RS19_ECOLI
ID RS19_ECOLI Reviewed; 92 AA.
AC P0A7U3; P02375; Q2M6Y1;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=30S ribosomal protein S19;
DE AltName: Full=Small ribosomal subunit protein uS19 {ECO:0000303|PubMed:24524803};
GN Name=rpsS; OrderedLocusNames=b3316, JW3278;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3892488; DOI=10.1093/nar/13.12.4521;
RA Zurawski G., Zurawski S.M.;
RT "Structure of the Escherichia coli S10 ribosomal protein operon.";
RL Nucleic Acids Res. 13:4521-4526(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP PROTEIN SEQUENCE OF 2-92, AND SUBUNIT.
RC STRAIN=K;
RX PubMed=348496; DOI=10.1016/0014-5793(78)80180-x;
RA Yaguchi M., Wittmann H.G.;
RT "Primary structure of protein S19 from the small ribosomal subunit of
RT Escherichia coli.";
RL FEBS Lett. 88:227-230(1978).
RN [5]
RP PROTEIN SEQUENCE OF 66-70, SUBUNIT, AND CROSS-LINKING TO S13.
RC STRAIN=K12 / A19;
RX PubMed=3279034; DOI=10.1016/s0021-9258(18)68924-0;
RA Pohl T., Wittmann-Liebold B.;
RT "Identification of a cross-link in the Escherichia coli ribosomal protein
RT pair S13-S19 at the amino acid level.";
RL J. Biol. Chem. 263:4293-4301(1988).
RN [6]
RP CROSS-LINKING TO THE TRNA CENTRAL FOLD.
RC STRAIN=MRE-600;
RX PubMed=8524654; DOI=10.1093/nar/23.22.4635;
RA Osswald M., Doering T., Brimacombe R.;
RT "The ribosomal neighbourhood of the central fold of tRNA: cross-links from
RT position 47 of tRNA located at the A, P or E site.";
RL Nucleic Acids Res. 23:4635-4641(1995).
RN [7]
RP NOMENCLATURE.
RX PubMed=24524803; DOI=10.1016/j.sbi.2014.01.002;
RA Ban N., Beckmann R., Cate J.H.D., Dinman J.D., Dragon F., Ellis S.R.,
RA Lafontaine D.L.J., Lindahl L., Liljas A., Lipton J.M., McAlear M.A.,
RA Moore P.B., Noller H.F., Ortega J., Panse V.G., Ramakrishnan V.,
RA Spahn C.M.T., Steitz T.A., Tchorzewski M., Tollervey D., Warren A.J.,
RA Williamson J.R., Wilson D., Yonath A., Yusupov M.;
RT "A new system for naming ribosomal proteins.";
RL Curr. Opin. Struct. Biol. 24:165-169(2014).
RN [8]
RP ABILITY OF VARIANT MW145 TO SUPPRESS A RIMM DELETION.
RC STRAIN=MW100;
RX PubMed=15496525; DOI=10.1261/rna.7720204;
RA Loevgren J.M., Bylund G.O., Srivastava M.K., Lundberg L.A.C., Persson O.P.,
RA Wingsle G., Wikstroem P.M.;
RT "The PRC-barrel domain of the ribosome maturation protein RimM mediates
RT binding to ribosomal protein S19 in the 30S ribosomal subunits.";
RL RNA 10:1798-1812(2004).
RN [9]
RP MASS SPECTROMETRY, AND SUBUNIT.
RC STRAIN=K12 / ATCC 25404 / DSM 5698 / NCIMB 11290;
RX PubMed=10094780; DOI=10.1006/abio.1998.3077;
RA Arnold R.J., Reilly J.P.;
RT "Observation of Escherichia coli ribosomal proteins and their
RT posttranslational modifications by mass spectrometry.";
RL Anal. Biochem. 269:105-112(1999).
RN [10]
RP 3D-STRUCTURE MODELING, AND SUBUNIT.
RX PubMed=12244297; DOI=10.1038/nsb841;
RA Tung C.-S., Joseph S., Sanbonmatsu K.Y.;
RT "All-atom homology model of the Escherichia coli 30S ribosomal subunit.";
RL Nat. Struct. Biol. 9:750-755(2002).
RN [11]
RP STRUCTURE BY ELECTRON MICROSCOPY (11.50 ANGSTROMS), SUBUNIT, AND
RP INTERSUBUNIT BRIDGE FORMATION.
RC STRAIN=MRE-600;
RX PubMed=12809609; DOI=10.1016/s0092-8674(03)00427-6;
RA Gao H., Sengupta J., Valle M., Korostelev A., Eswar N., Stagg S.M.,
RA Van Roey P., Agrawal R.K., Harvey S.C., Sali A., Chapman M.S., Frank J.;
RT "Study of the structural dynamics of the E. coli 70S ribosome using real-
RT space refinement.";
RL Cell 113:789-801(2003).
RN [12]
RP 3D-STRUCTURE MODELING OF RIBOSOMAL COMPLEXES INCLUDING BRIDGE CHANGES UPON
RP TRANSLOCATION, AND SUBUNIT.
RX PubMed=12859903; DOI=10.1016/s0092-8674(03)00476-8;
RA Valle M., Zavialov A., Sengupta J., Rawat U., Ehrenberg M., Frank J.;
RT "Locking and unlocking of ribosomal motions.";
RL Cell 114:123-134(2003).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (3.46 ANGSTROMS) OF 2 DIFFERENT RIBOSOME STRUCTURES
RP INCLUDING THE INTERSUBUNIT BRIDGE B1B, AND SUBUNIT.
