ID   RS27L_MOUSE             Reviewed;          84 AA.
AC   Q6ZWY3; Q3UB68;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=40S ribosomal protein S27-like;
GN   Name=Rps27l {ECO:0000312|MGI:MGI:1915191};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, and Pancreas;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2] {ECO:0000312|EMBL:AAH58115.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH58115.1};
RC   TISSUE=Brain {ECO:0000312|EMBL:AAH58115.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Liver, Pancreas, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS27 family.
CC       {ECO:0000305}.
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DR   EMBL; AK007689; BAB25192.1; -; mRNA.
DR   EMBL; AK011262; BAB27503.1; -; mRNA.
DR   EMBL; AK151083; BAE30096.1; -; mRNA.
DR   EMBL; BC058115; AAH58115.1; -; mRNA.
DR   CCDS; CCDS40673.1; -.
DR   RefSeq; NP_080743.1; NM_026467.4.
DR   PDB; 7LS1; EM; 3.30 A; S3=1-84.
DR   PDB; 7LS2; EM; 3.10 A; S3=1-84.
DR   PDBsum; 7LS1; -.
DR   PDBsum; 7LS2; -.
DR   AlphaFoldDB; Q6ZWY3; -.
DR   SMR; Q6ZWY3; -.
DR   BioGRID; 212553; 14.
DR   IntAct; Q6ZWY3; 3.
DR   MINT; Q6ZWY3; -.
DR   STRING; 10090.ENSMUSP00000046016; -.
DR   iPTMnet; Q6ZWY3; -.
DR   PhosphoSitePlus; Q6ZWY3; -.
DR   SwissPalm; Q6ZWY3; -.
DR   EPD; Q6ZWY3; -.
DR   jPOST; Q6ZWY3; -.
DR   MaxQB; Q6ZWY3; -.
DR   PaxDb; Q6ZWY3; -.
DR   PeptideAtlas; Q6ZWY3; -.
DR   PRIDE; Q6ZWY3; -.
DR   ProteomicsDB; 261004; -.
DR   TopDownProteomics; Q6ZWY3; -.
DR   DNASU; 67941; -.
DR   Ensembl; ENSMUST00000040917; ENSMUSP00000046016; ENSMUSG00000036781.
DR   GeneID; 67941; -.
DR   KEGG; mmu:67941; -.
DR   UCSC; uc009qfm.1; mouse.
DR   CTD; 51065; -.
DR   MGI; MGI:1915191; Rps27l.
DR   VEuPathDB; HostDB:ENSMUSG00000036781; -.
DR   eggNOG; KOG1779; Eukaryota.
DR   GeneTree; ENSGT00950000182891; -.
DR   HOGENOM; CLU_130128_3_0_1; -.
DR   InParanoid; Q6ZWY3; -.
DR   OMA; LHPAIDF; -.
DR   PhylomeDB; Q6ZWY3; -.
DR   TreeFam; TF300265; -.
DR   Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-MMU-72649; Translation initiation complex formation.
DR   Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-MMU-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-MMU-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   BioGRID-ORCS; 67941; 11 hits in 109 CRISPR screens.
DR   ChiTaRS; Rps27l; mouse.
DR   PRO; PR:Q6ZWY3; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q6ZWY3; protein.
DR   Bgee; ENSMUSG00000036781; Expressed in endocardial cushion and 269 other tissues.
DR   ExpressionAtlas; Q6ZWY3; baseline and differential.
DR   Genevisible; Q6ZWY3; MM.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; ISO:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0008494; F:translation activator activity; ISO:MGI.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
DR   GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; ISO:MGI.
DR   GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISO:MGI.
DR   GO; GO:0031571; P:mitotic G1 DNA damage checkpoint signaling; ISO:MGI.
DR   GO; GO:0045727; P:positive regulation of translation; ISO:MGI.
DR   GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 2.20.25.100; -; 1.
DR   HAMAP; MF_00371; Ribosomal_S27e; 1.
DR   InterPro; IPR000592; Ribosomal_S27.
DR   InterPro; IPR023407; Ribosomal_S27_Zn-bd_dom_sf.
DR   InterPro; IPR011332; Ribosomal_zn-bd.
DR   PANTHER; PTHR11594; PTHR11594; 1.
DR   Pfam; PF01667; Ribosomal_S27e; 1.
DR   SUPFAM; SSF57829; SSF57829; 1.
DR   PROSITE; PS01168; RIBOSOMAL_S27E; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Metal-binding; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; Zinc; Zinc-finger.
FT   CHAIN           1..84
FT                   /note="40S ribosomal protein S27-like"
FT                   /id="PRO_0000149055"
FT   ZN_FING         38..60
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   84 AA;  9477 MW;  271CCACFBB269E38 CRC64;
     MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS
     TVLCQPTGGK ARLTEGCSFR RKQH