ID   BACD2_XENLA             Reviewed;         319 AA.
AC   Q5EAX2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2;
DE   AltName: Full=BTB/POZ domain-containing protein TNFAIP1;
GN   Name=tnfaip1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin-protein ligase complex involved in regulation of cytoskeleton
CC       structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the
CC       ubiquitination of target proteins, leading to their degradation by the
CC       proteasome (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at
CC       least composed of cul3, tnfaip1/bacurd2 and rbx1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BACURD family. {ECO:0000305}.
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DR   EMBL; BC090212; AAH90212.1; -; mRNA.
DR   RefSeq; NP_001089279.1; NM_001095810.1.
DR   AlphaFoldDB; Q5EAX2; -.
DR   SMR; Q5EAX2; -.
DR   DNASU; 734327; -.
DR   GeneID; 734327; -.
DR   CTD; 734327; -.
DR   Xenbase; XB-GENE-6251466; tnfaip1.L.
DR   OrthoDB; 1306250at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 734327; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR   GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; ISS:UniProtKB.
DR   GO; GO:0035024; P:negative regulation of Rho protein signal transduction; ISS:UniProtKB.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0043149; P:stress fiber assembly; ISS:UniProtKB.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR045068; BACURD1-3.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR11145; PTHR11145; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..319
FT                   /note="BTB/POZ domain-containing adapter for CUL3-mediated
FT                   RhoA degradation protein 2"
FT                   /id="PRO_0000331251"
FT   DOMAIN          31..99
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ   SEQUENCE   319 AA;  36488 MW;  08C456DEF82CD9B3 CRC64;
     MSGDTCLTAV CPASGAKPKT YSFKGGCLGN KYIRLNVGGC LYYTTVQVLT RHDTMLKAMF
     SGRMEVLTDK EGWILIDRCG KHFGSILNYL RDDTIALPKS RHEIKELMAE AKYYLIQGLV
     DKCQTALQDT NDTYEAVCNI PIITSPKEEE KLIESSAKPV VKLLYNRSNN KYSYTSNSDD
     HLLKNIELFD KLSLRFNGRV LFIKDVIGDE ICCWSFYGQG RKLAEVCCTS IVYATEKKQT
     KVEFPEARIY EETLNVLLYE TPRVPDNSLL EATSRIRSQA SHSEDDDGFE LRDRVRRIHV
     KRYSTYDDRQ LGHQSAYRD