BACH_HALHM
ID BACH_HALHM Reviewed; 206 AA.
AC P33970;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Halorhodopsin;
DE Short=HR;
DE Flags: Fragment;
GN Name=hop;
OS Halobacterium halobium (strain mex).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=33003;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1420272; DOI=10.1016/0005-2736(92)90246-i;
RA Otomo J., Tomioka H., Sasabe H.;
RT "Properties and the primary structure of a new halorhodopsin from
RT halobacterial strain mex.";
RL Biochim. Biophys. Acta 1112:7-13(1992).
CC -!- FUNCTION: Light-driven chloride pump.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the archaeal/bacterial/fungal opsin family.
CC {ECO:0000305}.
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DR EMBL; D11136; BAA01910.1; -; Genomic_DNA.
DR AlphaFoldDB; P33970; -.
DR SMR; P33970; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR InterPro; IPR001425; Arc/bac/fun_rhodopsins.
DR InterPro; IPR018229; Rhodopsin_retinal_BS.
DR PANTHER; PTHR28286; PTHR28286; 1.
DR Pfam; PF01036; Bac_rhodopsin; 1.
DR PRINTS; PR00251; BACTRLOPSIN.
DR SMART; SM01021; Bac_rhodopsin; 1.
DR PROSITE; PS00950; BACTERIAL_OPSIN_1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chloride; Chromophore; Ion transport; Membrane;
KW Photoreceptor protein; Receptor; Retinal protein; Sensory transduction;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN <1..>206
FT /note="Halorhodopsin"
FT /id="PRO_0000196266"
FT TRANSMEM <1..15
FT /note="Helical; Name=Helix A"
FT /evidence="ECO:0000250"
FT TOPO_DOM 16..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 22..45
FT /note="Helical; Name=Helix B"
FT /evidence="ECO:0000250"
FT TOPO_DOM 46..75
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 76..97
FT /note="Helical; Name=Helix C"
FT /evidence="ECO:0000250"
FT TOPO_DOM 98..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 101..124
FT /note="Helical; Name=Helix D"
FT /evidence="ECO:0000250"
FT TOPO_DOM 125..127
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 128..150
FT /note="Helical; Name=Helix E"
FT /evidence="ECO:0000250"
FT TOPO_DOM 151..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 163..186
FT /note="Helical; Name=Helix F"
FT /evidence="ECO:0000250"
FT TOPO_DOM 187..195
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 196..>206
FT /note="Helical; Name=Helix G"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 206
SQ SEQUENCE 206 AA; 21871 MW; 2D31077154982BA0 CRC64;
IALAGLSILL FVYMGRNVED PRAQLIFVAT LMVPLVSISS YTGLVSGLTV GFLEMPAGHA
LAGMGAGPEG GVFTPWGRYL TWAFSTPMIL IALGLLAGSN MSKLFTAVVA DVGMCITGLA
AALTTSSYLL RWVWYGISCA FFVVVLYILL AEWAKDAEVA GTADIFNTLK VLTVVLWLGY
PIFWALGAEG LAVLDIAITS WAYSGM