RC STRAIN=MRE-600;
RX PubMed=16272117; DOI=10.1126/science.1117230;
RA Schuwirth B.S., Borovinskaya M.A., Hau C.W., Zhang W., Vila-Sanjurjo A.,
RA Holton J.M., Cate J.H.D.;
RT "Structures of the bacterial ribosome at 3.5 A resolution.";
RL Science 310:827-834(2005).
RN [14]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.0 ANGSTROMS) OF 70S RIBOSOME IN COMPLEX
RP WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=27906160; DOI=10.1038/nature20822;
RA Ma C., Kurita D., Li N., Chen Y., Himeno H., Gao N.;
RT "Mechanistic insights into the alternative translation termination by ArfA
RT and RF2.";
RL Nature 541:550-553(2017).
RN [15]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.1 ANGSTROMS) OF 70S RIBOSOME IN COMPLEX
RP WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=27906161; DOI=10.1038/nature20821;
RA Huter P., Mueller C., Beckert B., Arenz S., Berninghausen O., Beckmann R.,
RA Wilson D.N.;
RT "Structural basis for ArfA-RF2-mediated translation termination on mRNAs
RT lacking stop codons.";
RL Nature 541:546-549(2017).
RN [16]
RP STRUCTURE BY ELECTRON MICROSCOPY (2.97 ANGSTROMS) OF 70S RIBOSOME IN
RP COMPLEX WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=27934701; DOI=10.1126/science.aai9127;
RA James N.R., Brown A., Gordiyenko Y., Ramakrishnan V.;
RT "Translational termination without a stop codon.";
RL Science 354:1437-1440(2016).
RN [17]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.52 ANGSTROMS) OF 70S RIBOSOME IN
RP COMPLEX WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=28077875; DOI=10.1038/nature21053;
RA Zeng F., Chen Y., Remis J., Shekhar M., Phillips J.C., Tajkhorshid E.,
RA Jin H.;
RT "Structural basis of co-translational quality control by ArfA and RF2 bound
RT to ribosome.";
RL Nature 541:554-557(2017).
CC -!- FUNCTION: In the E.coli 70S ribosome in the initiation state
CC (PubMed:12809609) it has been modeled to contact the 23S rRNA of the
CC 50S subunit forming part of bridge B1a; this bridge is broken in the
CC model with bound EF-G. The 23S rRNA contact site in bridge B1a is
CC modeled to differ in different ribosomal states (PubMed:12859903),
CC contacting alternately S13 or S19. In the 3.5 angstroms resolved
CC ribosome structures (PubMed:16272117) the contacts between L5, S13 and
CC S19 bridge B1b are different, confirming the dynamic nature of this
CC interaction. Bridge B1a is not visible in the crystallized ribosomes
CC due to 23S rRNA disorder. {ECO:0000269|PubMed:12809609,
CC ECO:0000269|PubMed:12859903, ECO:0000269|PubMed:16272117}.
CC -!- FUNCTION: Protein S19 forms a complex with S13 that binds strongly to
CC the 16S ribosomal RNA. Contacts the A site tRNA.
CC -!- SUBUNIT: Part of the 30S ribosomal subunit (PubMed:348496,
CC PubMed:3279034, PubMed:10094780, PubMed:12244297, PubMed:12809609,
CC PubMed:12859903, PubMed:16272117, PubMed:27934701, PubMed:27906160,
CC PubMed:27906161). Binds S13 and L5 and cross-links to the A site tRNA
CC (PubMed:12809609, PubMed:16272117, PubMed:12859903).
CC {ECO:0000269|PubMed:10094780, ECO:0000269|PubMed:12244297,
CC ECO:0000269|PubMed:12809609, ECO:0000269|PubMed:12859903,
CC ECO:0000269|PubMed:16272117, ECO:0000269|PubMed:27906160,
CC ECO:0000269|PubMed:27906161, ECO:0000269|PubMed:27934701,
CC ECO:0000269|PubMed:3279034, ECO:0000269|PubMed:348496}.
CC -!- MASS SPECTROMETRY: Mass=10299.6; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10094780};
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS19 family.
CC {ECO:0000305}.
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DR EMBL; X02613; CAA26464.1; -; Genomic_DNA.
DR EMBL; U18997; AAA58113.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76341.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77975.1; -; Genomic_DNA.
DR PIR; F23129; R3EC19.
DR RefSeq; NP_417775.1; NC_000913.3.
DR RefSeq; WP_001138117.1; NZ_STEB01000038.1.
DR PDB; 2YKR; EM; 9.80 A; S=3-81.
DR PDB; 3J9Y; EM; 3.90 A; s=1-92.
DR PDB; 3J9Z; EM; 3.60 A; SS=2-92.
DR PDB; 3JA1; EM; 3.60 A; SS=2-92.
DR PDB; 3JBU; EM; 3.64 A; S=1-92.
DR PDB; 3JBV; EM; 3.32 A; S=1-92.
DR PDB; 3JCD; EM; 3.70 A; s=1-92.
DR PDB; 3JCE; EM; 3.20 A; s=1-92.
DR PDB; 3JCJ; EM; 3.70 A; z=1-92.
DR PDB; 3JCN; EM; 4.60 A; t=1-92.
DR PDB; 4A2I; EM; 16.50 A; S=3-81.
DR PDB; 4ADV; EM; 13.50 A; S=2-92.
DR PDB; 4U1U; X-ray; 2.95 A; AS/CS=3-81.
DR PDB; 4U1V; X-ray; 3.00 A; AS/CS=3-81.
