ID   BACD2_CHICK             Reviewed;         314 AA.
AC   Q5F3E8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2;
DE   AltName: Full=BTB/POZ domain-containing protein TNFAIP1;
GN   Name=TNFAIP1; ORFNames=RCJMB04_19f9;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin-protein ligase complex involved in regulation of cytoskeleton
CC       structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the
CC       ubiquitination of target proteins, leading to their degradation by the
CC       proteasome (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at
CC       least composed of CUL3, TNFAIP1/BACURD2 and RBX1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BACURD family. {ECO:0000305}.
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DR   EMBL; AJ851702; CAH65336.1; -; mRNA.
DR   RefSeq; NP_001025897.1; NM_001030726.1.
DR   RefSeq; XP_015151288.1; XM_015295802.1.
DR   RefSeq; XP_015151290.1; XM_015295804.1.
DR   AlphaFoldDB; Q5F3E8; -.
DR   SMR; Q5F3E8; -.
DR   STRING; 9031.ENSGALP00000009155; -.
DR   PaxDb; Q5F3E8; -.
DR   Ensembl; ENSGALT00000009169; ENSGALP00000009155; ENSGALG00000005737.
DR   GeneID; 417672; -.
DR   KEGG; gga:417672; -.
DR   CTD; 7126; -.
DR   VEuPathDB; HostDB:geneid_417672; -.
DR   eggNOG; KOG2716; Eukaryota.
DR   GeneTree; ENSGT00940000159315; -.
DR   HOGENOM; CLU_060008_0_0_1; -.
DR   InParanoid; Q5F3E8; -.
DR   OrthoDB; 1306250at2759; -.
DR   PhylomeDB; Q5F3E8; -.
DR   TreeFam; TF315649; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5F3E8; -.
DR   Proteomes; UP000000539; Chromosome 19.
DR   Bgee; ENSGALG00000005737; Expressed in spermatid and 14 other tissues.
DR   ExpressionAtlas; Q5F3E8; baseline.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; ISS:UniProtKB.
DR   GO; GO:0035024; P:negative regulation of Rho protein signal transduction; ISS:UniProtKB.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0043149; P:stress fiber assembly; ISS:UniProtKB.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR045068; BACURD1-3.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR11145; PTHR11145; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..314
FT                   /note="BTB/POZ domain-containing adapter for CUL3-mediated
FT                   RhoA degradation protein 2"
FT                   /id="PRO_0000331250"
FT   DOMAIN          32..100
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ   SEQUENCE   314 AA;  36032 MW;  52EA6A2E1493BF1C CRC64;
     MSGDTCLTTT LCPAVGPKPK TCSFKVGSLG NKYVRLNVGG SLYYTTVQVL TRHDTMLKAM
     FSGRMEVLTD KEGWILIDRC GKHFGTILNY LRDDTIALPK HRQEIKELMA EAKYYLIQGL
     VDMCQAALQD KKDLYEPVCN IPIITSPKEE ERLIESSMKP VVKLLYNRSN NKYSYTSNSD
     DNLLKNIELF DKLSLRFNGR VLFIKDVIGD EICCWSFYGQ GRKLAEVCCT SIVYATEKKQ
     TKVEFPEARI YEETLNVLLY ETPRVPDNSL LEATSRSRSQ ASHSEDDDGF ELRDRVRRIH
     VKRYSTYDDR QLGH