BAB1_DROME
ID BAB1_DROME Reviewed; 977 AA.
AC Q9W0K7; Q23968; Q8MR78; Q9U1H7;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Protein bric-a-brac 1;
GN Name=bab1; Synonyms=bab; ORFNames=CG9097;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAF47439.2};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Larva, and Ovary;
RX PubMed=11973274; DOI=10.1242/dev.129.10.2419;
RA Couderc J.-L.G., Godt D., Zollman S., Chen J., Li M., Tiong S.,
RA Cramton S.E., Sahut-Barnola I., Laski F.A.;
RT "The bric a brac locus consists of two paralogous genes encoding BTB/POZ
RT domain proteins and acts as a homeotic and morphogenetic regulator of
RT imaginal development in Drosophila.";
RL Development 129:2419-2433(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-512.
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305}
RP RETRACTED PAPER.
RX PubMed=7760839; DOI=10.1128/mcb.15.6.3424;
RA Chen W., Zollman S., Couderc J.-L., Laski F.A.;
RT "The BTB domain of bric a brac mediates dimerization in vitro.";
RL Mol. Cell. Biol. 15:3424-3429(1995).
RN [6]
RP RETRACTION NOTICE OF PUBMED:7760839.
RX PubMed=9380040; DOI=10.1128/mcb.17.11.6772;
RA Chen W., Zollman S., Couderc J.L., Laski F.A.;
RT "Retraction. The BTB domain of bric a brac mediates dimerization in
RT vitro.";
RL Mol. Cell. Biol. 17:6772-6772(1997).
CC -!- FUNCTION: Probably acts as a transcriptional regulator. Required for
CC the specification of the tarsal segment. Also involved in antenna
CC development. {ECO:0000269|PubMed:11973274,
CC ECO:0000303|PubMed:11973274}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC ECO:0000269|PubMed:11973274}.
CC -!- TISSUE SPECIFICITY: Leg imaginal disk at the central region of the
CC tarsus and in eye antenna disk at the basal cylinder.
CC {ECO:0000269|PubMed:11973274}.
CC -!- MISCELLANEOUS: 'Bric-a-brac' means 'jumble' in French (referring to the
CC mutant ovary phenotype).
CC -!- CAUTION: A paper showing that the protein forms homodimers via the BTB
CC domain has been retracted by the authors, due to concerns regarding the
CC validity of their data. However, they still consider that their main
CC conclusions may be correct and require further testing.
CC {ECO:0000305|PubMed:7760839}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM52587.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ252082; CAB64385.1; -; mRNA.
DR EMBL; AE014296; AAF47439.2; -; Genomic_DNA.
DR EMBL; AY122075; AAM52587.1; ALT_SEQ; mRNA.
DR EMBL; U01333; AAA87052.1; -; Genomic_DNA.
DR RefSeq; NP_728565.1; NM_167852.2.
DR AlphaFoldDB; Q9W0K7; -.
DR SMR; Q9W0K7; -.
DR BioGRID; 63665; 13.
DR DIP; DIP-18590N; -.
DR IntAct; Q9W0K7; 9.
DR STRING; 7227.FBpp0072538; -.
DR PaxDb; Q9W0K7; -.
DR EnsemblMetazoa; FBtr0072642; FBpp0072538; FBgn0004870.
DR GeneID; 38116; -.
DR KEGG; dme:Dmel_CG9097; -.
DR CTD; 38116; -.
DR FlyBase; FBgn0004870; bab1.
DR VEuPathDB; VectorBase:FBgn0004870; -.
DR eggNOG; ENOG502RYZ4; Eukaryota.
DR GeneTree; ENSGT00940000173981; -.
DR InParanoid; Q9W0K7; -.
DR OMA; NDRSETE; -.
DR OrthoDB; 686400at2759; -.
DR PhylomeDB; Q9W0K7; -.
DR SignaLink; Q9W0K7; -.
DR BioGRID-ORCS; 38116; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38116; -.
DR PRO; PR:Q9W0K7; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0004870; Expressed in ventral thoracic disc and 9 other tissues.
DR ExpressionAtlas; Q9W0K7; baseline and differential.
DR Genevisible; Q9W0K7; DM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:FlyBase.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IDA:FlyBase.
DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IEP:UniProtKB.
DR GO; GO:0046660; P:female sex differentiation; TAS:FlyBase.
DR GO; GO:0007478; P:leg disc morphogenesis; IEP:UniProtKB.
DR GO; GO:0048086; P:negative regulation of developmental pigmentation; TAS:FlyBase.
