ID   B9D2_RAT                Reviewed;         175 AA.
AC   P0C5J3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=B9 domain-containing protein 2;
GN   Name=B9d2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   Lee N.H., Glodek A., Chandra I., Mason T.M., Quackenbush J.,
RA   Kerlavage A.R., Adams M.D.;
RT   "Rat genome project: generation of a rat EST (REST) catalog & rat gene
RT   index.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the tectonic-like complex, a complex localized
CC       at the transition zone of primary cilia and acting as a barrier that
CC       prevents diffusion of transmembrane proteins between the cilia and
CC       plasma membranes. {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       Interacts with TUBG1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.
CC       Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the B9D family. {ECO:0000305}.
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DR   EMBL; AI227900; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001100964.1; NM_001107494.1.
DR   RefSeq; XP_006228500.1; XM_006228438.3.
DR   AlphaFoldDB; P0C5J3; -.
DR   STRING; 10116.ENSRNOP00000028029; -.
DR   PaxDb; P0C5J3; -.
DR   Ensembl; ENSRNOT00000028029; ENSRNOP00000028029; ENSRNOG00000028753.
DR   GeneID; 308443; -.
DR   KEGG; rno:308443; -.
DR   UCSC; RGD:1566122; rat.
DR   CTD; 80776; -.
DR   RGD; 1566122; B9d2.
DR   eggNOG; KOG4028; Eukaryota.
DR   GeneTree; ENSGT00940000161428; -.
DR   HOGENOM; CLU_084934_2_1_1; -.
DR   InParanoid; P0C5J3; -.
DR   OMA; IMRHFDK; -.
DR   OrthoDB; 367491at2759; -.
DR   PhylomeDB; P0C5J3; -.
DR   Reactome; R-RNO-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-RNO-2467813; Separation of Sister Chromatids.
DR   Reactome; R-RNO-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-RNO-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-RNO-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-RNO-68877; Mitotic Prometaphase.
DR   Reactome; R-RNO-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:P0C5J3; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000028753; Expressed in frontal cortex and 19 other tissues.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043015; F:gamma-tubulin binding; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR010796; C2_B9-type_dom.
DR   PANTHER; PTHR12968; PTHR12968; 1.
DR   Pfam; PF07162; B9-C2; 1.
DR   PROSITE; PS51381; C2_B9; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..175
FT                   /note="B9 domain-containing protein 2"
FT                   /id="PRO_0000307676"
FT   DOMAIN          2..118
FT                   /note="C2 B9-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00713"
SQ   SEQUENCE   175 AA;  19208 MW;  82AF5748A70DFE50 CRC64;
     MAEVHVIGQI IGATGFSEGS LFCKWGIHTG AAWKLLSGVR EGQTQVDTPQ TGDMAYWSHP
     IDLHFATKGL QGWPRLHLQV WSQDSFGRCQ LAGYGFCHVP SSPGTHQLDC PTWRPLGSWR
     EQLARAFVGG GPQLLHADTI YSGADRYRLH TAAGGTVHLG IGLLLRHFDR YGVEC