BAALC_MOUSE
ID BAALC_MOUSE Reviewed; 145 AA.
AC Q8VHV1; A9JR49; Q8VBS8; Q9CYS9;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Brain and acute leukemia cytoplasmic protein;
GN Name=Baalc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC STRAIN=129S6/SvEvTac;
RX PubMed=11707601; DOI=10.1073/pnas.241525498;
RA Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K.,
RA Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A.,
RA Bloomfield C.D., de La Chapelle A.;
RT "BAALC, the human member of a novel mammalian neuroectoderm gene lineage,
RT is implicated in hematopoiesis and acute leukemia.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15749074; DOI=10.1016/j.modgep.2004.12.008;
RA Satoskar A.A., Tanner S.M., Weinstein M., Qualman S.J., de la Chapelle A.;
RT "Baalc, a marker of mesoderm and muscle.";
RL Gene Expr. Patterns 5:463-473(2005).
CC -!- FUNCTION: May play a synaptic role at the postsynaptic lipid rafts
CC possibly through interaction with CAMK2A.
CC {ECO:0000250|UniProtKB:Q920K5}.
CC -!- SUBUNIT: Interacts with CAMK2A. {ECO:0000250|UniProtKB:Q920K5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15749074}. Synapse,
CC synaptosome {ECO:0000250|UniProtKB:Q920K5}. Membrane raft
CC {ECO:0000250|UniProtKB:Q920K5}. Postsynaptic density
CC {ECO:0000250|UniProtKB:Q920K5}. Note=In neurons, localizes to
CC postsynaptic lipid rafts (By similarity). In myocardial and skeletal
CC muscle cells, localizes to the cytoplasm adjacent to the inner cell
CC membrane, polarized to one end of the myocyte (PubMed:15749074).
CC {ECO:0000250|UniProtKB:Q920K5, ECO:0000269|PubMed:15749074}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=1-6-8;
CC IsoId=Q8VHV1-1; Sequence=Displayed;
CC Name=2; Synonyms=1-8;
CC IsoId=Q8VHV1-2; Sequence=VSP_020206;
CC Name=3;
CC IsoId=Q8VHV1-3; Sequence=VSP_020205;
CC -!- TISSUE SPECIFICITY: At the mRNA level, predominantly expressed in the
CC brain (PubMed:11707601). At the protein level, mainly expressed in
CC muscle tissues. In skeletal muscles, expressed in cranial and facial
CC muscles, muscles of the neck, back, thoracic wall, and thigh. Also
CC found in the contractile myoepithelial cell layer of salivary glands.
CC In smooth muscles, expressed in the gastric wall, uterus, urinary
CC bladder, as well as in the muscular lining around seminiferous tubules,
CC prostatic ducts, epididymis, vas deferens, walls of small blood vessels
CC in the dermis, and fascial layers between muscle fibers, brain, and
CC around the spinal cord. Strongly expressed in myocardium. High
CC expression levels are observed in placental spongiotrophoblast and
CC adjacent myometrium. Also expressed in bone marrow hematopoietic cells.
CC In the mature thymus, expressed in rare scattered cells. Weakly
CC expressed in the brain neuropil, particularly near the hippocampus, and
CC spinal cord white matter. Not detected in skin keratinocytes or lung
CC (at protein level) (PubMed:15749074). {ECO:0000269|PubMed:11707601,
CC ECO:0000269|PubMed:15749074}.
CC -!- DEVELOPMENTAL STAGE: During embryonic development, prominently
CC expressed in muscle tissues, including myocardium, skeletal and smooth
CC muscles, and weakly in the developing central nervous system (only in
CC the neuropil). At 9 dpc, expressed in the wall and trabeculae of the
CC developing heart tube, in the caudal end of the midline dorsal aorta,
CC and a focal area of the mesenchyme around the developing brain. Weakly
CC expressed in marginal and ependymal layers of the early neural tube. At
CC 11-12.5 dpc, expression persists in the myocardium. Scattered signal in
CC the mesoderm on either side of the developing neural tube. Also found
CC in the region of dermatomyotomes. Appears to be associated with the
CC early pre-muscle mesoderm and later with myoblasts and myocytes of the
CC paravertebral, back, body wall and limb muscles. At 13-15 dpc, besides
CC the myocardium, expression is seen in the skeletal muscles of the
CC limbs, intercostal muscles, and the diaphragm, as well as in the
CC developing muscle layer in the wall of the few intestinal coils present
CC in the abdominal cavity. Also found in various components of the
CC mesenchymal precartilage forming the framework of the cranium and the
CC face, notably, the base of the skull, frontonasal process and parts of
CC the primitive maxillary and mandibular processes. Around 13 dpc,
CC detected in the brain lateral ventricles and the roof of the fourth
CC ventricle. At 15 dpc, scattered groups of positive cells are observed
CC in the liver, around the venous sinuses. Weakly expressed in the brain
CC and spinal cord white matter. Prominent membrane expression in the
CC choroid plexus and meninges. At 15-18 dpc, transiently expressed in the
CC layers of ectodermal cells covering the embryo and in immature cells of
CC the lung buds. From 16 dpc to postnatal day 2, no change in the basic
CC pattern of expression (at protein level).
