B6_USTMD
ID B6_USTMD Reviewed; 410 AA.
AC P22020;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Mating-type locus allele B6 protein;
OS Ustilago maydis (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=5270;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 22505 / 50;
RX PubMed=2227416; DOI=10.1101/gad.4.8.1384;
RA Kronstad J.W., Leong S.A.;
RT "The b mating-type locus of Ustilago maydis contains variable and constant
RT regions.";
RL Genes Dev. 4:1384-1395(1990).
CC -!- FUNCTION: The B locus has at least 25 alleles, and any combination of
CC two different B alleles yields a multimeric regulatory protein, that
CC activates genes responsible for the pathogenicity and for the sexual
CC development of the fungus within the corn plant.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the TALE/M-ATYP homeobox family. {ECO:0000305}.
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DR EMBL; X53902; CAA37870.1; -; Genomic_DNA.
DR EMBL; X54071; CAA38002.1; -; Genomic_DNA.
DR PIR; E36671; E36671.
DR AlphaFoldDB; P22020; -.
DR SMR; P22020; -.
DR VEuPathDB; FungiDB:UMAG_12052; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR008888; Ustilago_mating.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF05722; Ustilago_mating; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Homeobox; Nucleus.
FT CHAIN 1..410
FT /note="Mating-type locus allele B6 protein"
FT /id="PRO_0000049406"
FT DNA_BIND 107..184
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..110
FT /note="Variable domain between B alleles"
FT REGION 111..410
FT /note="Highly conserved between B alleles"
FT REGION 202..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..410
FT /note="Not essential for B6 function"
FT REGION 373..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 276..308
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 202..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 46517 MW; 295AF9A14DE781F4 CRC64;
MSRDPKLSLS KFLECLNEIE HEFLRDKVEH RPVLVRKLQE LQQKTPKHVT NLPNDPETIQ
QIHQIAHRLE VAVKVFLHID RKFVSLRSDV VEDTSKALQE VNVASPAVEY RNLSEDLPAY
HMRKHFLHTL DSPYPTQEEK ETLVRLTNES TARVGQSSVN RPPLEVHQLT LWFINARRRS
GWSHILKKFA REDRSRMKHL VRAKLSSSNQ STPPSLTSEK PSDDLDVVLS DNLGRPLTLA
DKQQFEDDWA SMISWIKYGV KEKVGDWVYD LCAASKKTPK PGMPRPVTTV AKRQPARKTK
PAAKPKSRTA NPRASTTPSI DSTLDSSKLE STPELSMCST ADTSFSTFGS SLSMSHYDPF
QYGNDILQSP TFKARGNRKV KALPKRAGKQ QPDEIDNGKI PFFCLSIAFV