DR PDB; 4U20; X-ray; 2.90 A; AS/CS=3-81.
DR PDB; 4U24; X-ray; 2.90 A; AS/CS=3-81.
DR PDB; 4U25; X-ray; 2.90 A; AS/CS=3-81.
DR PDB; 4U26; X-ray; 2.80 A; AS/CS=3-81.
DR PDB; 4U27; X-ray; 2.80 A; AS/CS=3-81.
DR PDB; 4V47; EM; 12.30 A; BS=2-92.
DR PDB; 4V48; EM; 11.50 A; BS=2-92.
DR PDB; 4V4H; X-ray; 3.46 A; AS/CS=1-92.
DR PDB; 4V4Q; X-ray; 3.46 A; AS/CS=2-92.
DR PDB; 4V4V; EM; 15.00 A; AS=2-88.
DR PDB; 4V4W; EM; 15.00 A; AS=2-88.
DR PDB; 4V50; X-ray; 3.22 A; AS/CS=2-92.
DR PDB; 4V52; X-ray; 3.21 A; AS/CS=2-92.
DR PDB; 4V53; X-ray; 3.54 A; AS/CS=2-92.
DR PDB; 4V54; X-ray; 3.30 A; AS/CS=2-92.
DR PDB; 4V55; X-ray; 4.00 A; AS/CS=2-92.
DR PDB; 4V56; X-ray; 3.93 A; AS/CS=2-92.
DR PDB; 4V57; X-ray; 3.50 A; AS/CS=2-92.
DR PDB; 4V5B; X-ray; 3.74 A; BS/DS=2-92.
DR PDB; 4V5H; EM; 5.80 A; AS=3-81.
DR PDB; 4V5Y; X-ray; 4.45 A; AS/CS=2-92.
DR PDB; 4V64; X-ray; 3.50 A; AS/CS=2-92.
DR PDB; 4V65; EM; 9.00 A; AL=1-92.
DR PDB; 4V66; EM; 9.00 A; AL=1-92.
DR PDB; 4V69; EM; 6.70 A; AS=3-81.
DR PDB; 4V6C; X-ray; 3.19 A; AS/CS=1-92.
DR PDB; 4V6D; X-ray; 3.81 A; AS/CS=1-92.
DR PDB; 4V6E; X-ray; 3.71 A; AS/CS=1-92.
DR PDB; 4V6K; EM; 8.25 A; BW=1-92.
DR PDB; 4V6L; EM; 13.20 A; AW=1-92.
DR PDB; 4V6M; EM; 7.10 A; AS=2-92.
DR PDB; 4V6N; EM; 12.10 A; BV=2-92.
DR PDB; 4V6O; EM; 14.70 A; AV=2-92.
DR PDB; 4V6P; EM; 13.50 A; AV=2-92.
DR PDB; 4V6Q; EM; 11.50 A; AV=2-92.
DR PDB; 4V6R; EM; 11.50 A; AV=2-92.
DR PDB; 4V6S; EM; 13.10 A; BU=2-92.
DR PDB; 4V6T; EM; 8.30 A; AS=3-81.
DR PDB; 4V6V; EM; 9.80 A; AS=2-92.
DR PDB; 4V6Y; EM; 12.00 A; AS=3-81.
DR PDB; 4V6Z; EM; 12.00 A; AS=3-81.
DR PDB; 4V70; EM; 17.00 A; AS=3-81.
DR PDB; 4V71; EM; 20.00 A; AS=3-81.
DR PDB; 4V72; EM; 13.00 A; AS=3-81.
DR PDB; 4V73; EM; 15.00 A; AS=3-81.
DR PDB; 4V74; EM; 17.00 A; AS=3-81.
DR PDB; 4V75; EM; 12.00 A; AS=3-81.
DR PDB; 4V76; EM; 17.00 A; AS=3-81.
DR PDB; 4V77; EM; 17.00 A; AS=3-81.
DR PDB; 4V78; EM; 20.00 A; AS=3-81.
DR PDB; 4V79; EM; 15.00 A; AS=3-81.
DR PDB; 4V7A; EM; 9.00 A; AS=3-81.
DR PDB; 4V7B; EM; 6.80 A; AS=1-92.
DR PDB; 4V7C; EM; 7.60 A; AS=2-92.
DR PDB; 4V7D; EM; 7.60 A; BS=2-92.
DR PDB; 4V7I; EM; 9.60 A; BS=1-92.
DR PDB; 4V7S; X-ray; 3.25 A; AS/CS=3-81.
DR PDB; 4V7T; X-ray; 3.19 A; AS/CS=3-81.
DR PDB; 4V7U; X-ray; 3.10 A; AS/CS=3-81.
DR PDB; 4V7V; X-ray; 3.29 A; AS/CS=3-81.
DR PDB; 4V85; X-ray; 3.20 A; AS=1-92.
DR PDB; 4V89; X-ray; 3.70 A; AS=1-92.
DR PDB; 4V9C; X-ray; 3.30 A; AS/CS=1-92.
DR PDB; 4V9D; X-ray; 3.00 A; AS/BS=3-81.
DR PDB; 4V9O; X-ray; 2.90 A; BS/DS/FS/HS=1-92.
DR PDB; 4V9P; X-ray; 2.90 A; BS/DS/FS/HS=1-92.
DR PDB; 4WF1; X-ray; 3.09 A; AS/CS=3-81.
DR PDB; 4WOI; X-ray; 3.00 A; AS/DS=1-92.
