BACC_DROME
ID BACC_DROME Reviewed; 152 AA.
AC Q9VQF7;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Bacchus {ECO:0000303|PubMed:23142736};
GN Name=Bacc {ECO:0000312|FlyBase:FBgn0031453};
GN ORFNames=CG9894 {ECO:0000312|FlyBase:FBgn0031453};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL48971.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL48971.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAL48971.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:ACO53099.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:ACO53099.1};
RA Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., Celniker S.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:ANY27544.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:ANY27544.1};
RA Wan K., Booth B., Spirohn K., Hao T., Hu Y., Calderwood M., Hill D.,
RA Mohr S., Vidal M., Celniker S., Perrimon N.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP DEVELOPMENTAL STAGE.
RX PubMed=11900973; DOI=10.1016/s0925-4773(02)00010-2;
RA Brody T., Stivers C., Nagle J., Odenwald W.F.;
RT "Identification of novel Drosophila neural precursor genes using a
RT differential embryonic head cDNA screen.";
RL Mech. Dev. 113:41-59(2002).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=23142736; DOI=10.1016/j.neuropharm.2012.10.013;
RA Chen J., Wang Y., Zhang Y., Shen P.;
RT "Mutations in Bacchus reveal a tyramine-dependent nuclear regulator for
RT acute ethanol sensitivity in Drosophila.";
RL Neuropharmacology 67:25-31(2013).
CC -!- FUNCTION: Negatively regulates tyramine beta-hydroxylase tbh and thus
CC the conversion of tyramine (TA) to octopamine (OA). In tyrosine
CC decarboxylase 2 (Tdc2) neurons, acts in an amine-mediated signaling
CC pathway to negatively regulate acute ethanol sensitivity probably via
CC tbh-mediated depletion of TA. {ECO:0000269|PubMed:23142736}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23142736}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain.
CC {ECO:0000269|PubMed:23142736}.
CC -!- DEVELOPMENTAL STAGE: In embryos, first expressed in the ganglion mother
CC cells (GMCs) of the central nervous system (CNS) and the sensory organ
CC precursors (SOPs) of the peripheral nervous system (PNS). At stage 14,
CC it is no longer detected in the lateral PNS. Expressed in the antenno-
CC maxillary complex from stage 14 and throughout stage 15.
CC {ECO:0000269|PubMed:11900973}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in neurons causes a
CC reduction in sensitivity to ethanol intoxication.
CC {ECO:0000269|PubMed:23142736}.
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DR EMBL; AE014134; AAF51217.1; -; Genomic_DNA.
DR EMBL; AE014134; AAN10413.1; -; Genomic_DNA.
DR EMBL; AE014134; AFH03527.1; -; Genomic_DNA.
DR EMBL; AE014134; AGB92497.1; -; Genomic_DNA.
DR EMBL; AY071349; AAL48971.1; -; mRNA.
DR EMBL; BT081984; ACO53099.1; -; mRNA.
DR EMBL; KX531734; ANY27544.1; -; mRNA.
DR RefSeq; NP_001245850.1; NM_001258921.3.
DR RefSeq; NP_001259960.1; NM_001273031.2.
DR RefSeq; NP_608706.1; NM_134862.4.
DR RefSeq; NP_722833.1; NM_164498.3.
DR AlphaFoldDB; Q9VQF7; -.
DR IntAct; Q9VQF7; 2.
DR STRING; 7227.FBpp0297923; -.
DR PaxDb; Q9VQF7; -.
DR PRIDE; Q9VQF7; -.
DR DNASU; 33462; -.
DR EnsemblMetazoa; FBtr0077713; FBpp0077397; FBgn0031453.
DR EnsemblMetazoa; FBtr0077714; FBpp0077398; FBgn0031453.
DR EnsemblMetazoa; FBtr0307080; FBpp0297923; FBgn0031453.
DR EnsemblMetazoa; FBtr0335125; FBpp0307124; FBgn0031453.
DR GeneID; 33462; -.
DR KEGG; dme:Dmel_CG9894; -.
DR UCSC; CG9894-RA; d. melanogaster.
DR CTD; 33462; -.
DR FlyBase; FBgn0031453; Bacc.
DR VEuPathDB; VectorBase:FBgn0031453; -.
DR eggNOG; ENOG502T742; Eukaryota.
DR HOGENOM; CLU_1733366_0_0_1; -.
DR InParanoid; Q9VQF7; -.
DR OMA; SCTNRRR; -.
DR SignaLink; Q9VQF7; -.
DR BioGRID-ORCS; 33462; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Bacc; fly.
DR GenomeRNAi; 33462; -.
DR PRO; PR:Q9VQF7; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031453; Expressed in wing disc and 32 other tissues.
DR GO; GO:0005654; C:nucleoplasm; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0048149; P:behavioral response to ethanol; IMP:FlyBase.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..152
FT /note="Bacchus"
FT /id="PRO_0000438107"
FT REGION 29..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..152
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 152 AA; 15460 MW; 60770C7879935FF9 CRC64;
MSAATEQQNN GDVAVEKVAA DDVSAVKDDL KAKAAAEDKA AAADAAGDAA DNGTSKDGED
AADAAAAAPA KESVKGTKRP AEAKSAESKK AKKAAAADGD SDEEEALEEI IEGDSEIESD
EYDIPYDGEE DDIECDDDDD DNDDGSGSDD QA
