B3GT9_HUMAN
ID B3GT9_HUMAN Reviewed; 369 AA.
AC A8MXE2;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Beta-1,3-galactosyltransferase 9;
DE EC=2.4.1.-;
DE AltName: Full=UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 10;
GN Name=B3GALT9 {ECO:0000312|HGNC:HGNC:53652}; Synonyms=B3GNT10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- FUNCTION: Putative glycosyltransferase that could catalyze the transfer
CC of galactose residues from UDP-alpha-D-galactose. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type II membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family.
CC {ECO:0000305}.
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DR EMBL; AL161911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A8MXE2; -.
DR SMR; A8MXE2; -.
DR GlyGen; A8MXE2; 3 sites.
DR BioMuta; -; -.
DR PeptideAtlas; A8MXE2; -.
DR PRIDE; A8MXE2; -.
DR Ensembl; ENST00000464488.3; ENSP00000491256.1; ENSG00000214654.9.
DR Ensembl; ENST00000689072.1; ENSP00000508889.1; ENSG00000214654.9.
DR MANE-Select; ENST00000689072.1; ENSP00000508889.1; NM_001386823.1; NP_001373752.1.
DR GeneCards; B3GALT9; -.
DR HGNC; HGNC:53652; B3GALT9.
DR HPA; ENSG00000214654; Low tissue specificity.
DR neXtProt; NX_A8MXE2; -.
DR OpenTargets; ENSG00000214654; -.
DR VEuPathDB; HostDB:ENSG00000214654; -.
DR GeneTree; ENSGT00940000162230; -.
DR OMA; VFKEVPM; -.
DR PhylomeDB; A8MXE2; -.
DR Pharos; A8MXE2; Tdark.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A8MXE2; protein.
DR Bgee; ENSG00000214654; Expressed in islet of Langerhans and 105 other tissues.
DR ExpressionAtlas; A8MXE2; baseline and differential.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR InterPro; IPR002659; Glyco_trans_31.
DR PANTHER; PTHR11214; PTHR11214; 1.
DR Pfam; PF01762; Galactosyl_T; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane;
KW Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..369
FT /note="Beta-1,3-galactosyltransferase 9"
FT /id="PRO_0000346424"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..369
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 369 AA; 42761 MW; 1532C6F62ECD853B CRC64;
MQVTFCRLRT HQWCFILFNV ILFHALLFGT DFVEEYFLHS LPYIDVKVLE IKNKARKLNI
EPLRSNLSKY YVLSQSEICK GKNIFLLSLI FSSPGNGTRR DLIRKTWGNV TSVQGHPILT
LFALGMPVSV TTQKEINKES CKNNDIIEGI FLDSSENQTL KIIAMIQWAV AFCPNALFIL
KVDEETFVNL PSLVDYLLNL KEHLEDIYVG RVLHQVTPNR DPQNRDFVPL SEYPEKYYPD
YCSGEAFIMS QDVARMMYVV FKEVPMMVPA DVFVGICAKF IGLIPIHSSR FSGKRHIRYN
RCCYKFIFTS SEIADPEMPL AWKEINDGKE CTLFETSYEL ISCKLLTYLD SFKRFHMGTI
KNNLMYFAD
