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ABCA1_DICDI
ID   ABCA1_DICDI             Reviewed;         877 AA.
AC   Q8T5Z7; Q54DT0; Q94479;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=ABC transporter A family member 1;
DE   AltName: Full=ABC transporter ABCA.1;
GN   Name=abcA1; Synonyms=abcA; ORFNames=DDB_G0291994;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC   STRAIN=AX4;
RX   PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA   Anjard C., Loomis W.F.;
RT   "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL   Eukaryot. Cell 1:643-652(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 174-828.
RC   STRAIN=AX4;
RA   Loomis W.F.;
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC       {ECO:0000305}.
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DR   EMBL; AF491005; AAL99041.1; -; Genomic_DNA.
DR   EMBL; AAFI02000187; EAL61353.1; -; Genomic_DNA.
DR   EMBL; U66526; AAB06789.2; -; mRNA.
DR   PIR; T18288; T18288.
DR   RefSeq; XP_629792.1; XM_629790.1.
DR   AlphaFoldDB; Q8T5Z7; -.
DR   SMR; Q8T5Z7; -.
DR   STRING; 44689.DDB0191222; -.
DR   TCDB; 3.A.1.211.7; the atp-binding cassette (abc) superfamily.
DR   PaxDb; Q8T5Z7; -.
DR   EnsemblProtists; EAL61353; EAL61353; DDB_G0291994.
DR   GeneID; 8628469; -.
DR   KEGG; ddi:DDB_G0291994; -.
DR   dictyBase; DDB_G0291994; abcA1.
DR   eggNOG; KOG0059; Eukaryota.
DR   HOGENOM; CLU_000604_19_5_1; -.
DR   InParanoid; Q8T5Z7; -.
DR   OMA; LAWYFEH; -.
DR   PhylomeDB; Q8T5Z7; -.
DR   Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR   Reactome; R-DDI-2453902; The canonical retinoid cycle in rods (twilight vision).
DR   Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR   Reactome; R-DDI-5683826; Surfactant metabolism.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-8963896; HDL assembly.
DR   PRO; PR:Q8T5Z7; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR   GO; GO:0030587; P:sorocarp development; IEA:UniProt.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229; PTHR19229; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..877
FT                   /note="ABC transporter A family member 1"
FT                   /id="PRO_0000363833"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        479..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          552..788
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         591..598
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   877 AA;  97375 MW;  DBEC7C7ECCB343D9 CRC64;
     MSTYSRYNDE DEIRNNKISF GDNIKREFLH LKLLLKKNLL VSIRSYFSTG IEILSPIAFI
     IILFLISHFG SGNENPIVTY NQELPICKSY GENRCFNIMF SPSNSPSAIA IMEMLGEINN
     NSIYSYPSDT GYLPDLNNTI GLKGGLIMMN SIEDSFEFVL AHPNVTIAAV DFLSIPLGFQ
     INGAPPKNEP LLKMDGNSLE FNVVVNTTCP NILATCPDYS IAITTAIEKA VITYYSQKIR
     NEKIPPPTIS YGSNAFPRYP PEQGAARVWG GLFYYCGSMI SFIFLLYKVS FEKENKLKQG
     MVMMGLSVNQ YWISWFITSF TIDILISLIT IIVGLACQLP FFLGSNFFVL IITFSLFTIS
     MSSVAFFLLT FIQSTKSAIG IGMGIFIVGS IFQLVFSGMG TMIFELIYQT NSNGALAARI
     ILFFIPMFHF TKVLTDIGNV TTNYPLLTYK FSDLSTDLNI GGTVLKTVIP TTGQSICYLL
     ALIGVYTVLA WYFEHIIPGN DGTSSPPWFF VLPSYWGLSL KKVRHIPTPY FDDEDVRAAI
     TKAHDASNRA PLIICGLSKS YTKLFRPKKT VHAVKYLSLS VEKGTILGFL GSNGCGKSTT
     IGMLTGLLEP TAGDALVYGH SVISNIAAVR RITSVVPQHD ILWAEMTARE HLQLFSELKG
     IPAQERESQI QKVLDQVRLS KISNNLISTY SGGMKRRLSV AIACIGDPKI IFMDEPTTGV
     DPSSKRHLID LVKSIKNDKV IILTSHDMHE VEILADKIVI MNEGVMACNG NSLQLKSKYG
     EGYSVNIVAK SPESIPAVVE FVTLSIPGCK FMKQSALQLN FGFPVTIDHQ IIANFFKQLE
     EITNDPNNQL MRDWSVSHST LDDVFLKVSH LAKLKTQ
 
 
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