RS27L_RAT
ID RS27L_RAT Reviewed; 84 AA.
AC P24051;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=40S ribosomal protein S27-like;
GN Name=Rps27l;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-34.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=8441676; DOI=10.1093/nar/21.3.649;
RA Chan Y.-L., Suzuki K., Olvera J., Wool I.G.;
RT "Zinc finger-like motifs in rat ribosomal proteins S27 and S29.";
RL Nucleic Acids Res. 21:649-655(1993).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=10820185; DOI=10.1046/j.1471-4159.2000.0742259.x;
RA Thomas E.A., Alvarez C.E., Sutcliffe J.G.;
RT "Evolutionarily distinct classes of S27 ribosomal proteins with
RT differential mRNA expression in rat hypothalamus.";
RL J. Neurochem. 74:2259-2267(2000).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000305};
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the striatum,
CC hypothalamus, heart and liver and at lower levels in the cerebellum,
CC hippocampus and pons. {ECO:0000269|PubMed:10820185}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS27 family.
CC {ECO:0000305}.
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DR EMBL; X59375; CAA42019.1; -; mRNA.
DR PIR; S30297; R3RT27.
DR RefSeq; NP_001263406.1; NM_001276477.1.
DR AlphaFoldDB; P24051; -.
DR SMR; P24051; -.
DR BioGRID; 596358; 1.
DR IntAct; P24051; 1.
DR STRING; 10116.ENSRNOP00000067129; -.
DR iPTMnet; P24051; -.
DR PhosphoSitePlus; P24051; -.
DR jPOST; P24051; -.
DR PaxDb; P24051; -.
DR PeptideAtlas; P24051; -.
DR PRIDE; P24051; -.
DR Ensembl; ENSRNOT00000090977; ENSRNOP00000071243; ENSRNOG00000050473.
DR GeneID; 681429; -.
DR KEGG; rno:681429; -.
DR CTD; 51065; -.
DR RGD; 1595396; Rps27l.
DR VEuPathDB; HostDB:ENSRNOG00000066445; -.
DR eggNOG; KOG1779; Eukaryota.
DR GeneTree; ENSGT00950000182891; -.
DR InParanoid; P24051; -.
DR OMA; LHPAIDF; -.
DR OrthoDB; 1537724at2759; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P24051; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000050473; Expressed in pancreas and 20 other tissues.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; ISO:RGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0008494; F:translation activator activity; ISO:RGD.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:RGD.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; ISO:RGD.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISO:RGD.
DR GO; GO:0031571; P:mitotic G1 DNA damage checkpoint signaling; ISO:RGD.
DR GO; GO:0045727; P:positive regulation of translation; ISO:RGD.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 2.20.25.100; -; 1.
DR HAMAP; MF_00371; Ribosomal_S27e; 1.
DR InterPro; IPR000592; Ribosomal_S27.
DR InterPro; IPR023407; Ribosomal_S27_Zn-bd_dom_sf.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR PANTHER; PTHR11594; PTHR11594; 1.
DR Pfam; PF01667; Ribosomal_S27e; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
DR PROSITE; PS01168; RIBOSOMAL_S27E; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Metal-binding; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8441676"
FT CHAIN 2..84
FT /note="40S ribosomal protein S27-like"
FT /id="PRO_0000149056"
FT ZN_FING 37..59
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 84 AA; 9477 MW; 271CCACFBB269E38 CRC64;
MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS
TVLCQPTGGK ARLTEGCSFR RKQH
