ID   B9D2_DANRE              Reviewed;         175 AA.
AC   Q6DGZ1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=B9 domain-containing protein 2;
GN   Name=b9d2; ORFNames=zgc:92713;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the tectonic-like complex, a complex localized
CC       at the transition zone of primary cilia and acting as a barrier that
CC       prevents diffusion of transmembrane proteins between the cilia and
CC       plasma membranes. {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the B9D family. {ECO:0000305}.
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DR   EMBL; BC076193; AAH76193.1; -; mRNA.
DR   RefSeq; NP_001002394.1; NM_001002394.1.
DR   RefSeq; XP_005161219.1; XM_005161162.3.
DR   AlphaFoldDB; Q6DGZ1; -.
DR   STRING; 7955.ENSDARP00000007567; -.
DR   PaxDb; Q6DGZ1; -.
DR   Ensembl; ENSDART00000008099; ENSDARP00000007567; ENSDARG00000017385.
DR   Ensembl; ENSDART00000189148; ENSDARP00000153034; ENSDARG00000017385.
DR   GeneID; 436667; -.
DR   KEGG; dre:436667; -.
DR   CTD; 80776; -.
DR   ZFIN; ZDB-GENE-040718-90; b9d2.
DR   eggNOG; KOG4028; Eukaryota.
DR   GeneTree; ENSGT00940000161428; -.
DR   HOGENOM; CLU_084934_2_1_1; -.
DR   InParanoid; Q6DGZ1; -.
DR   OMA; IMRHFDK; -.
DR   OrthoDB; 367491at2759; -.
DR   PhylomeDB; Q6DGZ1; -.
DR   TreeFam; TF314883; -.
DR   Reactome; R-DRE-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-DRE-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-DRE-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-DRE-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q6DGZ1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000017385; Expressed in mature ovarian follicle and 20 other tissues.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; IDA:ZFIN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0043015; F:gamma-tubulin binding; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; IMP:CACAO.
DR   GO; GO:0001736; P:establishment of planar polarity; IGI:ZFIN.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IMP:CACAO.
DR   GO; GO:0036372; P:opsin transport; IMP:CACAO.
DR   InterPro; IPR010796; C2_B9-type_dom.
DR   PANTHER; PTHR12968; PTHR12968; 1.
DR   Pfam; PF07162; B9-C2; 1.
DR   PROSITE; PS51381; C2_B9; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN           1..175
FT                   /note="B9 domain-containing protein 2"
FT                   /id="PRO_0000307677"
FT   DOMAIN          2..118
FT                   /note="C2 B9-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00713"
SQ   SEQUENCE   175 AA;  19823 MW;  BC793D551CC5BEB9 CRC64;
     MAELHIIGQI IGATGFPQNS LFCKWGVHTG GAWRLLSGLR EGQTQVDMPQ TGDMAYWSHP
     IDLHYTTKGL QGWPKLHLQV WHQDSFGRCQ LYGYGYIHVP SSPGQHRLQC VTWRPLGSWQ
     DQLSEMFVGG GPQLRSPDLI YSGADRYRLH TVGMGTVELE LCIILRHFDR YGVES