ID   RS21_DROPS              Reviewed;          83 AA.
AC   Q29KF5;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=40S ribosomal protein S21 {ECO:0000250|UniProtKB:O76927};
DE   AltName: Full=Overgrown hematopoietic organs at 23B {ECO:0000250|UniProtKB:O76927};
GN   Name=RpS21; Synonyms=oho23B; ORFNames=GA15559;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EAL33220.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: May be an associated component of the ribosome rather than a
CC       core structural subunit. May act as a translation initiation factor.
CC       Has a role in regulation of cell proliferation in the hematopoietic
CC       organs and the imaginal disks of larva (By similarity).
CC       {ECO:0000250|UniProtKB:O76927}.
CC   -!- SUBUNIT: Component of the 40S small ribosomal subunit. Interacts with
CC       sta. {ECO:0000250|UniProtKB:O76927}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P63220}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P63220}. Rough endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:P63221}. Note=Detected on cytosolic polysomes
CC       (By similarity). Detected in ribosomes that are associated with the
CC       rough endoplasmic reticulum (By similarity).
CC       {ECO:0000250|UniProtKB:P63220, ECO:0000250|UniProtKB:P63221}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS21 family.
CC       {ECO:0000255}.
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DR   EMBL; CH379061; EAL33220.2; -; Genomic_DNA.
DR   RefSeq; XP_001356160.2; XM_001356124.3.
DR   AlphaFoldDB; Q29KF5; -.
DR   SMR; Q29KF5; -.
DR   STRING; 7237.FBpp0287392; -.
DR   EnsemblMetazoa; FBtr0288954; FBpp0287392; FBgn0075576.
DR   GeneID; 4816681; -.
DR   KEGG; dpo:Dpse_GA15559; -.
DR   eggNOG; KOG3486; Eukaryota.
DR   HOGENOM; CLU_167122_2_0_1; -.
DR   InParanoid; Q29KF5; -.
DR   OMA; ALCGYIR; -.
DR   ChiTaRS; RpS21; fly.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0075576; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0022626; C:cytosolic ribosome; IEA:EnsemblMetazoa.
DR   GO; GO:0005840; C:ribosome; ISS:UniProtKB.
DR   GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:EnsemblMetazoa.
DR   GO; GO:0048542; P:lymph gland development; IEA:EnsemblMetazoa.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 3.30.1230.20; -; 1.
DR   InterPro; IPR001931; Ribosomal_S21e.
DR   InterPro; IPR018279; Ribosomal_S21e_CS.
DR   InterPro; IPR038579; Ribosomal_S21e_sf.
DR   PANTHER; PTHR10442; PTHR10442; 1.
DR   Pfam; PF01249; Ribosomal_S21e; 1.
DR   PIRSF; PIRSF002148; Ribosomal_S21e; 1.
DR   PROSITE; PS00996; RIBOSOMAL_S21E; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Endoplasmic reticulum;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein; rRNA processing;
KW   Translation regulation.
FT   CHAIN           1..83
FT                   /note="40S ribosomal protein S21"
FT                   /id="PRO_0000395421"
SQ   SEQUENCE   83 AA;  9167 MW;  DDFB9D498B396E05 CRC64;
     MENDAGENVD LYVPRKCSAS NRIIHAKDHA SVQLSIVDVD PETGRQTDGS KTYAICGEIR
     RMGESDDCIV RLAKKDGLIT KNF