BACH_HALMA
ID BACH_HALMA Reviewed; 276 AA.
AC Q5V1N0;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Halorhodopsin;
DE Short=HmHR;
DE Flags: Precursor;
GN Name=hop; OrderedLocusNames=rrnAC1659;
OS Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS B-1809) (Halobacterium marismortui).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=272569;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX PubMed=15520287; DOI=10.1101/gr.2700304;
RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA Hood L., Ng W.V.;
RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT Dead Sea.";
RL Genome Res. 14:2221-2234(2004).
RN [2]
RP FUNCTION, INDUCTION, CHARACTERIZATION, AND BIOPHYSICOCHEMICAL PROPERTIES.
RX PubMed=20802037; DOI=10.1128/jb.00642-10;
RA Fu H.Y., Lin Y.C., Chang Y.N., Tseng H., Huang C.C., Liu K.C., Huang C.S.,
RA Su C.W., Weng R.R., Lee Y.Y., Ng W.V., Yang C.S.;
RT "A novel six-rhodopsin system in a single archaeon.";
RL J. Bacteriol. 192:5866-5873(2010).
CC -!- FUNCTION: Light-driven chloride pump. {ECO:0000269|PubMed:20802037}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=576 nm {ECO:0000269|PubMed:20802037};
CC Note=If the chloride concentration decreases, the spectrum exhibits a
CC red-shift.;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Expressed constitutively throughout the growth phases, both
CC in presence and absence of white light. {ECO:0000269|PubMed:20802037}.
CC -!- PTM: The covalent binding of retinal to the apoprotein, bacterioopsin,
CC generates bacteriorhodopsin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal/bacterial/fungal opsin family.
CC {ECO:0000305}.
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DR EMBL; AY596297; AAV46572.1; -; Genomic_DNA.
DR RefSeq; WP_011223771.1; NZ_CP039138.1.
DR AlphaFoldDB; Q5V1N0; -.
DR SMR; Q5V1N0; -.
DR STRING; 272569.rrnAC1659; -.
DR EnsemblBacteria; AAV46572; AAV46572; rrnAC1659.
DR GeneID; 40152624; -.
DR KEGG; hma:rrnAC1659; -.
DR PATRIC; fig|272569.17.peg.2347; -.
DR eggNOG; arCOG02811; Archaea.
DR HOGENOM; CLU_054785_5_1_2; -.
DR OMA; VCRQVFW; -.
DR Proteomes; UP000001169; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR InterPro; IPR001425; Arc/bac/fun_rhodopsins.
DR InterPro; IPR018229; Rhodopsin_retinal_BS.
DR PANTHER; PTHR28286; PTHR28286; 1.
DR Pfam; PF01036; Bac_rhodopsin; 1.
DR PRINTS; PR00251; BACTRLOPSIN.
DR SMART; SM01021; Bac_rhodopsin; 1.
DR PROSITE; PS00950; BACTERIAL_OPSIN_1; 1.
DR PROSITE; PS00327; BACTERIAL_OPSIN_RET; 1.
PE 1: Evidence at protein level;
KW Chromophore; Ion transport; Membrane; Photoreceptor protein;
KW Pyrrolidone carboxylic acid; Receptor; Reference proteome; Retinal protein;
KW Sensory transduction; Transmembrane; Transmembrane helix; Transport.
FT PROPEP 1..20
FT /evidence="ECO:0000250"
FT /id="PRO_0000428851"
FT CHAIN 21..276
FT /note="Halorhodopsin"
FT /id="PRO_0000428852"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 21
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 241
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 276 AA; 29043 MW; A6817F3BFBDF50E5 CRC64;
MTAASTTATT VLQATQSDVL QEIQSNFLLN SSIWVNIALA GVVILLFVAM GRDLESPRAK
LIWVATMLVP LVSISSYAGL ASGLTVGFLQ MPPGHALAGQ EVLSPWGRYL TWTFSTPMIL
LALGLLADTD IASLFTAITM DIGMCVTGLA AALITSSHLL RWVFYGISCA FFVAVLYVLL
VQWPADAEAA GTSEIFGTLK ILTVVLWLGY PILWALGSEG VALLSVGVTS WGYSGLDILA
KYVFAFLLLR WVAANEGTVS GSGMGIGSGG ATPADD
