ID   B9D1_XENTR              Reviewed;         198 AA.
AC   Q5BJ61;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=B9 domain-containing protein 1;
GN   Name=b9d1; ORFNames=TGas061g21.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the tectonic-like complex, a complex localized
CC       at the transition zone of primary cilia and acting as a barrier that
CC       prevents diffusion of transmembrane proteins between the cilia and
CC       plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH
CC       signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Note=Localizes at the transition zone, a region between
CC       the basal body and the ciliary axoneme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the B9D family. {ECO:0000305}.
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DR   EMBL; CR761492; CAJ83871.1; -; mRNA.
DR   EMBL; BC091609; AAH91609.1; -; mRNA.
DR   RefSeq; NP_001016309.1; NM_001016309.2.
DR   AlphaFoldDB; Q5BJ61; -.
DR   STRING; 8364.ENSXETP00000059625; -.
DR   PaxDb; Q5BJ61; -.
DR   DNASU; 549063; -.
DR   GeneID; 549063; -.
DR   KEGG; xtr:549063; -.
DR   CTD; 27077; -.
DR   Xenbase; XB-GENE-971084; b9d1.
DR   eggNOG; KOG4027; Eukaryota.
DR   HOGENOM; CLU_084934_0_0_1; -.
DR   InParanoid; Q5BJ61; -.
DR   OrthoDB; 1387644at2759; -.
DR   PhylomeDB; Q5BJ61; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR010796; C2_B9-type_dom.
DR   PANTHER; PTHR12968; PTHR12968; 1.
DR   Pfam; PF07162; B9-C2; 1.
DR   PROSITE; PS51381; C2_B9; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..198
FT                   /note="B9 domain-containing protein 1"
FT                   /id="PRO_0000307672"
FT   DOMAIN          8..126
FT                   /note="C2 B9-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00713"
SQ   SEQUENCE   198 AA;  21845 MW;  6C0C8B7EB7C02A8E CRC64;
     MASGPSVFLL NVSGQIESAE FPEFDDLYCK YSFVYGHDWA PTSGVEEGIS QITSKSQGGK
     QALVWNFPIE ITFKSTNPFG WPQIVISVYG PDAFGNDVVR GYGAVHLPFT PGRHARTIPM
     FVPESSSRLQ RFTSWFMGRR PEFTDPKVVA QGEGREVTRV RSQGCVTVSF NVVTKDLKKL
     GYNTGSGDFP NATTMSQP