ID   B9D1_XENLA              Reviewed;         198 AA.
AC   Q6DFD7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=B9 domain-containing protein 1;
GN   Name=b9d1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the tectonic-like complex, a complex localized
CC       at the transition zone of primary cilia and acting as a barrier that
CC       prevents diffusion of transmembrane proteins between the cilia and
CC       plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH
CC       signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Note=Localizes at the transition zone, a region between
CC       the basal body and the ciliary axoneme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the B9D family. {ECO:0000305}.
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DR   EMBL; BC076802; AAH76802.1; -; mRNA.
DR   RefSeq; NP_001086557.1; NM_001093088.1.
DR   AlphaFoldDB; Q6DFD7; -.
DR   DNASU; 446392; -.
DR   GeneID; 446392; -.
DR   KEGG; xla:446392; -.
DR   CTD; 446392; -.
DR   Xenbase; XB-GENE-6251476; b9d1.L.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 446392; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR010796; C2_B9-type_dom.
DR   PANTHER; PTHR12968; PTHR12968; 1.
DR   Pfam; PF07162; B9-C2; 1.
DR   PROSITE; PS51381; C2_B9; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..198
FT                   /note="B9 domain-containing protein 1"
FT                   /id="PRO_0000307671"
FT   DOMAIN          8..126
FT                   /note="C2 B9-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00713"
SQ   SEQUENCE   198 AA;  22001 MW;  63297255AC8CC931 CRC64;
     MASGPSVFLL NVSGQIESAE FPEFDDLYCK YSFVYGHDWA PTSGIEEGIS QITSKSQGGK
     QTLVWNFPVE ITFKSTNPYG WPQIVISVYG PDVFGNDVVR GYGAVHLPFT PGRHTRTIPM
     FVPESSSRLQ RFTSWFMGRR PEFTDPKVVA QGEGREVTRV RSQGCVTVSF NVVTKDLKKL
     GYNTGSSDFP SAQLMPQP