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BABA2_XENLA
ID   BABA2_XENLA             Reviewed;         384 AA.
AC   Q6GPL9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=BRISC and BRCA1-A complex member 2;
DE   AltName: Full=BRCA1-A complex subunit BRE;
DE   AltName: Full=BRCA1/BRCA2-containing complex subunit 45;
DE   AltName: Full=Brain and reproductive organ-expressed protein;
GN   Name=babam2; Synonyms=bre;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the BRCA1-A complex, a complex that specifically
CC       recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA
CC       lesions sites, leading to target the brca1-bard1 heterodimer to sites
CC       of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also
CC       possesses deubiquitinase activity that specifically removes 'Lys-63'-
CC       linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it
CC       acts as an adapter that bridges the interaction between babam1/nba1 and
CC       the rest of the complex, thereby being required for the complex
CC       integrity and modulating the E3 ubiquitin ligase activity of the brca1-
CC       bard1 heterodimer. Component of the BRISC complex, a multiprotein
CC       complex that specifically cleaves 'Lys-63'-linked ubiquitin in various
CC       substrates. Within the BRISC complex, acts as an adapter that bridges
CC       the interaction between babam1/nba1 and the rest of the complex,
CC       thereby being required for the complex integrity. The BRISC complex is
CC       required for normal mitotic spindle assembly and microtubule attachment
CC       to kinetochores via its role in deubiquitinating numa1. The BRISC
CC       complex plays a role in interferon signaling via its role in the
CC       deubiquitination of the interferon receptor ifnar1; deubiquitination
CC       increases ifnar1 activity by enhancing its stability and cell surface
CC       expression. Down-regulates the response to bacterial lipopolysaccharide
CC       (LPS) via its role in ifnar1 deubiquitination. May play a role in
CC       homeostasis or cellular differentiation in cells of neural, epithelial
CC       and germline origins. May also act as a death receptor-associated anti-
CC       apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
CC       {ECO:0000250|UniProtKB:Q9NXR7}.
CC   -!- SUBUNIT: Component of the ARISC complex, at least composed of
CC       uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and babam1/nba1. Component
CC       of the BRCA1-A complex, at least composed of brca1, bard1, uimc1/rap80,
CC       abraxas1, brcc3/brcc36, babam2 and babam1/nba1. In the BRCA1-A complex,
CC       interacts directly with abraxas1, brcc3/brcc36 and babam1/nba1. Binds
CC       polyubiquitin. Component of the BRISC complex, at least composed of
CC       abraxas2, brcc3/brcc36, babam2 and babam1/nba1.
CC       {ECO:0000250|UniProtKB:Q9NXR7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NXR7}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9NXR7}. Note=Localizes at sites of DNA damage
CC       at double-strand breaks (DSBs). {ECO:0000250|UniProtKB:Q9NXR7}.
CC   -!- DOMAIN: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like)
CC       regions. These regions lack the critical Cys residues required for
CC       ubiquitination but retain the ability to bind ubiquitin.
CC       {ECO:0000250|UniProtKB:Q9NXR7}.
CC   -!- SIMILARITY: Belongs to the BABAM2 family. {ECO:0000255}.
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DR   EMBL; BC073095; AAH73095.1; -; mRNA.
DR   RefSeq; NP_001085651.1; NM_001092182.1.
DR   AlphaFoldDB; Q6GPL9; -.
DR   SMR; Q6GPL9; -.
DR   DNASU; 444077; -.
DR   GeneID; 444077; -.
DR   KEGG; xla:444077; -.
DR   CTD; 444077; -.
DR   Xenbase; XB-GENE-1032926; babam2.L.
DR   OrthoDB; 831092at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 444077; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0070531; C:BRCA1-A complex; ISS:UniProtKB.
DR   GO; GO:0070552; C:BRISC complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; ISS:UniProtKB.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   InterPro; IPR010358; BRE.
DR   PANTHER; PTHR15189; PTHR15189; 1.
DR   Pfam; PF06113; BRE; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell cycle; Cell division; Chromatin regulator; Cytoplasm;
KW   DNA damage; DNA repair; Mitosis; Nucleus; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..384
FT                   /note="BRISC and BRCA1-A complex member 2"
FT                   /id="PRO_0000373937"
FT   REGION          30..147
FT                   /note="UEV-like 1"
FT   REGION          275..365
FT                   /note="UEV-like 2"
SQ   SEQUENCE   384 AA;  43592 MW;  28D6C1E929EEF25A CRC64;
     MSPEVTLNRI SPALSPFISS VVRNGKVGLD STNCLRITDL KSGCTSLTPG PSCDRFKLHI
     PYAGETLKWD IIFNASYPEL PPDFIFGEDA EFLPDPSALH NLSEWNPSDP ECLLLVVKEL
     VQQYHQYQCS RLSESSRLMF EYQTLQEEPQ YGLNMEIYAG KKNNWTGEFS ARFLLKMPVD
     FSNIPIYLLK DSNEDPGEDV ALLSVSFEDA EATQVFPKLF LSPRIEHALG GSSALHIPVF
     PSGSCLIDYV PQVCQLLTNK VQYVIQGYHK RREYIAAFLS HFGTGVVEYD AEGFTKLTLL
     LSWKDFCFLV HTVDLPLYFP RDQPTLTFQS VYHFTNSGQL YSQAQKNYPY SPRWDGNEMA
     KRAKAYFRSF VPQFQEAAFA NGKL
 
 
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