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B6_USTMD
ID   B6_USTMD                Reviewed;         410 AA.
AC   P22020;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Mating-type locus allele B6 protein;
OS   Ustilago maydis (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=5270;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 22505 / 50;
RX   PubMed=2227416; DOI=10.1101/gad.4.8.1384;
RA   Kronstad J.W., Leong S.A.;
RT   "The b mating-type locus of Ustilago maydis contains variable and constant
RT   regions.";
RL   Genes Dev. 4:1384-1395(1990).
CC   -!- FUNCTION: The B locus has at least 25 alleles, and any combination of
CC       two different B alleles yields a multimeric regulatory protein, that
CC       activates genes responsible for the pathogenicity and for the sexual
CC       development of the fungus within the corn plant.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TALE/M-ATYP homeobox family. {ECO:0000305}.
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DR   EMBL; X53902; CAA37870.1; -; Genomic_DNA.
DR   EMBL; X54071; CAA38002.1; -; Genomic_DNA.
DR   PIR; E36671; E36671.
DR   AlphaFoldDB; P22020; -.
DR   SMR; P22020; -.
DR   VEuPathDB; FungiDB:UMAG_12052; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR008888; Ustilago_mating.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF05722; Ustilago_mating; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..410
FT                   /note="Mating-type locus allele B6 protein"
FT                   /id="PRO_0000049406"
FT   DNA_BIND        107..184
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..110
FT                   /note="Variable domain between B alleles"
FT   REGION          111..410
FT                   /note="Highly conserved between B alleles"
FT   REGION          202..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..410
FT                   /note="Not essential for B6 function"
FT   REGION          373..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           276..308
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        202..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   410 AA;  46517 MW;  295AF9A14DE781F4 CRC64;
     MSRDPKLSLS KFLECLNEIE HEFLRDKVEH RPVLVRKLQE LQQKTPKHVT NLPNDPETIQ
     QIHQIAHRLE VAVKVFLHID RKFVSLRSDV VEDTSKALQE VNVASPAVEY RNLSEDLPAY
     HMRKHFLHTL DSPYPTQEEK ETLVRLTNES TARVGQSSVN RPPLEVHQLT LWFINARRRS
     GWSHILKKFA REDRSRMKHL VRAKLSSSNQ STPPSLTSEK PSDDLDVVLS DNLGRPLTLA
     DKQQFEDDWA SMISWIKYGV KEKVGDWVYD LCAASKKTPK PGMPRPVTTV AKRQPARKTK
     PAAKPKSRTA NPRASTTPSI DSTLDSSKLE STPELSMCST ADTSFSTFGS SLSMSHYDPF
     QYGNDILQSP TFKARGNRKV KALPKRAGKQ QPDEIDNGKI PFFCLSIAFV
 
 
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