RS23A_SCHPO
ID RS23A_SCHPO Reviewed; 143 AA.
AC P0CT75; P79057;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=40S ribosomal protein S23-A;
GN Name=rps23; Synonyms=rps23a; ORFNames=SPAC23C11.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kawamukai M.;
RT "S.pombe ribosomal protein S23 homolog.";
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP HYDROXYLATION AT PRO-62.
RX PubMed=24550462; DOI=10.1073/pnas.1311750111;
RA Loenarz C., Sekirnik R., Thalhammer A., Ge W., Spivakovsky E.,
RA Mackeen M.M., McDonough M.A., Cockman M.E., Kessler B.M., Ratcliffe P.J.,
RA Wolf A., Schofield C.J.;
RT "Hydroxylation of the eukaryotic ribosomal decoding center affects
RT translational accuracy.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:4019-4024(2014).
CC -!- PTM: Hydroxylation at Pro-62 affects translation termination
CC efficiency. {ECO:0000305|PubMed:24550462}.
CC -!- MISCELLANEOUS: There are two genes for S23 in S.pombe.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS12 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA19233.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB001288; BAA19233.1; ALT_INIT; mRNA.
DR EMBL; CU329670; CAB11155.1; -; Genomic_DNA.
DR PIR; T38240; T38240.
DR RefSeq; NP_593633.1; NM_001019064.2.
DR RefSeq; NP_596187.1; NM_001022106.2.
DR AlphaFoldDB; P0CT75; -.
DR SMR; P0CT75; -.
DR STRING; 4896.SPAC23C11.02c.1; -.
DR iPTMnet; P0CT75; -.
DR PaxDb; P0CT75; -.
DR EnsemblFungi; SPAC23C11.02c.1; SPAC23C11.02c.1:pep; SPAC23C11.02c.
DR EnsemblFungi; SPBP4H10.13.1; SPBP4H10.13.1:pep; SPBP4H10.13.
DR GeneID; 2541369; -.
DR GeneID; 2542012; -.
DR KEGG; spo:SPAC23C11.02c; -.
DR KEGG; spo:SPBP4H10.13; -.
DR PomBase; SPAC23C11.02c; rps23.
DR VEuPathDB; FungiDB:SPAC23C11.02c; -.
DR VEuPathDB; FungiDB:SPBP4H10.13; -.
DR eggNOG; KOG1749; Eukaryota.
DR OMA; KFRWSQR; -.
DR PhylomeDB; P0CT75; -.
DR Reactome; R-SPO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SPO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-SPO-72649; Translation initiation complex formation.
DR Reactome; R-SPO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-SPO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-SPO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-SPO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-SPO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SPO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P0CT75; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISO:PomBase.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005840; C:ribosome; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:PomBase.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:PomBase.
DR GO; GO:2000640; P:positive regulation of SREBP signaling pathway; IMP:PomBase.
DR GO; GO:0006606; P:protein import into nucleus; IMP:PomBase.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd03367; Ribosomal_S23; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006032; Ribosomal_S12/S23.
DR InterPro; IPR005680; Ribosomal_S23_euk/arc.
DR PANTHER; PTHR11652; PTHR11652; 1.
DR Pfam; PF00164; Ribosom_S12_S23; 1.
DR PIRSF; PIRSF002133; Ribosomal_S12/S23; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00982; uS12_E_A; 1.
DR PROSITE; PS00055; RIBOSOMAL_S12; 1.
PE 1: Evidence at protein level;
KW Hydroxylation; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..143
FT /note="40S ribosomal protein S23-A"
FT /id="PRO_0000146479"
FT MOD_RES 62
FT /note="3,4-dihydroxyproline"
FT /evidence="ECO:0000269|PubMed:24550462"
SQ SEQUENCE 143 AA; 15655 MW; 8511D5838F472D53 CRC64;
MGKPAGLNAA RKLRNHRREE RWADAHYKKR LLGTAYKSSP FGGSSHAKGI VVEKIGVEAK
QPNSAIRKCV RVQLIKNGKK VTAFVPHDGC LNFVDENDEV LLSGFGRKGK AKGDIPGVRF
KVVKVAGVGL SALFHEKKEK PRA
