ID   B9D1_RAT                Reviewed;         204 AA.
AC   P0C5J2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=B9 domain-containing protein 1;
DE   AltName: Full=Endothelial precursor cells protein B9;
GN   Name=B9d1; Synonyms=Eppb9;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RA   Lee N.H., Glodek A., Chandra I., Mason T.M., Quackenbush J.,
RA   Kerlavage A.R., Adams M.D.;
RT   "Rat genome project: generation of a rat EST (REST) catalog & rat gene
RT   index.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the tectonic-like complex, a complex localized
CC       at the transition zone of primary cilia and acting as a barrier that
CC       prevents diffusion of transmembrane proteins between the cilia and
CC       plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH
CC       signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Note=Localizes at the transition zone, a region between
CC       the basal body and the ciliary axoneme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the B9D family. {ECO:0000305}.
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DR   EMBL; AW915603; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001099256.1; NM_001105786.1.
DR   RefSeq; XP_017453132.1; XM_017597643.1.
DR   RefSeq; XP_017459566.1; XM_017604077.1.
DR   AlphaFoldDB; P0C5J2; -.
DR   STRING; 10116.ENSRNOP00000003402; -.
DR   PaxDb; P0C5J2; -.
DR   GeneID; 287383; -.
DR   KEGG; rno:287383; -.
DR   UCSC; RGD:1305522; rat.
DR   CTD; 27077; -.
DR   RGD; 1305522; B9d1.
DR   VEuPathDB; HostDB:ENSRNOG00000002462; -.
DR   eggNOG; KOG4027; Eukaryota.
DR   HOGENOM; CLU_084934_0_0_1; -.
DR   InParanoid; P0C5J2; -.
DR   OMA; GWPQILV; -.
DR   OrthoDB; 1387644at2759; -.
DR   PhylomeDB; P0C5J2; -.
DR   Reactome; R-RNO-5620912; Anchoring of the basal body to the plasma membrane.
DR   PRO; PR:P0C5J2; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000002462; Expressed in ovary and 19 other tissues.
DR   ExpressionAtlas; P0C5J2; baseline.
DR   Genevisible; P0C5J2; RN.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0008158; F:hedgehog receptor activity; ISS:UniProtKB.
DR   GO; GO:0043010; P:camera-type eye development; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0060563; P:neuroepithelial cell differentiation; ISO:RGD.
DR   GO; GO:0032880; P:regulation of protein localization; ISO:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   GO; GO:0001944; P:vasculature development; ISO:RGD.
DR   InterPro; IPR010796; C2_B9-type_dom.
DR   PANTHER; PTHR12968; PTHR12968; 1.
DR   Pfam; PF07162; B9-C2; 1.
DR   PROSITE; PS51381; C2_B9; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..204
FT                   /note="B9 domain-containing protein 1"
FT                   /id="PRO_0000307669"
FT   DOMAIN          9..127
FT                   /note="C2 B9-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00713"
SQ   SEQUENCE   204 AA;  22655 MW;  144D2EA35B002C58 CRC64;
     MAAASPSVFL LMVNGQVESA QFPEYDDLYC KYCFVYGQDW APTAGLEEGI SQIASKSQDV
     RQALVWNFPI DVTFKSTNPY GWPQIVLSVY GPDVFGNDVV RGYGAVHVPF SPGRHKRTIP
     MFVPESTSTL QKFTSWFMGR RPEYTDPKVV AQGEGREVTR VRSQGFVTLL FNVVTKDMKK
     LGYDTGPVDT QGVLSPSLPQ GNPQ