CC {ECO:0000269|PubMed:15749074}.
CC -!- PTM: Palmitoylation and myristoylation target the protein to the lipid
CC rafts. {ECO:0000250|UniProtKB:Q920K5}.
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DR EMBL; AF371320; AAL50516.1; -; mRNA.
DR EMBL; AF371324; AAL50520.1; -; mRNA.
DR EMBL; AK013358; BAB28808.1; -; mRNA.
DR EMBL; AK079337; BAC37611.1; -; mRNA.
DR EMBL; BC150479; AAI50480.1; -; mRNA.
DR RefSeq; NP_542371.1; NM_080640.5. [Q8VHV1-1]
DR AlphaFoldDB; Q8VHV1; -.
DR STRING; 10090.ENSMUSP00000132788; -.
DR PhosphoSitePlus; Q8VHV1; -.
DR PaxDb; Q8VHV1; -.
DR PRIDE; Q8VHV1; -.
DR ProteomicsDB; 277099; -. [Q8VHV1-1]
DR ProteomicsDB; 277100; -. [Q8VHV1-2]
DR ProteomicsDB; 277101; -. [Q8VHV1-3]
DR Antibodypedia; 26359; 151 antibodies from 30 providers.
DR DNASU; 118452; -.
DR Ensembl; ENSMUST00000163313; ENSMUSP00000132788; ENSMUSG00000022296. [Q8VHV1-3]
DR Ensembl; ENSMUST00000226440; ENSMUSP00000154447; ENSMUSG00000022296. [Q8VHV1-1]
DR Ensembl; ENSMUST00000239553; ENSMUSP00000159442; ENSMUSG00000022296. [Q8VHV1-2]
DR GeneID; 118452; -.
DR KEGG; mmu:118452; -.
DR UCSC; uc007vnx.2; mouse. [Q8VHV1-1]
DR CTD; 79870; -.
DR MGI; MGI:1928704; Baalc.
DR VEuPathDB; HostDB:ENSMUSG00000022296; -.
DR eggNOG; KOG4119; Eukaryota.
DR GeneTree; ENSGT00390000013853; -.
DR HOGENOM; CLU_164139_0_0_1; -.
DR InParanoid; Q8VHV1; -.
DR OMA; PQQDKMS; -.
DR OrthoDB; 1437892at2759; -.
DR PhylomeDB; Q8VHV1; -.
DR TreeFam; TF330767; -.
DR BioGRID-ORCS; 118452; 0 hits in 50 CRISPR screens.
DR PRO; PR:Q8VHV1; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8VHV1; protein.
DR Bgee; ENSMUSG00000022296; Expressed in frontal cortex and 39 other tissues.
DR ExpressionAtlas; Q8VHV1; baseline and differential.
DR Genevisible; Q8VHV1; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0016528; C:sarcoplasm; IDA:MGI.
DR InterPro; IPR009728; BAALC.
DR PANTHER; PTHR14731; PTHR14731; 1.
DR Pfam; PF06989; BAALC_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Lipoprotein; Membrane; Myristate;
KW Palmitate; Reference proteome; Synapse; Synaptosome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q920K5"
FT CHAIN 2..145
FT /note="Brain and acute leukemia cytoplasmic protein"
FT /id="PRO_0000248206"
FT REGION 3..35
FT /note="Interaction with CAMK2A"
FT /evidence="ECO:0000250|UniProtKB:Q920K5"
FT REGION 36..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250|UniProtKB:Q920K5"
FT LIPID 3
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q920K5"
FT VAR_SEQ 1..53
FT /note="MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDALPSAAATDSGPEAGGLH
FT A -> MPVTPVASGWLLSAHLADPFFDPWAFFSYKS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020205"
FT VAR_SEQ 55..145
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11707601,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_020206"
SQ SEQUENCE 145 AA; 15515 MW; 4972670A618C4D6D CRC64;
MGCGGSRADA IEPRYYESWT RETESTWLTY TDSDALPSAA ATDSGPEAGG LHAGVLEDGL
SSNGVLRPAA PGGIANPEKK MNCGTQCPNS QNLSSGPLTQ KQNGLWATEA KRDAKRMSAR
EVAINVTENI RQMDRSKRVT KNCIN