DR GO; GO:0048092; P:negative regulation of male pigmentation; NAS:FlyBase.
DR GO; GO:0048070; P:regulation of developmental pigmentation; TAS:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:UniProtKB.
DR GO; GO:0007548; P:sex differentiation; IMP:FlyBase.
DR GO; GO:0048071; P:sex-specific pigmentation; TAS:FlyBase.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF05225; HTH_psq; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..977
FT /note="Protein bric-a-brac 1"
FT /id="PRO_0000064790"
FT DOMAIN 127..192
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037,
FT ECO:0000305"
FT DOMAIN 559..611
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 569..614
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 621..632
FT /note="A.T hook"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 66
FT /note="K -> R (in Ref. 1; CAB64385)"
FT /evidence="ECO:0000305"
FT CONFLICT 188..189
FT /note="IN -> VS (in Ref. 1; CAB64385)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="A -> R (in Ref. 1; CAB64385 and 4; AAM52587)"
FT /evidence="ECO:0000305"
FT CONFLICT 257
FT /note="A -> G (in Ref. 1; CAB64385)"
FT /evidence="ECO:0000305"
FT CONFLICT 264..265
FT /note="KL -> NV (in Ref. 1; CAB64385)"
FT /evidence="ECO:0000305"
FT CONFLICT 283..284
FT /note="QQ -> HE (in Ref. 1; CAB64385)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="D -> E (in Ref. 1; CAB64385)"
FT /evidence="ECO:0000305"
FT CONFLICT 444
FT /note="R -> M (in Ref. 1; CAB64385 and 4; AAM52587)"
FT /evidence="ECO:0000305"
FT CONFLICT 763
FT /note="N -> S (in Ref. 1; CAB64385)"
FT /evidence="ECO:0000305"
FT CONFLICT 846
FT /note="Q -> QQQ (in Ref. 1; CAB64385)"
FT /evidence="ECO:0000305"
FT CONFLICT 862
FT /note="A -> V (in Ref. 1; CAB64385)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 977 AA; 103324 MW; A7676B72A43126C5 CRC64;
MASAQAETNV GLASEQGPVA QRQRKGTGSG ADSPKSNRSS PTQQEEKRIK SEDRTSPTGG
AKDEDKESQG HAVAGGGGSS PVSSPQGRSS SVASPSSSSQ QFCLRWNNYQ TNLTTIFDQL
LQNECFVDVT LACDGRSMKA HKMVLSACSP YFQTLLAETP CQHPIVIMRD VNWSDLKAIV
EFMYRGEINV SQDQIGPLLR IAEMLKVRGL ADVTHMEAAT AAAAAASSER MPSSPKESTS
TSRTEHDRER EAEELLAFMQ PEKKLRTSDW DPAELRLSPL ERQQGRNVRK RRWPSADTIF
NPPAPPSPLS SLIAAERMEL EQKERERQRD CSLMTPPPKP PMSSGSTVGA TRRLETAIHA
LDMPSPAATP GPLSRSSRPH SQSPQQQQAQ QQGQLPLPLP LHPHHHASPA PHPSQTAGSA
HHPASPAGDS RFPLGPAAAM AAARELSGLG PGPSAEPRLP PPPPHHHGGG GVGGGGVGGG
GAGGVGSGGG SSLADDLEIK PGIAEMIREE ERAKMMENSH AWMGATGSTL AADSYQYQLQ
SMWQKCWNTN QNLMHHMRFR ERGPLKSWRP ETMAEAIFSV LKEGLSLSQA ARKYDIPYPT
FVLYANRVHN MLGPSIDGGP DLRPKGRGRP QRILLGIWPD EHIKGVIKTV VFRDTKDIKD
ESLAAHMPPY GRHSPAFPLQ DLPLSYPGAS GALAGAPSSM ACPNGSGPQT GVGVAGEQHM
SQETAAAVAA VAHNIRQQMQ MAAVPPGLFN LPPHPGVGGG VGNVPGAAGG RASISPALSS
GSGPRHAPSP CGPAGLLPNL PPSMAVALHH QQQQQAAHHH MQQLHLQQQQ AHLHHHQQQQ
QQQQQQHHQG GHQVAHKSGF GASSSSSASS SSMGQHHAPK AKSSPLRSET PRLHSPLGDL
GLDMASYKRE FSPSRLFAED LAELVGASVS SSSSSAAAAT APPERSAGAA SAATGADAPS
SSSSGGIKVE PITTTSE
