RS26_DROME
ID RS26_DROME Reviewed; 114 AA.
AC P13008; A4V0T7; C0PV38; P10380; Q0E8P4; Q9VJ88;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=40S ribosomal protein S26;
DE Short=DS31;
GN Name=RpS26; ORFNames=CG10305;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S;
RX PubMed=2911474; DOI=10.1093/nar/17.1.441;
RA Itoh N., Ohta K., Ohta M., Kawasaki T., Yamashina I.;
RT "The nucleotide sequence of cDNA for a Drosophila ribosomal protein with
RT homology to rat ribosomal protein S26.";
RL Nucleic Acids Res. 17:441-441(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION.
RC STRAIN=Canton-S;
RX PubMed=2928115; DOI=10.1093/nar/17.5.2121;
RA Itoh N., Ohta K., Ohta M., Kawasaki T., Yamashina I.;
RT "The nucleotide sequence of a gene for a putative ribosomal protein S31 of
RT Drosophila.";
RL Nucleic Acids Res. 17:2121-2121(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Sandler J., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME,
RP SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SUBUNIT: Component of the 40S small ribosomal subunit.
CC {ECO:0000269|PubMed:23636399}.
CC -!- INTERACTION:
CC P13008; Q9VBI0: Dmel\CG14543; NbExp=4; IntAct=EBI-171405, EBI-170896;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P62854}. Cytoplasm
CC {ECO:0000305|PubMed:23636399}. Rough endoplasmic reticulum
CC {ECO:0000250|UniProtKB:P49171}. Note=Detected on cytosolic polysomes
CC (By similarity). Detected in ribosomes that are associated with the
CC rough endoplasmic reticulum (By similarity).
CC {ECO:0000250|UniProtKB:P49171, ECO:0000250|UniProtKB:P62854}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS26 family.
CC {ECO:0000305}.
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DR EMBL; X13625; CAB38441.1; -; mRNA.
DR EMBL; X14247; CAA32463.1; -; Genomic_DNA.
DR EMBL; AE014134; AAN11004.1; -; Genomic_DNA.
DR EMBL; AE014134; AAN11005.1; -; Genomic_DNA.
DR EMBL; AY069761; AAL39906.1; -; mRNA.
DR EMBL; BT072894; ACN71213.1; -; mRNA.
DR PIR; S03724; R3FF26.
DR RefSeq; NP_001260537.1; NM_001273608.1.
DR RefSeq; NP_001286042.1; NM_001299113.1.
DR RefSeq; NP_523595.1; NM_078871.6.
DR RefSeq; NP_724109.1; NM_165252.2.
DR RefSeq; NP_724110.1; NM_165253.2.
DR PDB; 4V6W; EM; 6.00 A; Aa=1-114.
DR PDB; 6XU6; EM; 3.50 A; Aa=2-108.
DR PDB; 6XU7; EM; 4.90 A; Aa=2-108.
DR PDB; 6XU8; EM; 3.00 A; Aa=2-108.
DR PDBsum; 4V6W; -.
DR PDBsum; 6XU6; -.
DR PDBsum; 6XU7; -.
DR PDBsum; 6XU8; -.
DR AlphaFoldDB; P13008; -.
DR SMR; P13008; -.
DR BioGRID; 61093; 125.
DR DIP; DIP-17487N; -.
DR IntAct; P13008; 7.
DR STRING; 7227.FBpp0080641; -.
DR PaxDb; P13008; -.
DR PRIDE; P13008; -.
DR EnsemblMetazoa; FBtr0081089; FBpp0080639; FBgn0261597.
DR EnsemblMetazoa; FBtr0081090; FBpp0080640; FBgn0261597.
DR EnsemblMetazoa; FBtr0081091; FBpp0080641; FBgn0261597.
DR EnsemblMetazoa; FBtr0331455; FBpp0303872; FBgn0261597.
DR EnsemblMetazoa; FBtr0346591; FBpp0312181; FBgn0261597.
DR GeneID; 35098; -.
DR KEGG; dme:Dmel_CG10305; -.
DR CTD; 6231; -.
DR FlyBase; FBgn0261597; RpS26.
DR VEuPathDB; VectorBase:FBgn0261597; -.
DR eggNOG; KOG1768; Eukaryota.
DR GeneTree; ENSGT00390000002517; -.
DR HOGENOM; CLU_129451_0_1_1; -.
DR InParanoid; P13008; -.
DR OMA; GGRCKHN; -.
DR OrthoDB; 1591366at2759; -.
DR PhylomeDB; P13008; -.
DR Reactome; R-DME-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DME-72649; Translation initiation complex formation.
DR Reactome; R-DME-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DME-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DME-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DME-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DME-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DME-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; P13008; -.
DR BioGRID-ORCS; 35098; 2 hits in 3 CRISPR screens.
DR ChiTaRS; RpS26; fly.
DR GenomeRNAi; 35098; -.
DR PRO; PR:P13008; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0261597; Expressed in oviduct (Drosophila) and 23 other tissues.
DR ExpressionAtlas; P13008; baseline and differential.
DR Genevisible; P13008; DM.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0022626; C:cytosolic ribosome; IDA:FlyBase.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
DR GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR Gene3D; 3.30.1740.20; -; 1.
DR InterPro; IPR000892; Ribosomal_S26e.
DR InterPro; IPR038551; Ribosomal_S26e_sf.
DR PANTHER; PTHR12538; PTHR12538; 1.
DR Pfam; PF01283; Ribosomal_S26e; 1.
DR PROSITE; PS00733; RIBOSOMAL_S26E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Endoplasmic reticulum; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..114
FT /note="40S ribosomal protein S26"
FT /id="PRO_0000204520"
FT REGION 87..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 114 AA; 13267 MW; 0F0A6D8A8C6A8D7F CRC64;
MTKKRRNGGR NKHNRGHVKP VRCTNCARCV PKDKAIKKFV IRNIVEAAAV RDITEASIWD
SYVLPKLYAK LHYCVSCAIH SKVVRNRSRE ARRIRTPPLR SFPKDMARNN QNRK
