B3GN9_MOUSE
ID B3GN9_MOUSE Reviewed; 399 AA.
AC Q8VI16; Q8BK98;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 {ECO:0000250|UniProtKB:Q6UX72};
DE Short=BGnT-9 {ECO:0000250|UniProtKB:Q6UX72};
DE Short=Beta-1,3-Gn-T9;
DE Short=Beta-1,3-N-acetylglucosaminyltransferase 9;
DE Short=Beta3Gn-T9 {ECO:0000250|UniProtKB:Q6UX72};
DE EC=2.4.1.-;
GN Name=B3gnt9 {ECO:0000250|UniProtKB:Q6UX72};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAL37220.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAL37220.1};
RA Leu J.H., Chou C.M., Huang C.J.;
RT "Cloning and expression of a novel mouse beta-1,3-galactosyltransferase-
RT related gene.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:BAC27707.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC27707.1};
RC TISSUE=Embryonic kidney {ECO:0000312|EMBL:BAE41109.1},
RC Eye {ECO:0000312|EMBL:BAC35564.1}, and
RC Medulla oblongata {ECO:0000312|EMBL:BAC27707.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|EMBL:AAL37220.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAI20586.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3 {ECO:0000312|EMBL:AAI08348.1};
RC TISSUE=Brain {ECO:0000312|EMBL:AAI20584.1}, and
RC Mammary tumor {ECO:0000312|EMBL:AAI08348.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000255}; Single-
CC pass type II membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family.
CC {ECO:0000255}.
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DR EMBL; AF321826; AAL37220.1; -; Genomic_DNA.
DR EMBL; AK032108; BAC27707.1; -; mRNA.
DR EMBL; AK053867; BAC35564.1; -; mRNA.
DR EMBL; AK169360; BAE41109.1; -; mRNA.
DR EMBL; CH466525; EDL11254.1; -; Genomic_DNA.
DR EMBL; BC108347; AAI08348.1; -; mRNA.
DR EMBL; BC120583; AAI20584.1; -; mRNA.
DR EMBL; BC120585; AAI20586.1; -; mRNA.
DR CCDS; CCDS40455.1; -.
DR RefSeq; NP_001258844.1; NM_001271915.1.
DR RefSeq; NP_849210.1; NM_178879.4.
DR RefSeq; XP_006531604.1; XM_006531541.3.
DR AlphaFoldDB; Q8VI16; -.
DR SMR; Q8VI16; -.
DR STRING; 10090.ENSMUSP00000130840; -.
DR CAZy; GT31; Glycosyltransferase Family 31.
DR PhosphoSitePlus; Q8VI16; -.
DR PaxDb; Q8VI16; -.
DR PRIDE; Q8VI16; -.
DR ProteomicsDB; 265191; -.
DR Antibodypedia; 65852; 9 antibodies from 5 providers.
DR DNASU; 97440; -.
DR Ensembl; ENSMUST00000093217; ENSMUSP00000133023; ENSMUSG00000069920.
DR Ensembl; ENSMUST00000136822; ENSMUSP00000130840; ENSMUSG00000069920.
DR GeneID; 97440; -.
DR KEGG; mmu:97440; -.
DR UCSC; uc009nbx.2; mouse.
DR CTD; 84752; -.
DR MGI; MGI:2142841; B3gnt9.
DR VEuPathDB; HostDB:ENSMUSG00000069920; -.
DR eggNOG; KOG2287; Eukaryota.
DR GeneTree; ENSGT00940000162243; -.
DR HOGENOM; CLU_036849_5_2_1; -.
DR InParanoid; Q8VI16; -.
DR OMA; VAEIWLM; -.
DR OrthoDB; 1037602at2759; -.
DR PhylomeDB; Q8VI16; -.
DR TreeFam; TF318639; -.
DR Reactome; R-MMU-913709; O-linked glycosylation of mucins.
DR BioGRID-ORCS; 97440; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q8VI16; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8VI16; protein.
DR Bgee; ENSMUSG00000069920; Expressed in vault of skull and 156 other tissues.
DR ExpressionAtlas; Q8VI16; baseline and differential.
DR Genevisible; Q8VI16; MM.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0030311; P:poly-N-acetyllactosamine biosynthetic process; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR InterPro; IPR002659; Glyco_trans_31.
DR PANTHER; PTHR11214; PTHR11214; 1.
DR Pfam; PF01762; Galactosyl_T; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase; Golgi apparatus; Membrane; Reference proteome;
KW Signal-anchor; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..399
FT /note="UDP-GlcNAc:betaGal beta-1,3-N-
FT acetylglucosaminyltransferase 9"
FT /id="PRO_0000352763"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..29
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..399
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 35..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 30
FT /note="Q -> E (in Ref. 2; BAC35564)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 399 AA; 44231 MW; 265E53FF6BFDA875 CRC64;
MRRRRRPRLC PDAWLTLLLS AALGLLLYAQ RDVASPTTRP PARGPQLPRP TPSLRARELP
NTARAAPLAY EGDTPVPPTP TDPFDFGGYL RAKDQRRFPL LINQRRKCRS DGASGGSPDL
LIAVKSVAAD FERREAVRQT WGAEGRVQGA LVRRVFLLGV PKGAGSGGAG TRSHWRTLLE
AESRAYADIL LWAFEDTFFN LTLKEIHFLS WASAFCPDVH FVFKGDADVF VHVRNLLQFL
ELRDPAQDLL AGDVIVQARP IRARASKYFI PRAVYGLPVY PAYAGGGGFV LSGATLRRLA
DACSQVELFP IDDVFLGMCL QRLRLTPEPH PAFRTFGISQ PSAAPHLRTF DPCFYRELVV
VHGLSAADIW LMWRLLHGPQ GPVCAHPQPV ATGPFQWNS
