ID   B5_USTMD                Reviewed;         410 AA.
AC   P22019;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Mating-type locus allele B5 protein;
OS   Ustilago maydis (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=5270;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 22907 / 48;
RX   PubMed=2227416; DOI=10.1101/gad.4.8.1384;
RA   Kronstad J.W., Leong S.A.;
RT   "The b mating-type locus of Ustilago maydis contains variable and constant
RT   regions.";
RL   Genes Dev. 4:1384-1395(1990).
CC   -!- FUNCTION: The B locus has at least 25 alleles, and any combination of
CC       two different B alleles yields a multimeric regulatory protein, that
CC       activates genes responsible for the pathogenicity and for the sexual
CC       development of the fungus within the corn plant.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TALE/M-ATYP homeobox family. {ECO:0000305}.
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DR   EMBL; X53901; CAA37869.1; -; Genomic_DNA.
DR   EMBL; X54069; CAA38000.1; -; Genomic_DNA.
DR   PIR; D36671; D36671.
DR   AlphaFoldDB; P22019; -.
DR   SMR; P22019; -.
DR   VEuPathDB; FungiDB:UMAG_12052; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR008888; Ustilago_mating.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF05722; Ustilago_mating; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..410
FT                   /note="Mating-type locus allele B5 protein"
FT                   /id="PRO_0000049405"
FT   DNA_BIND        107..184
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..110
FT                   /note="Variable domain between B alleles"
FT   REGION          111..410
FT                   /note="Highly conserved between B alleles"
FT   REGION          201..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..410
FT                   /note="Not essential for B5 function"
FT   REGION          366..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           276..308
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        202..229
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   410 AA;  46305 MW;  6A60A2E182F03103 CRC64;
     MSSDPNFSLT SFLECLNEIE HEFLRDKEEN RPIIVRKLRE LQQKTPNHVA DLAHDSKTIE
     QIHQTAHRIK VAVKTFIRID QKFVSLCSEV VHGTSKVMEE FNVVSPAVVC RNLSEDLPAY
     HMRKHFLLTL DNPYPTQEEK QNLVRLTNES TVRVGSSNPA RPPLEVHQLT LWFINARRRS
     GWSHILKKFA REDRSRMKHL VRAKLSSSNQ STPPSPTSEY PSNNLDDFLS DNLGRPLTPA
     DKQQFEDDWA SMISWIKYGV KEKVGDWVYD LCAANKKTPK PGMPRPVTTV TKRQPARKTK
     PAAKPKSRTA NPRASTTPSI DSTLDSSKLE STPELSMCST ADTSFSTFGS SLSMSHYNPF
     QDGNDILQSP TVKARGNRKV KALPKRAGKQ QPDEVDNGKI PFLCLSVAFV