DR PDB; 4WWW; X-ray; 3.10 A; QS/XS=3-81.
DR PDB; 4YBB; X-ray; 2.10 A; AS/BS=3-81.
DR PDB; 5AFI; EM; 2.90 A; s=1-92.
DR PDB; 5H5U; EM; 3.00 A; z=2-92.
DR PDB; 5IQR; EM; 3.00 A; x=1-92.
DR PDB; 5IT8; X-ray; 3.12 A; AS/BS=3-81.
DR PDB; 5J5B; X-ray; 2.80 A; AS/BS=3-81.
DR PDB; 5J7L; X-ray; 3.00 A; AS/BS=3-81.
DR PDB; 5J88; X-ray; 3.32 A; AS/BS=3-81.
DR PDB; 5J8A; X-ray; 3.10 A; AS/BS=3-81.
DR PDB; 5J91; X-ray; 2.96 A; AS/BS=3-81.
DR PDB; 5JC9; X-ray; 3.03 A; AS/BS=3-81.
DR PDB; 5JTE; EM; 3.60 A; AS=1-92.
DR PDB; 5JU8; EM; 3.60 A; AS=1-92.
DR PDB; 5KCR; EM; 3.60 A; 1s=1-92.
DR PDB; 5KCS; EM; 3.90 A; 1s=1-92.
DR PDB; 5KPS; EM; 3.90 A; 24=1-92.
DR PDB; 5KPV; EM; 4.10 A; 23=1-92.
DR PDB; 5KPW; EM; 3.90 A; 23=1-92.
DR PDB; 5KPX; EM; 3.90 A; 23=1-92.
DR PDB; 5L3P; EM; 3.70 A; s=1-92.
DR PDB; 5LZA; EM; 3.60 A; s=3-81.
DR PDB; 5LZB; EM; 5.30 A; s=3-81.
DR PDB; 5LZC; EM; 4.80 A; s=3-81.
DR PDB; 5LZD; EM; 3.40 A; s=3-88.
DR PDB; 5LZE; EM; 3.50 A; s=3-81.
DR PDB; 5LZF; EM; 4.60 A; s=3-88.
DR PDB; 5MDV; EM; 2.97 A; x=1-92.
DR PDB; 5MDW; EM; 3.06 A; x=1-92.
DR PDB; 5MDY; EM; 3.35 A; x=1-92.
DR PDB; 5MDZ; EM; 3.10 A; x=1-92.
DR PDB; 5ME0; EM; 13.50 A; S=1-92.
DR PDB; 5ME1; EM; 13.50 A; S=1-92.
DR PDB; 5MGP; EM; 3.10 A; s=3-81.
DR PDB; 5MY1; EM; 7.60 A; S=2-92.
DR PDB; 5NO2; EM; 5.16 A; S=3-81.
DR PDB; 5NO3; EM; 5.16 A; S=3-81.
DR PDB; 5NO4; EM; 5.16 A; S=3-81.
DR PDB; 5NP6; EM; 3.60 A; V=3-81.
DR PDB; 5NWY; EM; 2.93 A; I=1-92.
DR PDB; 5O2R; EM; 3.40 A; s=3-81.
DR PDB; 5U4I; EM; 3.50 A; s=2-83.
DR PDB; 5U9F; EM; 3.20 A; S=1-92.
DR PDB; 5U9G; EM; 3.20 A; S=1-92.
DR PDB; 5UYK; EM; 3.90 A; S=3-81.
DR PDB; 5UYL; EM; 3.60 A; S=3-81.
DR PDB; 5UYM; EM; 3.20 A; S=3-81.
DR PDB; 5UYN; EM; 4.00 A; S=3-81.
DR PDB; 5UYP; EM; 3.90 A; S=3-81.
DR PDB; 5UYQ; EM; 3.80 A; S=3-81.
DR PDB; 5UZ4; EM; 5.80 A; S=1-92.
DR PDB; 5WDT; EM; 3.00 A; s=3-81.
DR PDB; 5WE4; EM; 3.10 A; s=3-81.
DR PDB; 5WE6; EM; 3.40 A; s=3-81.
DR PDB; 5WFK; EM; 3.40 A; s=3-81.
DR PDB; 6BU8; EM; 3.50 A; S=3-81.
DR PDB; 6BY1; X-ray; 3.94 A; AS/BS=3-81.
DR PDB; 6ENF; EM; 3.20 A; s=3-81.
DR PDB; 6ENJ; EM; 3.70 A; s=3-81.
DR PDB; 6ENU; EM; 3.10 A; s=3-81.
DR PDB; 6GWT; EM; 3.80 A; s=3-81.
DR PDB; 6GXM; EM; 3.80 A; s=3-81.
DR PDB; 6GXN; EM; 3.90 A; s=3-81.
DR PDB; 6GXO; EM; 3.90 A; s=3-81.
DR PDB; 6GXP; EM; 4.40 A; s=3-81.
DR PDB; 6H4N; EM; 3.00 A; s=3-81.
DR PDB; 6H58; EM; 7.90 A; s/ss=3-81.
DR PDB; 6HRM; EM; 2.96 A; x=2-84.
DR PDB; 6I7V; X-ray; 2.90 A; AS/BS=3-81.
DR PDB; 6O9J; EM; 3.90 A; s=3-81.
DR PDB; 6O9K; EM; 4.00 A; s=3-81.
DR PDB; 6OFX; EM; 3.30 A; X=3-81.
DR PDB; 6OG7; EM; 3.30 A; X=3-81.
DR PDB; 6ORE; EM; 2.90 A; x=2-84.
