RS20_RAT
ID RS20_RAT Reviewed; 119 AA.
AC P60868; P17075;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=40S ribosomal protein S20;
GN Name=Rps20;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=2357470; DOI=10.1016/0167-4781(90)90088-j;
RA Chan Y.-L., Wool I.G.;
RT "The primary structure of rat ribosomal protein S20.";
RL Biochim. Biophys. Acta 1049:93-95(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Component of the 40S small ribosomal subunit. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Monoubiquitinated by ZNF598 when a ribosome has stalled during
CC translation of poly(A) sequences, leading to preclude synthesis of a
CC long poly-lysine tail and initiate the ribosome quality control (RQC)
CC pathway to degrade the potentially detrimental aberrant nascent
CC polypeptide. {ECO:0000250|UniProtKB:P60866}.
CC -!- PTM: Ufmylated by UFL1. {ECO:0000250|UniProtKB:P60867}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS10 family.
CC {ECO:0000305}.
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DR EMBL; X51537; CAA35917.1; -; mRNA.
DR EMBL; BC058496; AAH58496.1; -; mRNA.
DR PIR; S14682; R3RT20.
DR RefSeq; NP_001007604.1; NM_001007603.2.
DR RefSeq; XP_002726693.1; XM_002726647.4.
DR RefSeq; XP_002727194.1; XM_002727148.5.
DR RefSeq; XP_002729204.1; XM_002729158.5.
DR RefSeq; XP_002729620.1; XM_002729574.4.
DR RefSeq; XP_002730040.1; XM_002729994.5.
DR RefSeq; XP_003753765.1; XM_003753717.4.
DR AlphaFoldDB; P60868; -.
DR SMR; P60868; -.
DR BioGRID; 250778; 8.
DR IntAct; P60868; 5.
DR MINT; P60868; -.
DR STRING; 10116.ENSRNOP00000065886; -.
DR iPTMnet; P60868; -.
DR PhosphoSitePlus; P60868; -.
DR jPOST; P60868; -.
DR PaxDb; P60868; -.
DR PRIDE; P60868; -.
DR Ensembl; ENSRNOT00000011314; ENSRNOP00000011314; ENSRNOG00000008555.
DR Ensembl; ENSRNOT00000040481; ENSRNOP00000066077; ENSRNOG00000071148.
DR Ensembl; ENSRNOT00000041813; ENSRNOP00000065886; ENSRNOG00000029627.
DR Ensembl; ENSRNOT00000051449; ENSRNOP00000069127; ENSRNOG00000030345.
DR GeneID; 100359951; -.
DR GeneID; 100362149; -.
DR GeneID; 100362684; -.
DR GeneID; 122772; -.
DR KEGG; rno:100359951; -.
DR KEGG; rno:100362149; -.
DR KEGG; rno:100362684; -.
DR KEGG; rno:122772; -.
DR UCSC; RGD:621037; rat.
DR CTD; 6224; -.
DR RGD; 621037; Rps20.
DR eggNOG; KOG0900; Eukaryota.
DR GeneTree; ENSGT00390000003248; -.
DR HOGENOM; CLU_122625_0_0_1; -.
DR InParanoid; P60868; -.
DR OMA; MANIKKD; -.
DR OrthoDB; 1454256at2759; -.
DR PhylomeDB; P60868; -.
DR TreeFam; TF300222; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P60868; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Proteomes; UP000002494; Chromosome 5.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000029627; Expressed in thymus and 19 other tissues.
DR Genevisible; P60868; RN.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0015935; C:small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0097371; F:MDM2/MDM4 family protein binding; ISO:RGD.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:1990948; F:ubiquitin ligase inhibitor activity; ISO:RGD.
DR GO; GO:1901798; P:positive regulation of signal transduction by p53 class mediator; ISO:RGD.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.30.70.600; -; 1.
DR HAMAP; MF_00508; Ribosomal_S10; 1.
DR InterPro; IPR001848; Ribosomal_S10.
DR InterPro; IPR018268; Ribosomal_S10_CS.
DR InterPro; IPR027486; Ribosomal_S10_dom.
DR InterPro; IPR036838; Ribosomal_S10_dom_sf.
DR InterPro; IPR005729; Ribosomal_S10_euk/arc.
DR PANTHER; PTHR11700; PTHR11700; 1.
DR Pfam; PF00338; Ribosomal_S10; 1.
DR PRINTS; PR00971; RIBOSOMALS10.
DR SMART; SM01403; Ribosomal_S10; 1.
DR SUPFAM; SSF54999; SSF54999; 1.
DR TIGRFAMs; TIGR01046; uS10_euk_arch; 1.
DR PROSITE; PS00361; RIBOSOMAL_S10; 1.
PE 3: Inferred from homology;
KW Acetylation; Cytoplasm; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P60866"
FT CHAIN 2..119
FT /note="40S ribosomal protein S20"
FT /id="PRO_0000146685"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P60866"
FT MOD_RES 8
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P60867"
FT MOD_RES 9
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P60866"
FT MOD_RES 34
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P60867"
FT MOD_RES 75
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P60867"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P60866"
FT CROSSLNK 4
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:P60866"
FT CROSSLNK 8
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin); alternate"
FT /evidence="ECO:0000250|UniProtKB:P60866"
SQ SEQUENCE 119 AA; 13373 MW; 8802DF7894ADDF94 CRC64;
MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV KGPVRMPTKT
LRITTRKTPC GEGSKTWDRF QMRIHKRLID LHSPSEIVKQ ITSISIEPGV EVEVTIADA
