ID   BACD2_XENTR             Reviewed;         319 AA.
AC   Q28DC9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2;
DE   AltName: Full=BTB/POZ domain-containing protein TNFAIP1;
GN   Name=tnfaip1; ORFNames=TEgg017p05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin-protein ligase complex involved in regulation of cytoskeleton
CC       structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the
CC       ubiquitination of target proteins, leading to their degradation by the
CC       proteasome (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at
CC       least composed of cul3, tnfaip1/bacurd2 and rbx1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BACURD family. {ECO:0000305}.
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DR   EMBL; CR855581; CAJ82277.1; -; mRNA.
DR   EMBL; BC135236; AAI35237.1; -; mRNA.
DR   RefSeq; NP_001016809.1; NM_001016809.2.
DR   RefSeq; XP_012812454.1; XM_012957000.2.
DR   RefSeq; XP_012812455.1; XM_012957001.2.
DR   RefSeq; XP_017946757.1; XM_018091268.1.
DR   AlphaFoldDB; Q28DC9; -.
DR   SMR; Q28DC9; -.
DR   STRING; 8364.ENSXETP00000042121; -.
DR   PaxDb; Q28DC9; -.
DR   DNASU; 549563; -.
DR   Ensembl; ENSXETT00000042121; ENSXETP00000042121; ENSXETG00000019443.
DR   GeneID; 549563; -.
DR   KEGG; xtr:549563; -.
DR   CTD; 7126; -.
DR   Xenbase; XB-GENE-943703; tnfaip1.
DR   eggNOG; KOG2716; Eukaryota.
DR   HOGENOM; CLU_060008_0_0_1; -.
DR   InParanoid; Q28DC9; -.
DR   PhylomeDB; Q28DC9; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000019443; Expressed in 2-cell stage embryo and 14 other tissues.
DR   ExpressionAtlas; Q28DC9; baseline.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR   GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; ISS:UniProtKB.
DR   GO; GO:0035024; P:negative regulation of Rho protein signal transduction; ISS:UniProtKB.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0043149; P:stress fiber assembly; ISS:UniProtKB.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR045068; BACURD1-3.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR11145; PTHR11145; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..319
FT                   /note="BTB/POZ domain-containing adapter for CUL3-mediated
FT                   RhoA degradation protein 2"
FT                   /id="PRO_0000331252"
FT   DOMAIN          31..99
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ   SEQUENCE   319 AA;  36480 MW;  F0C57B0B0DAF24E5 CRC64;
     MSGDTCLTAV CPASGAKPKT YSFKGGCLGN KYIRLNVGGC LYYTTVQVLT RHDTMLKAMF
     SGRMEVLTDK EGWILIDRCG KHFGSILNYL RDDTITLPKS RHEVKELMAE AKYYLIQGLV
     DKCQAALQDK NDTYEAVCNI PIITSPKEEE KLIESSAKPV VKLLYNRSNN KYSYTSNSDD
     NLLKNIELFD KLSLRFNGRV LFIKDVIGDE ICCWSFYGQG RKLAEVCCTS IVYATEKKQT
     KVEFPEARIY EETLNVLLYE TPRVPDNSLL EATSRTRSQA SHSEDDEGFE LRDRVRRIHV
     KRYSTYDDRQ LGHQSAYRD