RS27L_HUMAN
ID RS27L_HUMAN Reviewed; 84 AA.
AC Q71UM5; Q9BTJ1;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=40S ribosomal protein S27-like;
DE AltName: Full=Small ribosomal subunit protein eS27-like;
GN Name=RPS27L {ECO:0000312|HGNC:HGNC:18476};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAD20974.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood {ECO:0000269|PubMed:11042152};
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2] {ECO:0000312|EMBL:AAH03667.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000312|EMBL:AAH03667.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000305};
CC -!- INTERACTION:
CC Q71UM5; Q00987: MDM2; NbExp=6; IntAct=EBI-355126, EBI-389668;
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS27 family.
CC {ECO:0000305}.
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DR EMBL; AF070668; AAD20974.1; -; mRNA.
DR EMBL; BC003667; AAH03667.1; -; mRNA.
DR CCDS; CCDS42048.1; -.
DR RefSeq; NP_057004.1; NM_015920.3.
DR AlphaFoldDB; Q71UM5; -.
DR SMR; Q71UM5; -.
DR BioGRID; 119256; 156.
DR IntAct; Q71UM5; 56.
DR MINT; Q71UM5; -.
DR STRING; 9606.ENSP00000331019; -.
DR iPTMnet; Q71UM5; -.
DR PhosphoSitePlus; Q71UM5; -.
DR SwissPalm; Q71UM5; -.
DR BioMuta; RPS27L; -.
DR DMDM; 51316258; -.
DR EPD; Q71UM5; -.
DR jPOST; Q71UM5; -.
DR MassIVE; Q71UM5; -.
DR MaxQB; Q71UM5; -.
DR PaxDb; Q71UM5; -.
DR PeptideAtlas; Q71UM5; -.
DR PRIDE; Q71UM5; -.
DR ProteomicsDB; 68634; -.
DR TopDownProteomics; Q71UM5; -.
DR Antibodypedia; 42798; 88 antibodies from 25 providers.
DR DNASU; 51065; -.
DR Ensembl; ENST00000330964.10; ENSP00000331019.5; ENSG00000185088.14.
DR GeneID; 51065; -.
DR KEGG; hsa:51065; -.
DR MANE-Select; ENST00000330964.10; ENSP00000331019.5; NM_015920.4; NP_057004.1.
DR UCSC; uc002aly.4; human.
DR CTD; 51065; -.
DR DisGeNET; 51065; -.
DR GeneCards; RPS27L; -.
DR HGNC; HGNC:18476; RPS27L.
DR HPA; ENSG00000185088; Low tissue specificity.
DR MIM; 612055; gene.
DR neXtProt; NX_Q71UM5; -.
DR OpenTargets; ENSG00000185088; -.
DR PharmGKB; PA38546; -.
DR VEuPathDB; HostDB:ENSG00000185088; -.
DR eggNOG; KOG1779; Eukaryota.
DR GeneTree; ENSGT00950000182891; -.
DR HOGENOM; CLU_130128_3_0_1; -.
DR InParanoid; Q71UM5; -.
DR OMA; LHPAIDF; -.
DR OrthoDB; 1537724at2759; -.
DR PhylomeDB; Q71UM5; -.
DR TreeFam; TF300265; -.
DR PathwayCommons; Q71UM5; -.
DR Reactome; R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-HSA-156902; Peptide chain elongation.
DR Reactome; R-HSA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-HSA-192823; Viral mRNA Translation.
DR Reactome; R-HSA-2408557; Selenocysteine synthesis.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-HSA-72649; Translation initiation complex formation.
DR Reactome; R-HSA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-HSA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-HSA-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-HSA-72764; Eukaryotic Translation Termination.
DR Reactome; R-HSA-9010553; Regulation of expression of SLITs and ROBOs.
DR Reactome; R-HSA-9633012; Response of EIF2AK4 (GCN2) to amino acid deficiency.
DR Reactome; R-HSA-9754678; SARS-CoV-2 modulates host translation machinery.
DR Reactome; R-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; Q71UM5; -.
DR SIGNOR; Q71UM5; -.
DR BioGRID-ORCS; 51065; 22 hits in 1045 CRISPR screens.
DR ChiTaRS; RPS27L; human.
DR GenomeRNAi; 51065; -.
DR Pharos; Q71UM5; Tbio.
DR PRO; PR:Q71UM5; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q71UM5; protein.
DR Bgee; ENSG00000185088; Expressed in seminal vesicle and 200 other tissues.
DR ExpressionAtlas; Q71UM5; baseline and differential.
DR Genevisible; Q71UM5; HS.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0008494; F:translation activator activity; IDA:UniProtKB.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IDA:UniProtKB.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IDA:UniProtKB.
DR GO; GO:0031571; P:mitotic G1 DNA damage checkpoint signaling; IMP:UniProtKB.
DR GO; GO:0045727; P:positive regulation of translation; IDA:UniProtKB.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 2.20.25.100; -; 1.
DR HAMAP; MF_00371; Ribosomal_S27e; 1.
DR InterPro; IPR000592; Ribosomal_S27.
DR InterPro; IPR023407; Ribosomal_S27_Zn-bd_dom_sf.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR PANTHER; PTHR11594; PTHR11594; 1.
DR Pfam; PF01667; Ribosomal_S27e; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
DR PROSITE; PS01168; RIBOSOMAL_S27E; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Zinc; Zinc-finger.
FT CHAIN 1..84
FT /note="40S ribosomal protein S27-like"
FT /id="PRO_0000149054"
FT ZN_FING 38..60
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 22
FT /note="K -> E (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 84 AA; 9477 MW; 271CCACFBB269E38 CRC64;
MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS
TVLCQPTGGK ARLTEGCSFR RKQH
