B3GNL_MOUSE
ID B3GNL_MOUSE Reviewed; 357 AA.
AC Q3U129; B7ZNC6; Q5HZJ4; Q8BLR1; Q8C0H0; Q8R1Y3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1;
DE Short=BGnT-like protein 1;
DE Short=Beta1,3-N-acetylglucosaminyltransferase-like protein 1;
DE Short=Beta3Gn-T-like protein 1;
DE Short=Beta3GnTL1;
DE EC=2.4.1.-;
GN Name=B3gntl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Brain cortex, Spleen, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative glycosyltransferase. {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3U129-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3U129-2; Sequence=VSP_025965;
CC Name=3;
CC IsoId=Q3U129-3; Sequence=VSP_025966, VSP_025967;
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
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DR EMBL; AK031361; BAC27366.1; -; mRNA.
DR EMBL; AK043722; BAC31629.1; -; mRNA.
DR EMBL; AK156318; BAE33671.1; -; mRNA.
DR EMBL; AL645972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC088993; AAH88993.1; -; mRNA.
DR EMBL; BC022739; AAH22739.1; -; mRNA.
DR EMBL; BC125626; AAI25627.1; -; mRNA.
DR EMBL; BC132193; AAI32194.1; -; mRNA.
DR EMBL; BC145166; AAI45167.1; -; mRNA.
DR CCDS; CCDS25780.1; -. [Q3U129-1]
DR RefSeq; NP_848779.2; NM_178664.5. [Q3U129-1]
DR RefSeq; XP_006532815.1; XM_006532752.3. [Q3U129-1]
DR AlphaFoldDB; Q3U129; -.
DR SMR; Q3U129; -.
DR STRING; 10090.ENSMUSP00000068590; -.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR iPTMnet; Q3U129; -.
DR PhosphoSitePlus; Q3U129; -.
DR EPD; Q3U129; -.
DR MaxQB; Q3U129; -.
DR PaxDb; Q3U129; -.
DR PRIDE; Q3U129; -.
DR ProteomicsDB; 277150; -. [Q3U129-1]
DR ProteomicsDB; 277151; -. [Q3U129-2]
DR ProteomicsDB; 277152; -. [Q3U129-3]
DR Antibodypedia; 19925; 17 antibodies from 7 providers.
DR Ensembl; ENSMUST00000062654; ENSMUSP00000049890; ENSMUSG00000046605. [Q3U129-3]
DR Ensembl; ENSMUST00000067399; ENSMUSP00000068590; ENSMUSG00000046605. [Q3U129-1]
DR GeneID; 210004; -.
DR KEGG; mmu:210004; -.
DR UCSC; uc007mwa.2; mouse. [Q3U129-1]
DR CTD; 146712; -.
DR MGI; MGI:2441705; B3gntl1.
DR VEuPathDB; HostDB:ENSMUSG00000046605; -.
DR eggNOG; KOG2977; Eukaryota.
DR GeneTree; ENSGT00390000006933; -.
DR HOGENOM; CLU_031597_0_0_1; -.
DR InParanoid; Q3U129; -.
DR OMA; MPTWFCH; -.
DR OrthoDB; 1151896at2759; -.
DR PhylomeDB; Q3U129; -.
DR TreeFam; TF315120; -.
DR Reactome; R-MMU-913709; O-linked glycosylation of mucins.
DR BioGRID-ORCS; 210004; 1 hit in 73 CRISPR screens.
DR ChiTaRS; B3gntl1; mouse.
DR PRO; PR:Q3U129; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q3U129; protein.
DR Bgee; ENSMUSG00000046605; Expressed in animal zygote and 102 other tissues.
DR Genevisible; Q3U129; MM.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycosyltransferase; Reference proteome; Transferase.
FT CHAIN 1..357
FT /note="UDP-GlcNAc:betaGal beta-1,3-N-
FT acetylglucosaminyltransferase-like protein 1"
FT /id="PRO_0000289221"
FT VAR_SEQ 111..117
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025965"
FT VAR_SEQ 238..260
FT /note="EMTIWTHRVHFLEEQVLPHWKSF -> DCSHMMVGAAVHMKQIHSKTTTV
FT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025966"
FT VAR_SEQ 261..357
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025967"
FT CONFLICT 288
FT /note="C -> S (in Ref. 1; BAC27366)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 40644 MW; 8B6A96B7CFDA3FA8 CRC64;
MEVSENATTR GSLALVSIIL PVHNAEQWLD ECLMSVLQQD FEGAMELSVF NDASKDKSRA
IIEKWKVKLE DSGISVVIGG HDSPSPRGVG YSKNQAVAQS TGSYLCFLDS DDVMMPQRVR
MQYEAAGQHP TSIIGCQVRR DPPDSTERYT RWINHLTSDQ LLTQVFTSHG PTVIMPTWFC
SRAWFSHVGP FDEGGQGVPE DLLFFYEHLR KGGGVFRVDH SLLLYRYHLY AATHSVLEMT
IWTHRVHFLE EQVLPHWKSF TIWNAGKQGR KLYRSLTAAS RHKVVAFCDV DENKIRKGFY
CYEDSQERPK PKVPILHFQA AQSPFVICVK LDLTGGEFED NLKSLDLQEG RDFVHFS
