ID   RS21_RAT                Reviewed;          83 AA.
AC   P05765;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 139.
DE   RecName: Full=40S ribosomal protein S21;
GN   Name=Rps21;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   PROTEIN SEQUENCE, AND ACETYLATION AT MET-1.
RX   PubMed=3910104; DOI=10.1021/bi00346a058;
RA   Itoh T., Otaka E., Matsui K.A.;
RT   "Primary structures of ribosomal protein YS25 from Saccharomyces cerevisiae
RT   and its counterparts from Schizosaccharomyces pombe and rat liver.";
RL   Biochemistry 24:7418-7423(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   PubMed=7654221; DOI=10.1006/bbrc.1995.2233;
RA   Chan Y.-L., Olvera J., Wool I.G.;
RT   "The primary structures of rat ribosomal proteins: the characterization of
RT   the cDNAs for S21 and L39, corrections in the sequences of L7 and L18a, and
RT   the identification of L33.";
RL   Biochem. Biophys. Res. Commun. 213:1042-1050(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Component of the 40S small ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P63220}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P63220}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P63220}. Rough endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:P63221}. Note=Detected on cytosolic polysomes
CC       (By similarity). Detected in ribosomes that are associated with the
CC       rough endoplasmic reticulum (By similarity).
CC       {ECO:0000250|UniProtKB:P63220, ECO:0000250|UniProtKB:P63221}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS21 family.
CC       {ECO:0000305}.
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DR   EMBL; X79059; CAA55658.1; -; mRNA.
DR   EMBL; BC058464; AAH58464.1; -; mRNA.
DR   PIR; C23862; R3RT21.
DR   RefSeq; NP_112373.1; NM_031111.1.
DR   AlphaFoldDB; P05765; -.
DR   SMR; P05765; -.
DR   BioGRID; 249647; 1.
DR   IntAct; P05765; 3.
DR   MINT; P05765; -.
DR   STRING; 10116.ENSRNOP00000042935; -.
DR   iPTMnet; P05765; -.
DR   PhosphoSitePlus; P05765; -.
DR   jPOST; P05765; -.
DR   PaxDb; P05765; -.
DR   PRIDE; P05765; -.
DR   GeneID; 81775; -.
DR   KEGG; rno:81775; -.
DR   CTD; 6227; -.
DR   RGD; 621038; Rps21.
DR   eggNOG; KOG3486; Eukaryota.
DR   InParanoid; P05765; -.
DR   OrthoDB; 1571849at2759; -.
DR   PhylomeDB; P05765; -.
DR   TreeFam; TF300167; -.
DR   Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-RNO-72649; Translation initiation complex formation.
DR   Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:P05765; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR   GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
DR   GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0000461; P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.30.1230.20; -; 1.
DR   InterPro; IPR001931; Ribosomal_S21e.
DR   InterPro; IPR018279; Ribosomal_S21e_CS.
DR   InterPro; IPR038579; Ribosomal_S21e_sf.
DR   PANTHER; PTHR10442; PTHR10442; 1.
DR   Pfam; PF01249; Ribosomal_S21e; 1.
DR   PIRSF; PIRSF002148; Ribosomal_S21e; 1.
DR   PROSITE; PS00996; RIBOSOMAL_S21E; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..83
FT                   /note="40S ribosomal protein S21"
FT                   /id="PRO_0000194733"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000269|PubMed:3910104"
FT   MOD_RES         81
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P63220"
SQ   SEQUENCE   83 AA;  9127 MW;  6790A08AEF4D0DB5 CRC64;
     MQNDAGEFVD LYVPRKCSAS NRIIAAKDHA SIQMNVAEVD RSTGRFNGQF KTYGICGAIR
     RMGESDDSIL RLAKADGIVS KNF