ABCA3_DICDI
ID ABCA3_DICDI Reviewed; 1702 AA.
AC Q54BT5; Q8T6J4;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=ABC transporter A family member 3;
DE AltName: Full=ABC transporter ABCA.3;
GN Name=abcA3; ORFNames=DDB_G0293436;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000305}.
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DR EMBL; AF465305; AAL85296.1; -; Genomic_DNA.
DR EMBL; AAFI02000210; EAL60720.1; -; Genomic_DNA.
DR RefSeq; XP_629134.1; XM_629132.1.
DR AlphaFoldDB; Q54BT5; -.
DR SMR; Q54BT5; -.
DR STRING; 44689.DDB0201662; -.
DR PaxDb; Q54BT5; -.
DR PRIDE; Q54BT5; -.
DR EnsemblProtists; EAL60720; EAL60720; DDB_G0293436.
DR GeneID; 8629224; -.
DR KEGG; ddi:DDB_G0293436; -.
DR dictyBase; DDB_G0293436; abcA3.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; Q54BT5; -.
DR OMA; MDDLRYV; -.
DR PhylomeDB; Q54BT5; -.
DR Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR Reactome; R-DDI-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8963896; HDL assembly.
DR PRO; PR:Q54BT5; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1702
FT /note="ABC transporter A family member 3"
FT /id="PRO_0000363835"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 860..880
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 985..1005
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1026..1046
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1081..1101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1109..1129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1142..1162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1180..1200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1225..1245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 500..735
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1292..1527
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1257..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 536..543
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1330..1337
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 6
FT /note="F -> S (in Ref. 1; AAL85296)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1702 AA; 191800 MW; 1585990ACA7FE5F5 CRC64;
MGEFKFQLVT LLKKNSLLKG KSKIKFIGEI LAPMIVIGIL FGLLYLSAII QPDFSPRYAS
GFTEVVGRLK KLLVATNGPL VPYQQTIVNN LRKQIKLAHP DYTNEYIDQC FEIFQDFESM
QGYFLDPENY RGVMGGLWFD ENDYRYNAPK VLKYSISVDA DYTNDNNIQI SPRSDSQIYL
RHYFTQIQTA VDQAIFMAQN VEIPMVVTGQ RFPNPYIHLW QTWTDGRNMI LKETGGIFIT
AAIFVGLFTT ITNMVMEKES KILEAMKIMG LHSLPYYVSI AISSCYTIIP STIIVIVVLK
GSQLIWTTQW YILTIILILF SISLILLAFI LSKFFNRSKF AGLVCFLIVL IMAGIGIAVN
HINVSTTVKL IFCLLSPVAI SLANYSMSMK DLELVKIVNP DWSIIVSENQ VIGMLILDVV
LYAALVWYID NIISGEFGQS KPFYFFLTKS YWCKKNANEN DLVDLSKAIE SPLYLRKKDL
DYNNSQDFEL NEIHSSKATI QIRKLRKEFK TGDGKRVAVD DLSIDMYQDR IHCFLGPNGS
GKSTTIGMLT GLITCTRGSA LINGLDINQN IDLIRKNIGV VLQQDIIWDN LTVLEHLIFY
AQLKGYSNLK EAKTEAKKMG IEVGLELKLH NKAGTLSGGQ KRKLCLGIAF IGPNSNILFL
DEVSSGLDPL SRSEVQDFII SKKKGKTIIL STHYMDEADL LGDTISIIAH GKLKCNGSPL
FLKNRFGVGY LLTITKKSTE FNKDSVMEIT NKYIKQAHIL SDAGTELSIR LPMESLPMFS
QYFKHLEDCK NQLLIDSYGI SISTLEEVFL KIGQETLKST PNFNDPAVKE ALSTKSSGVK
VGQQLKGLLI KRICTTKKDF KSFMFSIVVP LIILALGLVM YKNMRTIETF NDVTTPLTFS
IDDYGDNIYV PWSISGQNQA IDLRIKNSIG KSNHSKLLPA DELEDYLTLN YEGNPGAFAF
GKTIIEDIEM LSFKVYYNRD YLHALPIYIN FVDNLMLSNL GGVGIQTTSR PFQHIKSKFE
LATEKINFSA IIFFIILTLA AFALVVASHA GNIAQERAAR IKRLLYISGL KKYVYWLSNL
IWDYVLTFIM VIFLAVVVVI IDSKFRNQFP LFICALVLFV TAIIPLSYLF SYCWSSHGKA
TGFIFGIHFG IGLLMTVTCF ILRIWVIKDD NDILQTITDI IDLVFFFFSP FYCFSKVMVI
ISNFPGTTRL GESYIANYWG IKFGLPPVCF LALHTLVWTI WIMVLDYYPE LRGKYRKGRN
EKSSPPPPSD EDSDVSHERS KVLSFETSND PIIMRDFFKL YKGKGKAKDN LAVYNTSLSI
PKGQTFGLLG LNGAGKSTTL GCLSGEVIPS GGEIFVNGFN IQTQRLDALR SVGFCHQYNS
LIGLLSAREQ IRLYCRIKGI EESKIQETVE AFIKMMDLGS IGNSNVAGYS GGNKRKVALS
VAIVGNPSVC FLDEVSAGVD PVVARFMWNV ITELKKDKVI ILTTHSMLEC SAVCDRLTIM
KSGKMMCLGS IQHIKDKFGS GYSIDVKFKK EYLLSGINLF QKELPNAKLV DHHDLSASFE
LPNSLDSPIQ LSKIFSIIER NLKPILNDYS VGQTSIDHIF LKLTNLNQQK IKNQQKESIE
NHIIDINNNN NNNNNNSYLK NHKKTTSNNS ILTNNSTTKN FGSSNFLDLE SDNTYLNNLK
YLEDDDFNIE MPPYQNSLKK SF
