensembl; ENSSSCT00045007044; ENSSSCP00045004832; ENSSSCG00045004222.
DR Ensembl; ENSSSCT00045007046; ENSSSCP00045004834; ENSSSCG00045004222.
DR Ensembl; ENSSSCT00045007052; ENSSSCP00045004837; ENSSSCG00045004222.
DR Ensembl; ENSSSCT00065068420; ENSSSCP00065029788; ENSSSCG00065049965.
DR Ensembl; ENSSSCT00065068424; ENSSSCP00065029791; ENSSSCG00065049965.
DR Ensembl; ENSSSCT00065068427; ENSSSCP00065029794; ENSSSCG00065049965.
DR Ensembl; ENSSSCT00065068428; ENSSSCP00065029795; ENSSSCG00065049965.
DR Ensembl; ENSSSCT00065068430; ENSSSCP00065029796; ENSSSCG00065049965.
DR Ensembl; ENSSSCT00065068433; ENSSSCP00065029797; ENSSSCG00065049965.
DR Ensembl; ENSSSCT00065068439; ENSSSCP00065029801; ENSSSCG00065049965.
DR Ensembl; ENSSSCT00065068444; ENSSSCP00065029802; ENSSSCG00065049965.
DR Ensembl; ENSSSCT00070048129; ENSSSCP00070040624; ENSSSCG00070024100.
DR Ensembl; ENSSSCT00070048130; ENSSSCP00070040625; ENSSSCG00070024100.
DR Ensembl; ENSSSCT00070048134; ENSSSCP00070040629; ENSSSCG00070024100.
DR GeneID; 397634; -.
DR KEGG; ssc:397634; -.
DR CTD; 8706; -.
DR VGNC; VGNC:108632; B3GALNT1.
DR eggNOG; KOG2287; Eukaryota.
DR GeneTree; ENSGT00940000162252; -.
DR HOGENOM; CLU_036849_2_4_1; -.
DR InParanoid; Q864U6; -.
DR OMA; PYCSGMG; -.
DR OrthoDB; 1037602at2759; -.
DR TreeFam; TF318639; -.
DR Reactome; R-SSC-1660662; Glycosphingolipid metabolism.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Proteomes; UP000314985; Chromosome 13.
DR Bgee; ENSSSCG00000021774; Expressed in Ammon's horn and 45 other tissues.
DR ExpressionAtlas; Q864U6; baseline and differential.
DR Genevisible; Q864U6; SS.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0047273; F:galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016757; F:glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0008499; F:UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; IBA:GO_Central.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0009312; P:oligosaccharide biosynthetic process; IEA:Ensembl.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR InterPro; IPR002659; Glyco_trans_31.
DR PANTHER; PTHR11214; PTHR11214; 1.
DR Pfam; PF01762; Galactosyl_T; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Glycosyltransferase; Golgi apparatus; Lipid metabolism;
KW Magnesium; Membrane; Reference proteome; Signal-anchor; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..331
FT /note="UDP-GalNAc:beta-1,3-N-
FT acetylgalactosaminyltransferase 1"
FT /id="PRO_0000219156"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..43
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..331
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 326
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 331 AA; 39437 MW; 3686FB95DA581CE3 CRC64;
MAPALPITLP SKMSLRSLKW SLLLLSLLSF LVMWYLSLPH YNVIERVNWM YFYEYEPIYR
QDFHFTLREH SNCSHQNPFL VILVTSHPAD VKARQAIRVT WGEKKSWWGY EVLTFFLLGQ
QAEREDKVLA LSLEDEHLLY GDIIRQDFLD TYNNLTLKTI MAFRWVTEFC PNARYIMKTD
TDVFINTGNL VKYLLNLNHS EKFFTGYPLI DNYSYRGFYQ KTHISYQEYP FKVFPPYCSG
LGYIMSRDLV PRIYEMMSHV KPIKFEDVYV GICLNLLKVD IHIPEDTNLF FLYRIHLDVC
QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y
