B3GN9_HUMAN
ID B3GN9_HUMAN Reviewed; 402 AA.
AC Q6UX72; Q96EK0;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 {ECO:0000312|HGNC:HGNC:28714};
DE Short=BGnT-9 {ECO:0000312|HGNC:HGNC:28714};
DE Short=Beta-1,3-Gn-T9;
DE Short=Beta-1,3-N-acetylglucosaminyltransferase 9;
DE Short=Beta3Gn-T9 {ECO:0000312|HGNC:HGNC:28714};
DE EC=2.4.1.-;
GN Name=B3GNT9 {ECO:0000312|HGNC:HGNC:28714}; ORFNames=UNQ1922/PRO4397;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAQ88849.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2] {ECO:0000312|EMBL:EAW83079.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000255}; Single-
CC pass type II membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family.
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC012191; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY358485; AAQ88849.1; -; mRNA.
DR EMBL; CH471092; EAW83079.1; -; Genomic_DNA.
DR EMBL; BC012191; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS45509.1; -.
DR RefSeq; NP_171608.2; NM_033309.2.
DR AlphaFoldDB; Q6UX72; -.
DR SMR; Q6UX72; -.
DR BioGRID; 124240; 2.
DR IntAct; Q6UX72; 2.
DR STRING; 9606.ENSP00000400157; -.
DR CAZy; GT31; Glycosyltransferase Family 31.
DR GlyGen; Q6UX72; 3 sites, 1 O-linked glycan (3 sites).
DR iPTMnet; Q6UX72; -.
DR PhosphoSitePlus; Q6UX72; -.
DR BioMuta; B3GNT9; -.
DR DMDM; 74738184; -.
DR jPOST; Q6UX72; -.
DR MassIVE; Q6UX72; -.
DR PaxDb; Q6UX72; -.
DR PeptideAtlas; Q6UX72; -.
DR PRIDE; Q6UX72; -.
DR ProteomicsDB; 67574; -.
DR TopDownProteomics; Q6UX72; -.
DR Antibodypedia; 65852; 9 antibodies from 5 providers.
DR DNASU; 84752; -.
DR Ensembl; ENST00000449549.4; ENSP00000400157.3; ENSG00000237172.4.
DR GeneID; 84752; -.
DR KEGG; hsa:84752; -.
DR MANE-Select; ENST00000449549.4; ENSP00000400157.3; NM_033309.3; NP_171608.2.
DR UCSC; uc002erf.4; human.
DR CTD; 84752; -.
DR DisGeNET; 84752; -.
DR GeneCards; B3GNT9; -.
DR HGNC; HGNC:28714; B3GNT9.
DR HPA; ENSG00000237172; Low tissue specificity.
DR neXtProt; NX_Q6UX72; -.
DR OpenTargets; ENSG00000237172; -.
DR PharmGKB; PA164716431; -.
DR VEuPathDB; HostDB:ENSG00000237172; -.
DR eggNOG; KOG2287; Eukaryota.
DR GeneTree; ENSGT00940000162243; -.
DR HOGENOM; CLU_036849_5_2_1; -.
DR InParanoid; Q6UX72; -.
DR OMA; VAEIWLM; -.
DR OrthoDB; 1037602at2759; -.
DR PhylomeDB; Q6UX72; -.
DR TreeFam; TF318639; -.
DR PathwayCommons; Q6UX72; -.
DR Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR SignaLink; Q6UX72; -.
DR BioGRID-ORCS; 84752; 12 hits in 1064 CRISPR screens.
DR ChiTaRS; B3GNT9; human.
DR GenomeRNAi; 84752; -.
DR Pharos; Q6UX72; Tdark.
DR PRO; PR:Q6UX72; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6UX72; protein.
DR Bgee; ENSG00000237172; Expressed in stromal cell of endometrium and 165 other tissues.
DR Genevisible; Q6UX72; HS.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0030311; P:poly-N-acetyllactosamine biosynthetic process; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR InterPro; IPR002659; Glyco_trans_31.
DR PANTHER; PTHR11214; PTHR11214; 1.
DR Pfam; PF01762; Galactosyl_T; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase; Golgi apparatus; Membrane; Reference proteome;
KW Signal-anchor; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..402
FT /note="UDP-GlcNAc:betaGal beta-1,3-N-
FT acetylglucosaminyltransferase 9"
FT /id="PRO_0000352762"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..27
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..402
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 32..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 402 AA; 43751 MW; E4FFEBDFD5F8F2FB CRC64;
MRRRLRLRRD ALLTLLLGAS LGLLLYAQRD GAAPTASAPR GRGRAAPRPT PGPRAFQLPD
AGAAPPAYEG DTPAPPTPTG PFDFARYLRA KDQRRFPLLI NQPHKCRGDG APGGRPDLLI
AVKSVAEDFE RRQAVRQTWG AEGRVQGALV RRVFLLGVPR GAGSGGADEV GEGARTHWRA
LLRAESLAYA DILLWAFDDT FFNLTLKEIH FLAWASAFCP DVRFVFKGDA DVFVNVGNLL
EFLAPRDPAQ DLLAGDVIVH ARPIRTRASK YYIPEAVYGL PAYPAYAGGG GFVLSGATLH
RLAGACAQVE LFPIDDVFLG MCLQRLRLTP EPHPAFRTFG IPQPSAAPHL STFDPCFYRE
LVVVHGLSAA DIWLMWRLLH GPHGPACAHP QPVAAGPFQW DS
