ABCA4_DICDI
ID ABCA4_DICDI Reviewed; 1615 AA.
AC Q555Z5; Q86IX7; Q8T6J3;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=ABC transporter A family member 4;
DE AltName: Full=ABC transporter ABCA.4;
GN Name=abcA4; ORFNames=DDB_G0274121;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000305}.
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DR EMBL; AF465306; AAL85297.1; -; Genomic_DNA.
DR EMBL; AAFI02000012; EAL69953.1; -; Genomic_DNA.
DR RefSeq; XP_643915.1; XM_638823.1.
DR AlphaFoldDB; Q555Z5; -.
DR SMR; Q555Z5; -.
DR STRING; 44689.DDB0219982; -.
DR PaxDb; Q555Z5; -.
DR PRIDE; Q555Z5; -.
DR EnsemblProtists; EAL69953; EAL69953; DDB_G0274121.
DR GeneID; 8619342; -.
DR KEGG; ddi:DDB_G0274121; -.
DR dictyBase; DDB_G0274121; abcA4.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; Q555Z5; -.
DR OMA; MAIANTW; -.
DR PhylomeDB; Q555Z5; -.
DR Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR Reactome; R-DDI-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8963896; HDL assembly.
DR PRO; PR:Q555Z5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1615
FT /note="ABC transporter A family member 4"
FT /id="PRO_0000363836"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 855..875
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1022..1042
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1075..1095
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1106..1126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1135..1155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1174..1194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1218..1238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 182..383
FT /note="ABC transmembrane type-2"
FT DOMAIN 492..727
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1293..1528
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 528..535
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1331..1338
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 29
FT /note="E -> K (in Ref. 1; AAL85297)"
FT /evidence="ECO:0000305"
FT CONFLICT 38..45
FT /note="GILFGILY -> D (in Ref. 1; AAL85297)"
FT /evidence="ECO:0000305"
FT CONFLICT 66
FT /note="I -> N (in Ref. 1; AAL85297)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1615 AA; 182397 MW; 72AFF1ABFF583086 CRC64;
MESIKNQLIP LLKKNWTLKG KSKIKLLLEI LLPLISIGIL FGILYLSMII TRDFKERPAS
GFAFDIAHTK QLLIGSNGGL NSDQRNILDN LKLQVSIQHP EFSNDYINRC FVEFKDIESM
DEYFHDPFNY RGVMGGVWFP DDSFNGNTIK YSIRVDSDFT HDNTQQFQDR EDSQIYLRHY
FTQIQTGVDQ AILLTNQIAI PIFATGQRFP NPYISFWEKW TDGRKLILLN TGGVFITASL
FATLFTLITN IVIEKETKIL EGMKTMGLNS FAYYISNSII SLITLLSSTL LVSIILSASQ
LVHHVKWITL ILILIPYSIT LLLIAFILCK FFTKSKYAGL MAFLIVLLLS GIGIIIGRFN
ISPTLKLLSC LFSPIAISVA NYVWCYKDLI VFKEVDINVN MVNEYEIIGM LVFDIFLYIL
ILWYLDNVIT GEYGIPKKWY FFLTKNYWRK NKKSNINNNG VFDVEATSCN RNSSYNEKNF
EKIEHQLERP TISIRNLRKE FKTGDGNRIA VNDLSIDMYK NRIHSFLGPN GSGKSTTLSM
LTGMIEPTSG DALINGFDIR NNIDEIRKHL GVCPQSDIIW EQLTVMEHLE FYAALKGFTN
SNQRKVEATK IALEVGLGEK LNAPAGTLSG GQKRKLCLAI AFIGPNSDII LIDEPTSGLD
ASNRRLIWDF ILKYRENKTI ILVSHYLEEC DILSNTISII ANGELKCNGS SLFLKNRFGV
GYLLTISKEH NSINNSNLTK TISDIIFNHI PKGSLLSDAG TELCFRLPNE SIGNFSNLFK
ELDDRKKQLS IENYGISITT LEEVFLKIIS NSETNPNFNQ SVLNTALKTN SSGIKSYQQL
KGLLIKRVKT SRKDIKSFVL SILIPILILA GGLILYKNMR TIDIYNTVTQ PLILDFNVYG
KSVTPVSIDK VNETMTSLFD NSIGHSDRTT LVPYDELHDY LIHHYFGVPG ALYFDFRYFK
NVKFLHYNVF FNKDYLHALP IYINFVDSEI LRSVTGKRIQ TTSLPFEHIQ SPLEVASLDV
NFVAIVFFII LTLASFSLIA ASHAGNISHE RSTRVKRLLY ISGLRKSIYW LSNLIWDYLQ
TFILVIFLTI VIIAVDDKFR THFDLYISGV VLFTFSIIPL SYLMSFKFSS HGKAVGAIFA
IHFGVGLIFT VISFILRVWA IKENSISFQF LTDIIEYCFY AISPFFCFSK ILAIVTKFPG
VSRVDQSFID YWSFHFGLLP NAILFLHCIV WITWILLIDY SSEIKGKFTI SKLFSNSPIP
DSNEDSDVSN ERIIVKQLLD NNTNGGSGNV YPIIFNNLYK KFNSVGNYKS KIAVYNSTLA
IPTGQTFGLL GLNGCGKSTT LGMISGEISP TGGKIKLNGY DLIKNRNDAL TSIGYCFQFD
ALIGLLSARE QLELYCRIKG VDESKIKDTV NAFIQMMDLE SISNSNTSGY SGGNKRKVSL
SIACIGSPSI LLLDEISCGV DACVKRFMWN VLMELKKNKA IILTTHSIAE CQAVCDKLTI
MKDGKLQALG SNQHIKDKFG SGYSIEVKFK KEYLENGVEL FLQSFPSASL IDNQHALSAS
FELPNPPNNP IKLSSIFSNI EQSLKFILDD YSVSQTSIEQ IFIKLTKNSI TNIDN
