ID   B8_VACCW                Reviewed;         272 AA.
AC   P24770; Q76ZL5;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Soluble interferon gamma receptor B8;
DE            Short=B8;
DE   Flags: Precursor;
GN   OrderedLocusNames=VACWR190; ORFNames=B8R;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2045793; DOI=10.1099/0022-1317-72-6-1349;
RA   Smith G.L., Chan Y.S., Howard S.T.;
RT   "Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the
RT   right inverted terminal repeat.";
RL   J. Gen. Virol. 72:1349-1376(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1846491; DOI=10.1016/0042-6822(91)90077-o;
RA   Howard S.T., Chan Y.S., Smith G.L.;
RT   "Vaccinia virus homologues of the Shope fibroma virus inverted terminal
RT   repeat proteins and a discontinuous ORF related to the tumor necrosis
RT   factor receptor family.";
RL   Virology 180:633-647(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   INTERACTION WITH HOST IFNG.
RX   PubMed=7609027; DOI=10.1128/jvi.69.8.4633-4639.1995;
RA   Alcami A., Smith G.L.;
RT   "Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon
RT   receptors with novel broad species specificity.";
RL   J. Virol. 69:4633-4639(1995).
RN   [5]
RP   SUBCELLULAR LOCATION, AND SUBUNIT.
RX   PubMed=7747448; DOI=10.1006/viro.1995.1208;
RA   Mossman K., Upton C., Buller R.M., McFadden G.;
RT   "Species specificity of ectromelia virus and vaccinia virus interferon-
RT   gamma binding proteins.";
RL   Virology 208:762-769(1995).
RN   [6]
RP   FUNCTION.
RX   PubMed=12124459; DOI=10.1099/0022-1317-83-8-1953;
RA   Symons J.A., Tscharke D.C., Price N., Smith G.L.;
RT   "A study of the vaccinia virus interferon-gamma receptor and its
RT   contribution to virus virulence.";
RL   J. Gen. Virol. 83:1953-1964(2002).
CC   -!- FUNCTION: Counteracts the antiviral effects of host IFN-gamma. Acts as
CC       a soluble IFN-gamma receptor and thus inhibits the interaction between
CC       host IFN-gamma and its receptor. {ECO:0000269|PubMed:12124459}.
CC   -!- SUBUNIT: Homodimer. Interacts with host IFNG.
CC       {ECO:0000269|PubMed:7609027, ECO:0000269|PubMed:7747448}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7747448}.
CC   -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D11079; BAA01838.1; -; Genomic_DNA.
DR   EMBL; M58056; AAA47967.1; -; Genomic_DNA.
DR   EMBL; AY243312; AAO89469.1; -; Genomic_DNA.
DR   PIR; JQ1802; JQ1802.
DR   RefSeq; YP_233072.1; NC_006998.1.
DR   SMR; P24770; -.
DR   IntAct; P24770; 1.
DR   DNASU; 3707661; -.
DR   GeneID; 3707661; -.
DR   KEGG; vg:3707661; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR021126; IFN_gamma_rc_D2_pox/mammal.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF07140; IFNGR1; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
PE   1: Evidence at protein level;
KW   Glycoprotein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Reference proteome; Secreted; Signal; Viral immunoevasion.
FT   SIGNAL          1..13
FT                   /evidence="ECO:0000255"
FT   CHAIN           14..272
FT                   /note="Soluble interferon gamma receptor B8"
FT                   /id="PRO_0000040609"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        150
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        267
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   272 AA;  31159 MW;  3C7ED994A82DDB93 CRC64;
     MRYIIILAVL FINSIHAKIT SYKFESVNFD SKIEWTGDGL YNISLKNYGI KTWQTMYTNV
     PEGTYDISAF PKNDFVSFWV KFEQGDYKVE EYCTGLCVEV KIGPPTVTLT EYDDHINLYI
     EHPYATRGSK KIPIYKRGDM CDIYLLYTAN FTFGDSKEPV PYDIDDYDCT STGCSIDFVT
     TEKVCVTAQG ATEGFLEKIT PWSSKVCLTP KKSVYTCAIR SKEDVPNFKD KMARVIKRKF
     NKQSQSYLTK FLGSTSNDVT TFLSMLNLTK YS