DR PDB; 6ORL; EM; 3.50 A; x=2-84.
DR PDB; 6OST; EM; 4.20 A; x=2-84.
DR PDB; 6OT3; EM; 3.90 A; x=2-84.
DR PDB; 6OUO; EM; 3.70 A; x=2-84.
DR PDB; 6Q98; EM; 4.30 A; x=1-92.
DR PDB; 6Q9A; EM; 3.70 A; x=2-84.
DR PDB; 6SZS; EM; 3.06 A; s=1-92.
DR PDB; 6TBV; EM; 2.70 A; S191=1-92.
DR PDB; 6TC3; EM; 2.70 A; S191=1-92.
DR PDB; 6VWL; EM; 3.10 A; r=1-92.
DR PDB; 6VWM; EM; 3.40 A; r=1-92.
DR PDB; 6VWN; EM; 3.40 A; r=1-92.
DR PDB; 6W6K; EM; 3.60 A; S=1-92.
DR PDB; 6W77; EM; 3.60 A; S=1-92.
DR PDB; 6W7M; EM; 3.80 A; S=1-92.
DR PDB; 6W7N; EM; 3.40 A; S=1-92.
DR PDB; 6WD6; EM; 3.70 A; X=3-81.
DR PDB; 6WDB; EM; 4.00 A; X=3-81.
DR PDB; 6WDC; EM; 4.20 A; X=3-81.
DR PDB; 6WDD; EM; 3.20 A; X=3-81.
DR PDB; 6WDE; EM; 3.00 A; X=3-81.
DR PDB; 6WDF; EM; 3.30 A; X=3-81.
DR PDB; 6WDG; EM; 3.30 A; X=3-81.
DR PDB; 6WDH; EM; 4.30 A; X=3-81.
DR PDB; 6WDI; EM; 4.00 A; X=3-81.
DR PDB; 6WDJ; EM; 3.70 A; X=3-81.
DR PDB; 6WDK; EM; 3.60 A; X=3-81.
DR PDB; 6WDL; EM; 3.70 A; X=3-81.
DR PDB; 6WDM; EM; 3.60 A; X=3-81.
DR PDB; 6WNV; EM; 3.50 A; X=3-81.
DR PDB; 6WNW; EM; 3.20 A; X=3-81.
DR PDB; 6XE0; EM; 6.80 A; S=3-81.
DR PDB; 6XZA; EM; 2.66 A; S1=3-81.
DR PDB; 6XZB; EM; 2.54 A; S1=3-81.
DR PDB; 6Y69; EM; 2.86 A; s=3-81.
DR PDB; 6ZTL; EM; 3.50 A; AS=1-92.
DR PDB; 7ABZ; EM; 3.21 A; x=3-81.
DR PDB; 7AC7; EM; 3.08 A; x=2-83.
DR PDB; 7ACJ; EM; 3.20 A; x=2-87.
DR PDB; 7ACR; EM; 3.44 A; x=2-84.
DR PDB; 7AF3; EM; 2.82 A; S=1-92.
DR PDB; 7AF5; EM; 2.96 A; S=1-92.
DR PDB; 7AF8; EM; 2.75 A; S=1-92.
DR PDB; 7AFA; EM; 2.95 A; S=1-92.
DR PDB; 7AFD; EM; 3.44 A; S=1-92.
DR PDB; 7AFH; EM; 3.59 A; S=1-92.
DR PDB; 7AFK; EM; 4.90 A; S=1-92.
DR PDB; 7AFN; EM; 3.86 A; S=1-92.
DR PDB; 7B5K; EM; 2.90 A; s=3-84.
DR PDB; 7BOE; EM; 2.90 A; S=1-92.
DR PDB; 7BOH; EM; 2.82 A; S=1-92.
DR PDB; 7D6Z; EM; 3.40 A; z=1-92.
DR PDB; 7D80; EM; 4.10 A; T=1-92.
DR PDB; 7JSS; EM; 3.70 A; X=3-81.
DR PDB; 7JSW; EM; 3.80 A; X=3-81.
DR PDB; 7JSZ; EM; 3.70 A; X=3-81.
DR PDB; 7JT1; EM; 3.30 A; X=3-81.
DR PDB; 7JT2; EM; 3.50 A; X=3-81.
DR PDB; 7JT3; EM; 3.70 A; X=3-81.
DR PDB; 7K50; EM; 3.40 A; X=3-81.
DR PDB; 7K51; EM; 3.50 A; X=3-81.
DR PDB; 7K52; EM; 3.40 A; X=3-81.
DR PDB; 7K53; EM; 3.20 A; X=3-81.
DR PDB; 7K54; EM; 3.20 A; X=3-81.
DR PDB; 7K55; EM; 3.30 A; X=3-81.
DR PDB; 7LV0; EM; 3.20 A; X=3-81.
DR PDB; 7N1P; EM; 2.33 A; SS=1-92.
DR PDB; 7N2C; EM; 2.72 A; SS=1-92.
DR PDB; 7N2U; EM; 2.53 A; SS=1-92.
DR PDB; 7N2V; EM; 2.54 A; SS=1-92.
DR PDB; 7N30; EM; 2.66 A; SS=1-92.
DR PDB; 7N31; EM; 2.69 A; SS=1-92.
DR PDB; 7NAR; EM; 3.00 A; S=1-92.
DR PDB; 7NAT; EM; 3.59 A; S=1-92.
DR PDB; 7NAU; EM; 3.78 A; S=1-92.
DR PDB; 7NAV; EM; 4.80 A; S=1-92.
