RS27_RAT
ID RS27_RAT Reviewed; 84 AA.
AC Q71TY3;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=40S ribosomal protein S27;
GN Name=Rps27 {ECO:0000312|RGD:621045};
GN Synonyms=S27-1 {ECO:0000312|EMBL:AAD56582.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD56582.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAD56582.1};
RC TISSUE=CNS {ECO:0000312|EMBL:AAD56582.1}, and Corpus striatum;
RX PubMed=10820185; DOI=10.1046/j.1471-4159.2000.0742259.x;
RA Thomas E.A., Alvarez C.E., Sutcliffe J.G.;
RT "Evolutionarily distinct classes of S27 ribosomal proteins with
RT differential mRNA expression in rat hypothalamus.";
RL J. Neurochem. 74:2259-2267(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Component of the small ribosomal subunit (By similarity).
CC Required for proper rRNA processing and maturation of 18S rRNAs (By
CC similarity). {ECO:0000250|UniProtKB:P42677}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000305};
CC -!- SUBUNIT: Component of the small ribosomal subunit.
CC {ECO:0000250|UniProtKB:P42677}.
CC -!- TISSUE SPECIFICITY: Expressed in the striatum, cerebellum, hippocampus,
CC hypothalamus, pons, heart and liver. {ECO:0000269|PubMed:10820185}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS27 family.
CC {ECO:0000305}.
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DR EMBL; AF184893; AAD56582.1; -; mRNA.
DR EMBL; BC061539; AAH61539.1; -; mRNA.
DR RefSeq; NP_446049.1; NM_053597.3.
DR AlphaFoldDB; Q71TY3; -.
DR SMR; Q71TY3; -.
DR BioGRID; 250185; 4.
DR IntAct; Q71TY3; 3.
DR STRING; 10116.ENSRNOP00000022897; -.
DR iPTMnet; Q71TY3; -.
DR PhosphoSitePlus; Q71TY3; -.
DR jPOST; Q71TY3; -.
DR PaxDb; Q71TY3; -.
DR PRIDE; Q71TY3; -.
DR Ensembl; ENSRNOT00000022897; ENSRNOP00000022897; ENSRNOG00000016961.
DR GeneID; 94266; -.
DR KEGG; rno:94266; -.
DR UCSC; RGD:621045; rat.
DR CTD; 6232; -.
DR RGD; 621045; Rps27.
DR eggNOG; KOG1779; Eukaryota.
DR GeneTree; ENSGT00950000182891; -.
DR HOGENOM; CLU_130128_3_0_1; -.
DR InParanoid; Q71TY3; -.
DR OMA; VYSHANT; -.
DR OrthoDB; 1537724at2759; -.
DR PhylomeDB; Q71TY3; -.
DR TreeFam; TF300265; -.
DR Reactome; R-RNO-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-2467813; Separation of Sister Chromatids.
DR Reactome; R-RNO-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-RNO-5663220; RHO GTPases Activate Formins.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-68877; Mitotic Prometaphase.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-9648025; EML4 and NUDC in mitotic spindle formation.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q71TY3; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000016961; Expressed in thymus and 19 other tissues.
DR Genevisible; Q71TY3; RN.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0014069; C:postsynaptic density; ISO:RGD.
DR GO; GO:0098793; C:presynapse; IDA:SynGO.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 2.20.25.100; -; 1.
DR HAMAP; MF_00371; Ribosomal_S27e; 1.
DR InterPro; IPR000592; Ribosomal_S27.
DR InterPro; IPR023407; Ribosomal_S27_Zn-bd_dom_sf.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR PANTHER; PTHR11594; PTHR11594; 1.
DR Pfam; PF01667; Ribosomal_S27e; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
DR PROSITE; PS01168; RIBOSOMAL_S27E; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Zinc; Zinc-finger.
FT CHAIN 1..84
FT /note="40S ribosomal protein S27"
FT /id="PRO_0000149053"
FT ZN_FING 38..60
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 84 AA; 9461 MW; 242C4466AC8A8900 CRC64;
MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS
TVLCQPTGGK ARLTEGCSFR RKQH
