ID   B8_VACCC                Reviewed;         272 AA.
AC   P21004;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Soluble interferon gamma receptor B8;
DE            Short=B8;
DE   Flags: Precursor;
GN   ORFNames=B8R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Counteracts the antiviral effects of host IFN-gamma. Acts as
CC       a soluble IFN-gamma receptor and thus inhibits the interaction between
CC       host IFN-gamma and its receptor (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with host IFNG (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48205.1; -; Genomic_DNA.
DR   PIR; G42526; G42526.
DR   SMR; P21004; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR021126; IFN_gamma_rc_D2_pox/mammal.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF07140; IFNGR1; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
PE   3: Inferred from homology;
KW   Glycoprotein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Reference proteome; Secreted; Signal; Viral immunoevasion.
FT   SIGNAL          1..13
FT                   /evidence="ECO:0000255"
FT   CHAIN           14..272
FT                   /note="Soluble interferon gamma receptor B8"
FT                   /id="PRO_0000040608"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        150
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        267
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   272 AA;  31163 MW;  26E80C169167D875 CRC64;
     MRYIIILAVL FINSIHAKIT SYKFESVNFD SKIEWTGDGL YNISLKNYGI KTWQTMYTNV
     PEGTYDISAF PKNDFVSFWV KFEQGDYKVE EYCTGLCVEV KIGPPTVTLT EYDDHINLYI
     EHPYATRGSK KIPIYKRGDM CDIYLLYTAN FTFGDSEEPV TYDIDDYDCT STGCSIDFAT
     TEKVCVTAQG ATEGFLEKIT PWSSEVCLTP KKNVYTCAIR SKEDVPNFKD KMARVIKRKF
     NKQSQSYLTK FLGSTSNDVT TFLSMLNLTK YS