DR PDB; 7NBU; EM; 3.11 A; S=2-85.
DR PDB; 7O19; EM; 2.90 A; AS=1-92.
DR PDB; 7O1A; EM; 2.40 A; AS=1-92.
DR PDB; 7O1C; EM; 2.60 A; AS=1-92.
DR PDB; 7OE0; EM; 2.69 A; S=2-92.
DR PDB; 7OE1; EM; 3.05 A; S=2-92.
DR PDB; 7OIZ; EM; 2.90 A; S=1-92.
DR PDB; 7OJ0; EM; 3.50 A; S=1-92.
DR PDB; 7P3K; EM; 2.90 A; S=1-92.
DR PDB; 7PJV; EM; 3.10 A; s=1-92.
DR PDB; 7PJY; EM; 3.10 A; s=1-92.
DR PDB; 7QG8; EM; 3.97 A; t=1-92.
DR PDB; 7SS9; EM; 3.90 A; X=3-81.
DR PDB; 7SSD; EM; 3.30 A; X=3-81.
DR PDB; 7SSL; EM; 3.80 A; X=3-81.
DR PDB; 7SSN; EM; 3.20 A; X=3-81.
DR PDB; 7SSO; EM; 3.20 A; X=3-81.
DR PDB; 7SSW; EM; 3.80 A; X=3-81.
DR PDB; 7ST2; EM; 2.90 A; X=3-81.
DR PDB; 7ST6; EM; 3.00 A; X=3-81.
DR PDB; 7ST7; EM; 3.20 A; X=3-81.
DR PDBsum; 2YKR; -.
DR PDBsum; 3J9Y; -.
DR PDBsum; 3J9Z; -.
DR PDBsum; 3JA1; -.
DR PDBsum; 3JBU; -.
DR PDBsum; 3JBV; -.
DR PDBsum; 3JCD; -.
DR PDBsum; 3JCE; -.
DR PDBsum; 3JCJ; -.
DR PDBsum; 3JCN; -.
DR PDBsum; 4A2I; -.
DR PDBsum; 4ADV; -.
DR PDBsum; 4U1U; -.
DR PDBsum; 4U1V; -.
DR PDBsum; 4U20; -.
DR PDBsum; 4U24; -.
DR PDBsum; 4U25; -.
DR PDBsum; 4U26; -.
DR PDBsum; 4U27; -.
DR PDBsum; 4V47; -.
DR PDBsum; 4V48; -.
DR PDBsum; 4V4H; -.
DR PDBsum; 4V4Q; -.
DR PDBsum; 4V4V; -.
DR PDBsum; 4V4W; -.
DR PDBsum; 4V50; -.
DR PDBsum; 4V52; -.
DR PDBsum; 4V53; -.
DR PDBsum; 4V54; -.
DR PDBsum; 4V55; -.
DR PDBsum; 4V56; -.
DR PDBsum; 4V57; -.
DR PDBsum; 4V5B; -.
DR PDBsum; 4V5H; -.
DR PDBsum; 4V5Y; -.
DR PDBsum; 4V64; -.
DR PDBsum; 4V65; -.
DR PDBsum; 4V66; -.
DR PDBsum; 4V69; -.
DR PDBsum; 4V6C; -.
DR PDBsum; 4V6D; -.
DR PDBsum; 4V6E; -.
DR PDBsum; 4V6K; -.
DR PDBsum; 4V6L; -.
DR PDBsum; 4V6M; -.
DR PDBsum; 4V6N; -.
DR PDBsum; 4V6O; -.
DR PDBsum; 4V6P; -.
DR PDBsum; 4V6Q; -.
DR PDBsum; 4V6R; -.
DR PDBsum; 4V6S; -.
DR PDBsum; 4V6T; -.
DR PDBsum; 4V6V; -.
DR PDBsum; 4V6Y; -.
DR PDBsum; 4V6Z; -.
DR PDBsum; 4V70; -.
DR PDBsum; 4V71; -.
DR PDBsum; 4V72; -.
DR PDBsum; 4V73; -.
DR PDBsum; 4V74; -.
DR PDBsum; 4V75; -.
DR PDBsum; 4V76; -.
DR PDBsum; 4V77; -.
DR PDBsum; 4V78; -.
DR PDBsum; 4V79; -.
DR PDBsum; 4V7A; -.
DR PDBsum; 4V7B; -.
DR PDBsum; 4V7C; -.
DR PDBsum; 4V7D; -.
DR PDBsum; 4V7I; -.
DR PDBsum; 4V7S; -.
DR PDBsum; 4V7T; -.
DR PDBsum; 4V7U; -.
DR PDBsum; 4V7V; -.
DR PDBsum; 4V85; -.
DR PDBsum; 4V89; -.
DR PDBsum; 4V9C; -.
DR PDBsum; 4V9D; -.
DR PDBsum; 4V9O; -.
DR PDBsum; 4V9P; -.
DR PDBsum; 4WF1; -.
DR PDBsum; 4WOI; -.
DR PDBsum; 4WWW; -.
DR PDBsum; 4YBB; -.
DR PDBsum; 5AFI; -.
DR PDBsum; 5H5U; -.
DR PDBsum; 5IQR; -.
DR PDBsum; 5IT8; -.
DR PDBsum; 5J5B; -.
DR PDBsum; 5J7L; -.
DR PDBsum; 5J88; -.
DR PDBsum; 5J8A; -.
DR PDBsum; 5J91; -.
DR PDBsum; 5JC9; -.
DR PDBsum; 5JTE; -.
