RS24_RAT
ID RS24_RAT Reviewed; 133 AA.
AC P62850; P16632; Q6PEC9;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=40S ribosomal protein S24;
GN Name=Rps24;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=2335205; DOI=10.1016/0014-5793(90)80203-u;
RA Chan Y.-L., Paz V., Olvera J., Wool I.G.;
RT "The primary structure of rat ribosomal protein S24.";
RL FEBS Lett. 262:253-255(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for processing of pre-rRNA and maturation of 40S
CC ribosomal subunits. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P62850-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P62850-2; Sequence=VSP_011367;
CC Name=3;
CC IsoId=P62850-3; Sequence=VSP_011368;
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS24 family.
CC {ECO:0000305}.
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DR EMBL; X52445; CAA36684.1; -; mRNA.
DR EMBL; X51538; CAA35918.1; -; mRNA.
DR EMBL; BC058140; AAH58140.1; -; mRNA.
DR PIR; S09197; R3RT24.
DR RefSeq; NP_112374.1; NM_031112.1. [P62850-1]
DR RefSeq; XP_006252593.1; XM_006252531.3. [P62850-3]
DR RefSeq; XP_006252594.1; XM_006252532.3. [P62850-3]
DR RefSeq; XP_006252595.1; XM_006252533.2. [P62850-2]
DR AlphaFoldDB; P62850; -.
DR SMR; P62850; -.
DR BioGRID; 249648; 1.
DR IntAct; P62850; 9.
DR MINT; P62850; -.
DR STRING; 10116.ENSRNOP00000048903; -.
DR iPTMnet; P62850; -.
DR PhosphoSitePlus; P62850; -.
DR SwissPalm; P62850; -.
DR jPOST; P62850; -.
DR PaxDb; P62850; -.
DR PRIDE; P62850; -.
DR Ensembl; ENSRNOT00000013588; ENSRNOP00000013588; ENSRNOG00000010189. [P62850-2]
DR Ensembl; ENSRNOT00000101331; ENSRNOP00000082107; ENSRNOG00000010189. [P62850-3]
DR GeneID; 81776; -.
DR KEGG; rno:81776; -.
DR UCSC; RGD:621040; rat. [P62850-1]
DR CTD; 6229; -.
DR RGD; 621040; Rps24.
DR VEuPathDB; HostDB:ENSRNOG00000010189; -.
DR eggNOG; KOG3424; Eukaryota.
DR GeneTree; ENSGT00390000000153; -.
DR InParanoid; P62850; -.
DR OMA; TFGFRTH; -.
DR OrthoDB; 1465790at2759; -.
DR PhylomeDB; P62850; -.
DR TreeFam; TF314134; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62850; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000010189; Expressed in ovary and 19 other tissues.
DR ExpressionAtlas; P62850; baseline and differential.
DR Genevisible; P62850; RN.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0005840; C:ribosome; NAS:UniProtKB.
DR GO; GO:0015935; C:small ribosomal subunit; IDA:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0031369; F:translation initiation factor binding; IPI:UniProtKB.
DR GO; GO:0034101; P:erythrocyte homeostasis; ISO:RGD.
DR GO; GO:0097421; P:liver regeneration; IEP:RGD.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:RGD.
DR GO; GO:0006364; P:rRNA processing; ISO:RGD.
DR GO; GO:0006413; P:translational initiation; NAS:UniProtKB.
DR HAMAP; MF_00545; Ribosomal_S24e; 1.
DR InterPro; IPR012678; Ribosomal_L23/L15e_core_dom_sf.
DR InterPro; IPR001976; Ribosomal_S24e.
DR InterPro; IPR018098; Ribosomal_S24e_CS.
DR PANTHER; PTHR10496; PTHR10496; 1.
DR Pfam; PF01282; Ribosomal_S24e; 1.
DR SUPFAM; SSF54189; SSF54189; 1.
DR PROSITE; PS00529; RIBOSOMAL_S24E; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT CHAIN 1..133
FT /note="40S ribosomal protein S24"
FT /id="PRO_0000137626"
FT REGION 92..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..118
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P62847"
FT MOD_RES 9
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P62847"
FT CROSSLNK 37
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62847"
FT VAR_SEQ 131..133
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_011367"
FT VAR_SEQ 131..133
FT /note="PKE -> K (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_011368"
SQ SEQUENCE 133 AA; 15423 MW; CE9065C0764D60A6 CRC64;
MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT TPDVIFVFGF
RTHFGGGKTT GFGMIYDSLD YAKKNEPKHR LARHGLYEKK KTSRKQRKER KNRMKKVRGT
AKANVGAGKK PKE
