B561C_ARATH
ID B561C_ARATH Reviewed; 393 AA.
AC Q9LSE7;
DT 01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Cytochrome b561 and DOMON domain-containing protein At3g25290;
DE AltName: Full=Protein b561A.tha3;
DE Flags: Precursor;
GN OrderedLocusNames=At3g25290; ORFNames=MJL12_25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP DOMAIN, AND FUNCTION.
RX PubMed=15022831; DOI=10.1078/0176-1617-01064;
RA Verelst W., Asard H.;
RT "Analysis of an Arabidopsis thaliana protein family, structurally related
RT to cytochromes b561 and potentially involved in catecholamine biochemistry
RT in plants.";
RL J. Plant Physiol. 161:175-181(2004).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16169296; DOI=10.1016/j.bbapap.2005.08.015;
RA Tsubaki M., Takeuchi F., Nakanishi N.;
RT "Cytochrome b561 protein family: expanding roles and versatile
RT transmembrane electron transfer abilities as predicted by a new
RT classification system and protein sequence motif analyses.";
RL Biochim. Biophys. Acta 1753:174-190(2005).
RN [6]
RP DOMAIN.
RX PubMed=19386804; DOI=10.1104/pp.109.139170;
RA Preger V., Tango N., Marchand C., Lemaire S.D., Carbonera D.,
RA Di Valentin M., Costa A., Pupillo P., Trost P.;
RT "Auxin-responsive genes AIR12 code for a new family of plasma membrane b-
RT type cytochromes specific to flowering plants.";
RL Plant Physiol. 150:606-620(2009).
RN [7]
RP REVIEW.
RX PubMed=23249217; DOI=10.1089/ars.2012.5065;
RA Asard H., Barbaro R., Trost P., Berczi A.;
RT "Cytochromes b561: ascorbate-mediated trans-membrane electron transport.";
RL Antioxid. Redox Signal. 19:1026-1035(2013).
CC -!- FUNCTION: May act as a catecholamine-responsive trans-membrane electron
CC transporter. {ECO:0000269|PubMed:15022831}.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000250|UniProtKB:Q9SWS1};
CC Note=Binds 2 heme b groups non-covalently.
CC {ECO:0000250|UniProtKB:Q9SWS1};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: DOMON domain could bind catecholamines and thereby could
CC regulate the cytochrome b561 domain function (PubMed:15022831). DOMON
CC domain could bind one heme b (PubMed:19386804).
CC {ECO:0000269|PubMed:15022831, ECO:0000269|PubMed:19386804}.
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DR EMBL; AB026647; BAB02088.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77005.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77006.1; -; Genomic_DNA.
DR EMBL; AY057704; AAL15334.1; -; mRNA.
DR EMBL; BT002214; AAN72226.1; -; mRNA.
DR RefSeq; NP_001030764.1; NM_001035687.1.
DR RefSeq; NP_566763.1; NM_113435.3.
DR AlphaFoldDB; Q9LSE7; -.
DR SMR; Q9LSE7; -.
DR BioGRID; 7454; 2.
DR STRING; 3702.AT3G25290.1; -.
DR iPTMnet; Q9LSE7; -.
DR PaxDb; Q9LSE7; -.
DR PRIDE; Q9LSE7; -.
DR ProteomicsDB; 241188; -.
DR EnsemblPlants; AT3G25290.1; AT3G25290.1; AT3G25290.
DR EnsemblPlants; AT3G25290.2; AT3G25290.2; AT3G25290.
DR GeneID; 822123; -.
DR Gramene; AT3G25290.1; AT3G25290.1; AT3G25290.
DR Gramene; AT3G25290.2; AT3G25290.2; AT3G25290.
DR KEGG; ath:AT3G25290; -.
DR Araport; AT3G25290; -.
DR TAIR; locus:2090240; AT3G25290.
DR eggNOG; KOG4293; Eukaryota.
DR HOGENOM; CLU_036675_1_0_1; -.
DR InParanoid; Q9LSE7; -.
DR OMA; FTLATIQ; -.
DR OrthoDB; 599276at2759; -.
DR PhylomeDB; Q9LSE7; -.
DR PRO; PR:Q9LSE7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LSE7; baseline and differential.
DR Genevisible; Q9LSE7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09629; DOMON_CIL1_like; 1.
DR InterPro; IPR045265; AIR12_DOMON.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR017214; UCP037471.
DR Pfam; PF03188; Cytochrom_B561; 1.
DR Pfam; PF04526; DUF568; 1.
DR PIRSF; PIRSF037471; UCP037471; 1.
DR SMART; SM00665; B561; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
DR PROSITE; PS50836; DOMON; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Heme; Iron; Membrane; Metal-binding;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..393
FT /note="Cytochrome b561 and DOMON domain-containing protein
FT At3g25290"
FT /id="PRO_0000430474"
FT TRANSMEM 219..239
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT DOMAIN 48..168
FT /note="DOMON"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00246"
FT DOMAIN 184..380
FT /note="Cytochrome b561"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00242"
FT BINDING 220
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_label="1"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250|UniProtKB:Q9SWS1"
FT BINDING 256
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_label="2"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250|UniProtKB:Q9SWS1"
FT BINDING 289
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_label="1"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250|UniProtKB:Q9SWS1"
FT BINDING 325
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_label="2"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250|UniProtKB:Q9SWS1"
SQ SEQUENCE 393 AA; 42559 MW; E3229A63BE01C55E CRC64;
MSSSSSVRIS LSFIFLALLI SPAVSQTCKS QTFSGDKTYP HCLDLPQLKA FLHYSYDASN
TTLAVVFSAP PAKPGGWIAW AINPKATGMV GSQTLVAYKD PGNGVAVVKT LNISSYSSLI
PSKLAFDVWD MKAEEAARDG GSLRIFARVK VPADLVAKGK VNQVWQVGPE LGPGGMIGRH
AFDSANLASM SSLDLKGDNS GGTISGGDEV NAKIKNRNIH GILNAVSWGI LFPIGAIIAR
YMRVFDSADP AWFYLHVSCQ FSAYVIGVAG WATGLKLGNE SEGIRFSAHR NIGIALFTLA
TIQMFAMLLR PKKDHKYRFY WNIYHHGVGY AILTLGIINV FKGLNILKPQ DTYKTAYIAV
IAVLGGIALL LEAITWVVVL KRKSNNSMKP LRT