DR PDBsum; 5JU8; -.
DR PDBsum; 5KCR; -.
DR PDBsum; 5KCS; -.
DR PDBsum; 5KPS; -.
DR PDBsum; 5KPV; -.
DR PDBsum; 5KPW; -.
DR PDBsum; 5KPX; -.
DR PDBsum; 5L3P; -.
DR PDBsum; 5LZA; -.
DR PDBsum; 5LZB; -.
DR PDBsum; 5LZC; -.
DR PDBsum; 5LZD; -.
DR PDBsum; 5LZE; -.
DR PDBsum; 5LZF; -.
DR PDBsum; 5MDV; -.
DR PDBsum; 5MDW; -.
DR PDBsum; 5MDY; -.
DR PDBsum; 5MDZ; -.
DR PDBsum; 5ME0; -.
DR PDBsum; 5ME1; -.
DR PDBsum; 5MGP; -.
DR PDBsum; 5MY1; -.
DR PDBsum; 5NO2; -.
DR PDBsum; 5NO3; -.
DR PDBsum; 5NO4; -.
DR PDBsum; 5NP6; -.
DR PDBsum; 5NWY; -.
DR PDBsum; 5O2R; -.
DR PDBsum; 5U4I; -.
DR PDBsum; 5U9F; -.
DR PDBsum; 5U9G; -.
DR PDBsum; 5UYK; -.
DR PDBsum; 5UYL; -.
DR PDBsum; 5UYM; -.
DR PDBsum; 5UYN; -.
DR PDBsum; 5UYP; -.
DR PDBsum; 5UYQ; -.
DR PDBsum; 5UZ4; -.
DR PDBsum; 5WDT; -.
DR PDBsum; 5WE4; -.
DR PDBsum; 5WE6; -.
DR PDBsum; 5WFK; -.
DR PDBsum; 6BU8; -.
DR PDBsum; 6BY1; -.
DR PDBsum; 6ENF; -.
DR PDBsum; 6ENJ; -.
DR PDBsum; 6ENU; -.
DR PDBsum; 6GWT; -.
DR PDBsum; 6GXM; -.
DR PDBsum; 6GXN; -.
DR PDBsum; 6GXO; -.
DR PDBsum; 6GXP; -.
DR PDBsum; 6H4N; -.
DR PDBsum; 6H58; -.
DR PDBsum; 6HRM; -.
DR PDBsum; 6I7V; -.
DR PDBsum; 6O9J; -.
DR PDBsum; 6O9K; -.
DR PDBsum; 6OFX; -.
DR PDBsum; 6OG7; -.
DR PDBsum; 6ORE; -.
DR PDBsum; 6ORL; -.
DR PDBsum; 6OST; -.
DR PDBsum; 6OT3; -.
DR PDBsum; 6OUO; -.
DR PDBsum; 6Q98; -.
DR PDBsum; 6Q9A; -.
DR PDBsum; 6SZS; -.
DR PDBsum; 6TBV; -.
DR PDBsum; 6TC3; -.
DR PDBsum; 6VWL; -.
DR PDBsum; 6VWM; -.
DR PDBsum; 6VWN; -.
DR PDBsum; 6W6K; -.
DR PDBsum; 6W77; -.
DR PDBsum; 6W7M; -.
DR PDBsum; 6W7N; -.
DR PDBsum; 6WD6; -.
DR PDBsum; 6WDB; -.
DR PDBsum; 6WDC; -.
DR PDBsum; 6WDD; -.
DR PDBsum; 6WDE; -.
DR PDBsum; 6WDF; -.
DR PDBsum; 6WDG; -.
DR PDBsum; 6WDH; -.
DR PDBsum; 6WDI; -.
DR PDBsum; 6WDJ; -.
DR PDBsum; 6WDK; -.
DR PDBsum; 6WDL; -.
DR PDBsum; 6WDM; -.
DR PDBsum; 6WNV; -.
DR PDBsum; 6WNW; -.
DR PDBsum; 6XE0; -.
DR PDBsum; 6XZA; -.
DR PDBsum; 6XZB; -.
DR PDBsum; 6Y69; -.
DR PDBsum; 6ZTL; -.
DR PDBsum; 7ABZ; -.
DR PDBsum; 7AC7; -.
DR PDBsum; 7ACJ; -.
DR PDBsum; 7ACR; -.
DR PDBsum; 7AF3; -.
DR PDBsum; 7AF5; -.
DR PDBsum; 7AF8; -.
DR PDBsum; 7AFA; -.
DR PDBsum; 7AFD; -.
DR PDBsum; 7AFH; -.
DR PDBsum; 7AFK; -.
DR PDBsum; 7AFN; -.
DR PDBsum; 7B5K; -.
DR PDBsum; 7BOE; -.
DR PDBsum; 7BOH; -.
DR PDBsum; 7D6Z; -.
DR PDBsum; 7D80; -.
DR PDBsum; 7JSS; -.
DR PDBsum; 7JSW; -.
DR PDBsum; 7JSZ; -.
DR PDBsum; 7JT1; -.
DR PDBsum; 7JT2; -.
DR PDBsum; 7JT3; -.
DR PDBsum; 7K50; -.
DR PDBsum; 7K51; -.
DR PDBsum; 7K52; -.
DR PDBsum; 7K53; -.
DR PDBsum; 7K54; -.
DR PDBsum; 7K55; -.
DR PDBsum; 7LV0; -.
DR PDBsum; 7N1P; -.
DR PDBsum; 7N2C; -.
DR PDBsum; 7N2U; -.
