ID   B9D1_DANRE              Reviewed;         201 AA.
AC   Q503B7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=B9 domain-containing protein 1;
GN   Name=b9d1; ORFNames=zgc:110733;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the tectonic-like complex, a complex localized
CC       at the transition zone of primary cilia and acting as a barrier that
CC       prevents diffusion of transmembrane proteins between the cilia and
CC       plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH
CC       signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Note=Localizes at the transition zone, a region between
CC       the basal body and the ciliary axoneme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the B9D family. {ECO:0000305}.
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DR   EMBL; BC095392; AAH95392.1; -; mRNA.
DR   RefSeq; NP_001019544.1; NM_001024373.1.
DR   AlphaFoldDB; Q503B7; -.
DR   STRING; 7955.ENSDARP00000108593; -.
DR   PaxDb; Q503B7; -.
DR   GeneID; 554150; -.
DR   KEGG; dre:554150; -.
DR   CTD; 27077; -.
DR   ZFIN; ZDB-GENE-050522-467; b9d1.
DR   eggNOG; KOG4027; Eukaryota.
DR   InParanoid; Q503B7; -.
DR   OrthoDB; 1387644at2759; -.
DR   PhylomeDB; Q503B7; -.
DR   Reactome; R-DRE-5620912; Anchoring of the basal body to the plasma membrane.
DR   PRO; PR:Q503B7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0008158; F:hedgehog receptor activity; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR010796; C2_B9-type_dom.
DR   PANTHER; PTHR12968; PTHR12968; 1.
DR   Pfam; PF07162; B9-C2; 1.
DR   PROSITE; PS51381; C2_B9; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..201
FT                   /note="B9 domain-containing protein 1"
FT                   /id="PRO_0000307670"
FT   DOMAIN          9..126
FT                   /note="C2 B9-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00713"
SQ   SEQUENCE   201 AA;  22513 MW;  09EB2D2D07826908 CRC64;
     MTSNNPAVFL LMVNGQIESA DFPEYDDLYC KYCFVYGHDW APTSGLEEGI SQITSKGRLS
     QSLVWNFPLD ITFKSTNPFG WPQIVVSVYG PDTFGNDVVR GYGAVHIPFT PGKHTKTIPM
     FVPESTSRLQ KFTSWLMGRR PEFTDPKVVA QGEGREVTRV RSQGFVTLQF NIVTKDMKKL
     GYDTTSTEHS PAGLTRASQQ L