RS21_PIG
ID RS21_PIG Reviewed; 83 AA.
AC P63221; A1XQV0; P35265;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=40S ribosomal protein S21;
GN Name=RPS21;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RA Winteroe A.K., Fredholm M.;
RT "Evaluation and characterization of a porcine small intestine cDNA
RT library.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Longissimus dorsi muscle;
RA Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.;
RT "Generation and analysis of cDNA sequences derived from a porcine skeletal
RT muscle library.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007744|PDB:3J7P, ECO:0007744|PDB:3J7R}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=24930395; DOI=10.1016/j.cell.2014.05.024;
RA Voorhees R.M., Fernandez I.S., Scheres S.H., Hegde R.S.;
RT "Structure of the mammalian ribosome-Sec61 complex to 3.4 A resolution.";
RL Cell 157:1632-1643(2014).
CC -!- SUBUNIT: Component of the 40S small ribosomal subunit.
CC {ECO:0000269|PubMed:24930395}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P63220}. Cytoplasm
CC {ECO:0000269|PubMed:24930395}. Rough endoplasmic reticulum
CC {ECO:0000269|PubMed:24930395}. Note=Detected on cytosolic polysomes (By
CC similarity). Detected in ribosomes that are associated with the rough
CC endoplasmic reticulum. {ECO:0000250|UniProtKB:P63220,
CC ECO:0000269|PubMed:24930395}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS21 family.
CC {ECO:0000305}.
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DR EMBL; Z84015; CAB06311.1; -; mRNA.
DR EMBL; DQ629172; ABK55656.1; -; mRNA.
DR RefSeq; NP_001090949.1; NM_001097480.2.
DR RefSeq; XP_003128784.1; XM_003128736.5.
DR PDB; 3J7P; EM; 3.50 A; SV=1-83.
DR PDB; 3J7R; EM; 3.90 A; SV=1-83.
DR PDBsum; 3J7P; -.
DR PDBsum; 3J7R; -.
DR AlphaFoldDB; P63221; -.
DR SMR; P63221; -.
DR STRING; 9823.ENSSSCP00000020869; -.
DR PaxDb; P63221; -.
DR PeptideAtlas; P63221; -.
DR PRIDE; P63221; -.
DR Ensembl; ENSSSCT00000026530; ENSSSCP00000020869; ENSSSCG00000021825.
DR Ensembl; ENSSSCT00005056860; ENSSSCP00005035014; ENSSSCG00005035582.
DR Ensembl; ENSSSCT00025067292; ENSSSCP00025028798; ENSSSCG00025049418.
DR Ensembl; ENSSSCT00030037958; ENSSSCP00030017427; ENSSSCG00030027135.
DR Ensembl; ENSSSCT00035012676; ENSSSCP00035004281; ENSSSCG00035010134.
DR Ensembl; ENSSSCT00040096625; ENSSSCP00040042937; ENSSSCG00040070426.
DR Ensembl; ENSSSCT00045038079; ENSSSCP00045026459; ENSSSCG00045022298.
DR Ensembl; ENSSSCT00050101354; ENSSSCP00050044079; ENSSSCG00050074066.
DR Ensembl; ENSSSCT00055023636; ENSSSCP00055018690; ENSSSCG00055012074.
DR Ensembl; ENSSSCT00060039367; ENSSSCP00060016691; ENSSSCG00060029127.
DR Ensembl; ENSSSCT00065048260; ENSSSCP00065020820; ENSSSCG00065035426.
DR Ensembl; ENSSSCT00070041136; ENSSSCP00070034534; ENSSSCG00070020687.
DR GeneID; 100037996; -.
DR GeneID; 100518848; -.
DR KEGG; ssc:100037996; -.
DR KEGG; ssc:100518848; -.
DR CTD; 6227; -.
DR VGNC; VGNC:108734; RPS21.
DR eggNOG; KOG3486; Eukaryota.
DR GeneTree; ENSGT00390000017515; -.
DR HOGENOM; CLU_167122_2_0_1; -.
DR InParanoid; P63221; -.
DR OMA; ALCGYIR; -.
DR OrthoDB; 881551at2759; -.
DR TreeFam; TF300167; -.
DR Reactome; R-SSC-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SSC-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SSC-72649; Translation initiation complex formation.
DR Reactome; R-SSC-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-SSC-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-SSC-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SSC-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000008227; Chromosome 17.
DR Proteomes; UP000314985; Chromosome 17.
DR Bgee; ENSSSCG00000021825; Expressed in blood and 43 other tissues.
DR Genevisible; P63221; SS.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000461; P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 3.30.1230.20; -; 1.
DR InterPro; IPR001931; Ribosomal_S21e.
DR InterPro; IPR018279; Ribosomal_S21e_CS.
DR InterPro; IPR038579; Ribosomal_S21e_sf.
DR PANTHER; PTHR10442; PTHR10442; 1.
DR Pfam; PF01249; Ribosomal_S21e; 1.
DR PIRSF; PIRSF002148; Ribosomal_S21e; 1.
DR PROSITE; PS00996; RIBOSOMAL_S21E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Endoplasmic reticulum;
KW Isopeptide bond; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Ubl conjugation.
FT CHAIN 1..83
FT /note="40S ribosomal protein S21"
FT /id="PRO_0000194732"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P63220"
FT MOD_RES 81
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P63220"
FT CROSSLNK 41
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P63220"
SQ SEQUENCE 83 AA; 9111 MW; 6794AC1292A06BD3 CRC64;
MQNDAGEFVD LYVPRKCSAS NRIIGAKDHA SIQMNVAEVD KVTGRFNGQF KTYAICGAIR
RMGESDDSIL RLAKADGIVS KNF
