BAALC_RAT
ID BAALC_RAT Reviewed; 145 AA.
AC Q920K5; Q790N3;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Brain and acute leukemia cytoplasmic protein;
GN Name=Baalc;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley;
RX PubMed=11707601; DOI=10.1073/pnas.241525498;
RA Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K.,
RA Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A.,
RA Bloomfield C.D., de La Chapelle A.;
RT "BAALC, the human member of a novel mammalian neuroectoderm gene lineage,
RT is implicated in hematopoiesis and acute leukemia.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CAMK2A,
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP MYRISTOYLATION AT GLY-2, PALMITOYLATION AT CYS-3, AND MUTAGENESIS OF GLY-2
RP AND CYS-3.
RX PubMed=15659234; DOI=10.1111/j.1471-4159.2004.02902.x;
RA Wang X., Tian Q.-B., Okano A., Sakagami H., Moon I.S., Kondo H., Endo S.,
RA Suzuki T.;
RT "BAALC 1-6-8 protein is targeted to postsynaptic lipid rafts by its N-
RT terminal myristoylation and palmitoylation, and interacts with a, but not
RT b, subunit of Ca2+/calmodulin-dependent protein kinase II.";
RL J. Neurochem. 92:647-659(2005).
CC -!- FUNCTION: May play a synaptic role at the postsynaptic lipid rafts
CC possibly through interaction with CAMK2A.
CC {ECO:0000303|PubMed:15659234}.
CC -!- SUBUNIT: Interacts with CAMK2A. {ECO:0000269|PubMed:15659234}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8VHV1}.
CC Synapse, synaptosome {ECO:0000269|PubMed:15659234}. Membrane raft
CC {ECO:0000269|PubMed:15659234}. Postsynaptic density
CC {ECO:0000269|PubMed:15659234}. Note=In neurons, localizes to
CC postsynaptic lipid rafts (PubMed:15659234). In myocardial and skeletal
CC muscle cells, localizes to the cytoplasm adjacent to the inner cell
CC membrane, polarized to one end of the myocyte (By similarity).
CC {ECO:0000250|UniProtKB:Q8VHV1, ECO:0000269|PubMed:15659234}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=1-6-8;
CC IsoId=Q920K5-1; Sequence=Displayed;
CC Name=2; Synonyms=1-8;
CC IsoId=Q920K5-2; Sequence=VSP_020208;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in the brain (at protein
CC level) (PubMed:11707601, PubMed:15659234). Within the brain, found in
CC most of forebrain structures, including the cerebral cortex,
CC hippocampal formation, olfactory bulb, anterior olfactory nuclei,
CC piriform cortex, tenia tecta and amygdaloid nuclei. Not detected in
CC glial cells (PubMed:15659234). {ECO:0000269|PubMed:11707601,
CC ECO:0000269|PubMed:15659234}.
CC -!- DEVELOPMENTAL STAGE: In the developing forebrain, barely detected at
CC postnatal day 1. Expression increases from the first week after birth.
CC High levels are reached during 2 and 3 weeks after birth and slightly
CC decrease at 6 weeks after birth. This expression pattern parallels
CC synaptogenesis. {ECO:0000269|PubMed:15659234}.
CC -!- PTM: Palmitoylation and myristoylation target the protein to the lipid
CC rafts. {ECO:0000269|PubMed:15659234}.
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DR EMBL; AF371321; AAL50517.1; -; mRNA.
DR EMBL; AF371325; AAL50521.1; -; mRNA.
DR EMBL; AB073318; BAB70507.1; -; mRNA.
DR RefSeq; NP_658907.1; NM_144762.2. [Q920K5-1]
DR AlphaFoldDB; Q920K5; -.
DR STRING; 10116.ENSRNOP00000006411; -.
DR iPTMnet; Q920K5; -.
DR SwissPalm; Q920K5; -.
DR PaxDb; Q920K5; -.
DR Ensembl; ENSRNOT00000006411; ENSRNOP00000006411; ENSRNOG00000004697. [Q920K5-1]
DR GeneID; 140720; -.
DR KEGG; rno:140720; -.
DR UCSC; RGD:628703; rat. [Q920K5-1]
DR CTD; 79870; -.
DR RGD; 628703; Baalc.
DR eggNOG; KOG4119; Eukaryota.
DR GeneTree; ENSGT00390000013853; -.
DR HOGENOM; CLU_135096_0_0_1; -.
DR InParanoid; Q920K5; -.
DR OMA; PQQDKMS; -.
DR OrthoDB; 1437892at2759; -.
DR PhylomeDB; Q920K5; -.
DR TreeFam; TF330767; -.
DR PRO; PR:Q920K5; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000004697; Expressed in Ammon's horn and 10 other tissues.
DR Genevisible; Q920K5; RN.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0016528; C:sarcoplasm; IEA:Ensembl.
DR InterPro; IPR009728; BAALC.
DR PANTHER; PTHR14731; PTHR14731; 1.
DR Pfam; PF06989; BAALC_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Lipoprotein; Membrane; Myristate;
KW Palmitate; Reference proteome; Synapse; Synaptosome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000305|PubMed:15659234"
FT CHAIN 2..145
FT /note="Brain and acute leukemia cytoplasmic protein"
FT /id="PRO_0000248208"
FT REGION 3..35
FT /note="Interaction with CAMK2A"
FT /evidence="ECO:0000269|PubMed:15659234"
FT REGION 36..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:15659234"
FT LIPID 3
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000269|PubMed:15659234"
FT VAR_SEQ 55..145
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11707601"
FT /id="VSP_020208"
FT MUTAGEN 2
FT /note="G->A: Abolishes myristoylation."
FT /evidence="ECO:0000269|PubMed:15659234"
FT MUTAGEN 3
FT /note="C->A: Abolishes palmitoylation."
FT /evidence="ECO:0000269|PubMed:15659234"
SQ SEQUENCE 145 AA; 15475 MW; D5A27AD67456F341 CRC64;
MGCGGSRADA IEPRYYESWT RETESTWLTY TDSDALPSAA ATDSGPEAGG LHAGVLEDGP
SSNGVLRPAA PGGIANPEKK MNCGTQCPNS QSLSSGPLTQ KQNGLWTTEA KRDAKRMSAR
EVAISVTENI RQMDRSKRVT KNCIN
