ID   BAC79_WEICO             Reviewed;          38 AA.
AC   C0HLU4;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=Bacteriocin BAC79 {ECO:0000303|Ref.1};
DE   Flags: Fragments;
OS   Weissella confusa (Lactobacillus confusus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Weissella.
OX   NCBI_TaxID=1583 {ECO:0000303|Ref.1};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, AND
RP   BIOPHYSICOCHEMICAL PROPERTIES.
RC   STRAIN=AJ79 {ECO:0000303|Ref.1};
RX   DOI=10.9790/3008-1302031724;
RA   Dubey A.K., Kadirvelu J.;
RT   "Purification and characterization of an antibacterial peptide
RT   (Bacteriocin) produced by Weissella confusa AJ79.";
RL   IOSR J. Pharm. Biol. Sci. 13:17-24(2018).
CC   -!- FUNCTION: Has antibacterial activity against a wide spectrum of Gram-
CC       positive and Gram-negative bacteria, including L.monocytogenes which is
CC       inhibited through disruption of the cell membrane. {ECO:0000269|Ref.1}.
CC   -!- ACTIVITY REGULATION: The antimicrobial activity of BAC79 was completely
CC       lost after treatment with enzymes trypsin, pepsin, proteinase-K, and
CC       carboxypeptidase, while there was no loss of activity with either
CC       amylase or lipase. {ECO:0000269|Ref.1}.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is between 2 to 4. Active from pH 2 to 6.
CC         {ECO:0000269|Ref.1};
CC       Temperature dependence:
CC         Thermostable. Retains activity up to 100 degrees Celsius, and when
CC         exposed to 121 degrees Celsius. Also retains activity after storage
CC         at 4 degrees Celsius for 4 months. {ECO:0000269|Ref.1};
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DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0051673; P:membrane disruption in another organism; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing.
FT   CHAIN           1..38
FT                   /note="Bacteriocin BAC79"
FT                   /id="PRO_0000454657"
FT   NON_CONS        8..9
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        19..20
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_TER         38
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   38 AA;  4264 MW;  0B7A34863D940EF9 CRC64;
     AIAVELARDV FEAIQTLSRG SVFQDMPLVS NKELMDLR