BAALC_PIG
ID BAALC_PIG Reviewed; 145 AA.
AC Q8WNE9; Q8WNE8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Brain and acute leukemia cytoplasmic protein;
GN Name=BAALC;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RX PubMed=11707601; DOI=10.1073/pnas.241525498;
RA Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K.,
RA Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A.,
RA Bloomfield C.D., de La Chapelle A.;
RT "BAALC, the human member of a novel mammalian neuroectoderm gene lineage,
RT is implicated in hematopoiesis and acute leukemia.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001).
CC -!- FUNCTION: May play a synaptic role at the postsynaptic lipid rafts
CC possibly through interaction with CAMK2A.
CC {ECO:0000250|UniProtKB:Q920K5}.
CC -!- SUBUNIT: Interacts with CAMK2A. {ECO:0000250|UniProtKB:Q920K5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8VHV1}.
CC Synapse, synaptosome {ECO:0000250|UniProtKB:Q920K5}. Membrane raft
CC {ECO:0000250|UniProtKB:Q920K5}. Postsynaptic density
CC {ECO:0000250|UniProtKB:Q920K5}. Note=In neurons, localizes to
CC postsynaptic lipid rafts (By similarity). In myocardial and skeletal
CC muscle cells, localizes to the cytoplasm adjacent to the inner cell
CC membrane, polarized to one end of the myocyte (By similarity).
CC {ECO:0000250|UniProtKB:Q8VHV1, ECO:0000250|UniProtKB:Q920K5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=1-6-8;
CC IsoId=Q8WNE9-1; Sequence=Displayed;
CC Name=2; Synonyms=1-8;
CC IsoId=Q8WNE9-2; Sequence=VSP_020207;
CC -!- TISSUE SPECIFICITY: Expressed in the brain.
CC {ECO:0000269|PubMed:11707601}.
CC -!- PTM: Palmitoylation and myristoylation target the protein to the lipid
CC rafts. {ECO:0000250|UniProtKB:Q920K5}.
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DR EMBL; AF371322; AAL50518.1; -; mRNA.
DR EMBL; AF371326; AAL50522.1; -; mRNA.
DR RefSeq; NP_001123441.1; NM_001129969.1. [Q8WNE9-1]
DR RefSeq; XP_013852016.1; XM_013996562.1.
DR AlphaFoldDB; Q8WNE9; -.
DR STRING; 9823.ENSSSCP00000006463; -.
DR PaxDb; Q8WNE9; -.
DR PRIDE; Q8WNE9; -.
DR Ensembl; ENSSSCT00025084170; ENSSSCP00025036622; ENSSSCG00025061420. [Q8WNE9-1]
DR Ensembl; ENSSSCT00045041696; ENSSSCP00045028924; ENSSSCG00045024476. [Q8WNE9-1]
DR Ensembl; ENSSSCT00050071788; ENSSSCP00050030875; ENSSSCG00050052707. [Q8WNE9-1]
DR Ensembl; ENSSSCT00055001283; ENSSSCP00055000950; ENSSSCG00055000736. [Q8WNE9-1]
DR GeneID; 100170128; -.
DR KEGG; ssc:100170128; -.
DR CTD; 79870; -.
DR eggNOG; KOG4119; Eukaryota.
DR HOGENOM; CLU_201318_0_0_1; -.
DR InParanoid; Q8WNE9; -.
DR OrthoDB; 1437892at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR InterPro; IPR009728; BAALC.
DR PANTHER; PTHR14731; PTHR14731; 1.
DR Pfam; PF06989; BAALC_N; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Lipoprotein; Membrane; Myristate;
KW Palmitate; Reference proteome; Synapse; Synaptosome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q920K5"
FT CHAIN 2..145
FT /note="Brain and acute leukemia cytoplasmic protein"
FT /id="PRO_0000248207"
FT REGION 3..35
FT /note="Interaction with CAMK2A"
FT /evidence="ECO:0000250|UniProtKB:Q920K5"
FT REGION 27..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250|UniProtKB:Q920K5"
FT LIPID 3
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q920K5"
FT VAR_SEQ 54..144
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11707601"
FT /id="VSP_020207"
SQ SEQUENCE 145 AA; 15401 MW; C75ED7D00EF82E26 CRC64;
MGCGGSRADA IEPRYYESWT RETESTWLTY TDSDAPPSNA APDSGPEAGG LQAGVLEDGV
SANGVPRSTA PGGTSNPEKK MSCGTQCPNP QSLGSGPLTQ KQNGLRTTEA KRDAKRTSAK
EVTINVTESI RQVDRNQRIT KKCIN