DR PDBsum; 7N2V; -.
DR PDBsum; 7N30; -.
DR PDBsum; 7N31; -.
DR PDBsum; 7NAR; -.
DR PDBsum; 7NAT; -.
DR PDBsum; 7NAU; -.
DR PDBsum; 7NAV; -.
DR PDBsum; 7NBU; -.
DR PDBsum; 7O19; -.
DR PDBsum; 7O1A; -.
DR PDBsum; 7O1C; -.
DR PDBsum; 7OE0; -.
DR PDBsum; 7OE1; -.
DR PDBsum; 7OIZ; -.
DR PDBsum; 7OJ0; -.
DR PDBsum; 7P3K; -.
DR PDBsum; 7PJV; -.
DR PDBsum; 7PJY; -.
DR PDBsum; 7QG8; -.
DR PDBsum; 7SS9; -.
DR PDBsum; 7SSD; -.
DR PDBsum; 7SSL; -.
DR PDBsum; 7SSN; -.
DR PDBsum; 7SSO; -.
DR PDBsum; 7SSW; -.
DR PDBsum; 7ST2; -.
DR PDBsum; 7ST6; -.
DR PDBsum; 7ST7; -.
DR AlphaFoldDB; P0A7U3; -.
DR SMR; P0A7U3; -.
DR BioGRID; 852123; 3.
DR ComplexPortal; CPX-3802; 30S small ribosomal subunit.
DR DIP; DIP-47904N; -.
DR IntAct; P0A7U3; 47.
DR STRING; 511145.b3316; -.
DR DrugBank; DB09093; Chlortetracycline.
DR DrugBank; DB12455; Omadacycline.
DR DrugBank; DB00759; Tetracycline.
DR DrugBank; DB00560; Tigecycline.
DR jPOST; P0A7U3; -.
DR PaxDb; P0A7U3; -.
DR PRIDE; P0A7U3; -.
DR EnsemblBacteria; AAC76341; AAC76341; b3316.
DR EnsemblBacteria; BAE77975; BAE77975; BAE77975.
DR GeneID; 64727507; -.
DR GeneID; 67463980; -.
DR GeneID; 947811; -.
DR KEGG; ecj:JW3278; -.
DR KEGG; eco:b3316; -.
DR PATRIC; fig|1411691.4.peg.3415; -.
DR EchoBASE; EB0911; -.
DR eggNOG; COG0185; Bacteria.
DR HOGENOM; CLU_144911_0_1_6; -.
DR InParanoid; P0A7U3; -.
DR OMA; FPEMVGH; -.
DR PhylomeDB; P0A7U3; -.
DR BioCyc; EcoCyc:EG10918-MON; -.
DR BioCyc; MetaCyc:EG10918-MON; -.
DR EvolutionaryTrace; P0A7U3; -.
DR PRO; PR:P0A7U3; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IDA:ComplexPortal.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:EcoliWiki.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0002181; P:cytoplasmic translation; IC:ComplexPortal.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR DisProt; DP00147; -.
DR Gene3D; 3.30.860.10; -; 1.
DR HAMAP; MF_00531; Ribosomal_S19; 1.
DR InterPro; IPR020934; Ribosomal_S15/S19_CS.
DR InterPro; IPR002222; Ribosomal_S19.
DR InterPro; IPR005732; Ribosomal_S19_bac-type.
DR InterPro; IPR023575; Ribosomal_S19_S15_SF.
DR PANTHER; PTHR11880; PTHR11880; 1.
DR Pfam; PF00203; Ribosomal_S19; 1.
DR PIRSF; PIRSF002144; Ribosomal_S19; 1.
DR PRINTS; PR00975; RIBOSOMALS19.
DR SUPFAM; SSF54570; SSF54570; 1.
DR TIGRFAMs; TIGR01050; rpsS_bact; 1.
DR PROSITE; PS00323; RIBOSOMAL_S19; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding;
KW tRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:348496"
FT CHAIN 2..92
FT /note="30S ribosomal protein S19"
FT /id="PRO_0000129819"
FT VARIANT 83
FT /note="H -> Y (in MW145; suppresses a rimM deletion)"
FT /evidence="ECO:0000269|PubMed:15496525"
FT CONFLICT 37..43
FT /note="RSTIFPN -> STIFPDR (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="D -> N (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT STRAND 5..7
FT /evidence="ECO:0007829|PDB:7BOH"
FT HELIX 13..16
FT /evidence="ECO:0007829|PDB:7OE0"
FT HELIX 19..21
FT /evidence="ECO:0007829|PDB:7OE0"
FT TURN 23..25
FT /evidence="ECO:0007829|PDB:7OE0"
FT STRAND 31..33
FT /evidence="ECO:0007829|PDB:7OE0"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:7OE0"
FT HELIX 42..44
FT /evidence="ECO:0007829|PDB:7OE0"
FT STRAND 48..52
FT /evidence="ECO:0007829|PDB:7OE0"
FT STRAND 54..58
FT /evidence="ECO:0007829|PDB:7OE0"
FT TURN 65..68
FT /evidence="ECO:0007829|PDB:7BOH"
FT HELIX 72..74
FT /evidence="ECO:0007829|PDB:7OE0"
SQ SEQUENCE 92 AA; 10430 MW; 439F951848E95CB8 CRC64;
MPRSLKKGPF IDLHLLKKVE KAVESGDKKP LRTWSRRSTI FPNMIGLTIA VHNGRQHVPV
FVTDEMVGHK LGEFAPTRTY RGHAADKKAK KK
