B561Q_ARATH
ID B561Q_ARATH Reviewed; 255 AA.
AC Q9FKC1;
DT 01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Cytochrome b561 and DOMON domain-containing protein At5g48750;
DE AltName: Full=Protein b561A.tha17;
DE Flags: Precursor;
GN OrderedLocusNames=At5g48750; ORFNames=K24G6.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP DOMAIN.
RX PubMed=15022831; DOI=10.1078/0176-1617-01064;
RA Verelst W., Asard H.;
RT "Analysis of an Arabidopsis thaliana protein family, structurally related
RT to cytochromes b561 and potentially involved in catecholamine biochemistry
RT in plants.";
RL J. Plant Physiol. 161:175-181(2004).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16169296; DOI=10.1016/j.bbapap.2005.08.015;
RA Tsubaki M., Takeuchi F., Nakanishi N.;
RT "Cytochrome b561 protein family: expanding roles and versatile
RT transmembrane electron transfer abilities as predicted by a new
RT classification system and protein sequence motif analyses.";
RL Biochim. Biophys. Acta 1753:174-190(2005).
RN [6]
RP DOMAIN.
RX PubMed=19386804; DOI=10.1104/pp.109.139170;
RA Preger V., Tango N., Marchand C., Lemaire S.D., Carbonera D.,
RA Di Valentin M., Costa A., Pupillo P., Trost P.;
RT "Auxin-responsive genes AIR12 code for a new family of plasma membrane b-
RT type cytochromes specific to flowering plants.";
RL Plant Physiol. 150:606-620(2009).
RN [7]
RP REVIEW.
RX PubMed=23249217; DOI=10.1089/ars.2012.5065;
RA Asard H., Barbaro R., Trost P., Berczi A.;
RT "Cytochromes b561: ascorbate-mediated trans-membrane electron transport.";
RL Antioxid. Redox Signal. 19:1026-1035(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: DOMON domain could bind catecholamines (PubMed:15022831). DOMON
CC domain could bind one heme b (PubMed:19386804).
CC {ECO:0000269|PubMed:15022831, ECO:0000269|PubMed:19386804}.
CC -!- CAUTION: Lacks the C-terminal part of the cytochrome b561 domain, which
CC contains the residues coordinating the two heme molecules and 4 of the
CC 6 conserved transmembrane regions. {ECO:0000305}.
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DR EMBL; AB012242; BAB09428.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95719.1; -; Genomic_DNA.
DR EMBL; DQ056711; AAY78857.1; -; mRNA.
DR RefSeq; NP_199686.1; NM_124252.1.
DR AlphaFoldDB; Q9FKC1; -.
DR PaxDb; Q9FKC1; -.
DR PRIDE; Q9FKC1; -.
DR EnsemblPlants; AT5G48750.1; AT5G48750.1; AT5G48750.
DR GeneID; 834933; -.
DR Gramene; AT5G48750.1; AT5G48750.1; AT5G48750.
DR KEGG; ath:AT5G48750; -.
DR Araport; AT5G48750; -.
DR TAIR; locus:2156559; AT5G48750.
DR eggNOG; KOG4293; Eukaryota.
DR HOGENOM; CLU_036675_2_0_1; -.
DR InParanoid; Q9FKC1; -.
DR OMA; KVFTSCR; -.
DR OrthoDB; 599276at2759; -.
DR PhylomeDB; Q9FKC1; -.
DR PRO; PR:Q9FKC1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKC1; differential.
DR Genevisible; Q9FKC1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd09629; DOMON_CIL1_like; 1.
DR InterPro; IPR045265; AIR12_DOMON.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR017214; UCP037471.
DR Pfam; PF04526; DUF568; 1.
DR PIRSF; PIRSF037471; UCP037471; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
DR PROSITE; PS50836; DOMON; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..255
FT /note="Cytochrome b561 and DOMON domain-containing protein
FT At5g48750"
FT /id="PRO_0000430484"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 54..169
FT /note="DOMON"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00246"
FT DOMAIN 176..255
FT /note="Cytochrome b561"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00242"
SQ SEQUENCE 255 AA; 28605 MW; 02421DAD28B8E9B0 CRC64;
MFLSSRTIFV GLCFLFVLAP CFTRATTNEV QVSCDSHNFN NGKHFRSCVD LPVLDSFLHY
SYVRETGVLE VAYRHTNIES SSWIAWGINP TSKGMIGAQT LLAYRNSTSG FMRAYTSSIN
GYTPMLQEGP LSFRVTQLSA EYLNREMTIF ATMVWPSNTT VVNHLWQDGP LKEGDRLGMH
AMSGNHLKSM ANLDLLSGQV MTTKAANDNM LLVKSIHGLV NAVCWGIFIP IGVMAARYMR
TYKGLDPTWF YILIL
