RS19_RAT
ID RS19_RAT Reviewed; 145 AA.
AC P17074;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=40S ribosomal protein S19;
GN Name=Rps19;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=2116918; DOI=10.1016/0300-9084(90)90088-x;
RA Suzuki K., Olvera J., Wool I.G.;
RT "The primary structure of rat ribosomal protein S19.";
RL Biochimie 72:299-302(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for pre-rRNA processing and maturation of 40S
CC ribosomal subunits. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RPS19BP1. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS19 family.
CC {ECO:0000305}.
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DR EMBL; X51707; CAA36003.1; -; mRNA.
DR EMBL; BC087641; AAH87641.1; -; mRNA.
DR PIR; A43770; R3RT19.
DR RefSeq; NP_001032423.1; NM_001037346.2.
DR RefSeq; XP_006228473.1; XM_006228411.1.
DR RefSeq; XP_017444775.1; XM_017589286.1.
DR RefSeq; XP_017444777.1; XM_017589288.1.
DR RefSeq; XP_017445502.1; XM_017590013.1.
DR AlphaFoldDB; P17074; -.
DR SMR; P17074; -.
DR BioGRID; 247957; 2.
DR IntAct; P17074; 6.
DR MINT; P17074; -.
DR STRING; 10116.ENSRNOP00000027246; -.
DR iPTMnet; P17074; -.
DR PhosphoSitePlus; P17074; -.
DR jPOST; P17074; -.
DR PaxDb; P17074; -.
DR PRIDE; P17074; -.
DR GeneID; 29287; -.
DR KEGG; rno:29287; -.
DR UCSC; RGD:68440; rat.
DR CTD; 6223; -.
DR RGD; 68440; Rps19.
DR VEuPathDB; HostDB:ENSRNOG00000037897; -.
DR eggNOG; KOG3411; Eukaryota.
DR HOGENOM; CLU_108559_0_1_1; -.
DR InParanoid; P17074; -.
DR OrthoDB; 1434984at2759; -.
DR PhylomeDB; P17074; -.
DR TreeFam; TF315008; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P17074; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000037897; Expressed in ovary and 19 other tissues.
DR Genevisible; P17074; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0005730; C:nucleolus; IDA:MGI.
DR GO; GO:0014069; C:postsynaptic density; ISO:RGD.
DR GO; GO:0005840; C:ribosome; ISO:RGD.
DR GO; GO:0015935; C:small ribosomal subunit; IDA:RGD.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0017134; F:fibroblast growth factor binding; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0019901; F:protein kinase binding; ISO:RGD.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:HGNC-UCL.
DR GO; GO:0031369; F:translation initiation factor binding; IPI:UniProtKB.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:RGD.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:RGD.
DR GO; GO:0030218; P:erythrocyte differentiation; ISS:HGNC-UCL.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:RGD.
DR GO; GO:0030490; P:maturation of SSU-rRNA; ISO:RGD.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISO:RGD.
DR GO; GO:0002548; P:monocyte chemotaxis; ISO:RGD.
DR GO; GO:0060266; P:negative regulation of respiratory burst involved in inflammatory response; ISO:RGD.
DR GO; GO:0007219; P:Notch signaling pathway; ISO:RGD.
DR GO; GO:0007000; P:nucleolus organization; ISO:RGD.
DR GO; GO:0060265; P:positive regulation of respiratory burst involved in inflammatory response; ISO:RGD.
DR GO; GO:0000028; P:ribosomal small subunit assembly; ISO:RGD.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:RGD.
DR GO; GO:0006364; P:rRNA processing; ISO:RGD.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001266; Ribosomal_S19e.
DR InterPro; IPR018277; Ribosomal_S19e_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11710; PTHR11710; 1.
DR Pfam; PF01090; Ribosomal_S19e; 1.
DR SMART; SM01413; Ribosomal_S19e; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00628; RIBOSOMAL_S19E; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Methylation; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..145
FT /note="40S ribosomal protein S19"
FT /id="PRO_0000153814"
FT MOD_RES 23
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P39019"
FT MOD_RES 67
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P39019"
FT MOD_RES 111
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P39019"
FT MOD_RES 115
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9CZX8"
FT MOD_RES 143
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9CZX8"
SQ SEQUENCE 145 AA; 16085 MW; 180032B887FA6E41 CRC64;
MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE NWFYTRAAST
ARHLYLRGGA GVGSMTKIYG GRQRNGVRPS HFSRGSKSVA RRVLQALEGL KMVEKDQDGG
RKLTPQGQRD LDRIAGQVAA ANKKH
